DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and hsp-6

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001370558.1	Gene:	hsp-6 / 178873	WormBaseID:	WBGene00002010	Length:	657	Species:	Caenorhabditis elegans

Alignment Length:	684	Identity:	170/684 - (24%)
Similarity:	297/684 - (43%)	Gaps:	117/684 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SALLAGIALSQ--GAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAF-RDGTRTIG 69
            |:|::..:||.  ...|:.:|||:....|.::....| ::..|.|..|.||:.:|| .||.|.:|
Worm    17 SSLMSARSLSDKPKGHVIGIDLGTTNSCVSIMEGKTP-KVIENAEGVRTTPSTVAFTADGERLVG 80

  Fly    70 EDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDEFSVE 134
            ..|:...:.:..:.......|:|:..::|.|....|..||..:...   |...:.::....:|..
Worm    81 APAKRQAVTNSANTLFATKRLIGRRYEDPEVQKDLKVVPYKIVKAS---NGDAWVEAQGKVYSPS 142

  Fly   135 ELVAQLLVKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALN 199
            ::.|.:|:|.|:.|:..:...:...|:|||.||..::|:|...|.|::.|.||::||:..|.||.
Worm   143 QVGAFVLMKMKETAESYLGTTVNNAVVTVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALA 207

  Fly   200 YGVFHRGEINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQ 264
            ||:    :.:...:....||:|......:::..|          ..|.:|.....|..|||.:..
Worm   208 YGL----DKDAGDKIIAVYDLGGGTFDVSILEIQ----------KGVFEVKSTNGDTFLGGEDFD 258

  Fly   265 LRLRDYLAQEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDID----F 325
            ..|..:|..||.  |:...|:|..|:|:.:|.:.|.:.|..||:.|:....:..:..|..    .
Worm   259 HALVHHLVGEFK--KEQGVDLTKDPQAMQRLREAAEKAKCELSSTTQTDINLPYITMDQSGPKHL 321

  Fly   326 KLPVTREKLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQEL 390
            .|.:||.|.||:..||..|..:|..:||..:.:....|..|:|.||.:|:|:||.|::.:..:..
Worm   322 NLKLTRAKFEQIVGDLIKRTIEPCRKALHDAEVKSSQIADVLLVGGMSRMPKVQATVQEIFGKVP 386

  Fly   391 GKNLNADESATMGAVYKAA---------------DLSAGFK-----VKKFVVKDATLFPLQVSFE 435
            .|.:|.||:..|||..:.|               .||.|.:     :.|.:.::.|:...:....
Worm   387 SKAVNPDEAVAMGAAIQGAVLAGDVTDVLLLDVTPLSLGIETLGGIMTKLITRNTTIPTKKSQVF 451

  Fly   436 RDPGDGAAVKQVK-----RAL---------FALMN--PYPQ---KKVITFNKHTDDFEFYVNYAD 481
            ....||....|:|     |.:         |:|:.  |.|:   :..:||:   .|....||.:.
Worm   452 STAADGQTQVQIKVFQGEREMATSNKLLGQFSLVGIPPAPRGVPQVEVTFD---IDANGIVNVSA 513

  Fly   482 LDRYS--KEEIAALGSLNVTKVQLKQVKELLEKS------KKELVD--NKGIKAYFYLDDSGIFR 536
            .||.:  :::|....|..::|.|::.:.:..||:      :||||:  |:.         .||..
Worm   514 RDRGTGKEQQIVIQSSGGLSKDQIENMIKEAEKNAAEDAKRKELVEVINQA---------EGIIH 569

  Fly   537 CTGVEYV-YEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKK--DNSEQE------EAANAGEE 592
            .|..:.. :..|.|:|:.:             .|.||..:.||  ||.:.|      ||.|..::
Worm   570 DTEAKMTEFADQLPKDECE-------------ALRTKIADTKKILDNKDNETPEAIKEACNTLQQ 621

  Fly   593 PS-----KSEDNEKAKEE--DASKEQKSEESTKQ 619
            .|     .:..|..||..  ||.:.:.:||..|:
Worm   622 QSLKLFEAAYKNMAAKNSGGDAQEAKTAEEPKKE 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	166/668 (25%)
		HYOU1-like_NBD	23..409	CDD:212672	106/390 (27%)
		TAF4	<572..>627	CDD:296797	18/63 (29%)
hsp-6	NP_001370558.1	dnaK	30..646	CDD:234715	163/660 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900