DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and hsp-110

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_498868.1	Gene:	hsp-110 / 176195	WormBaseID:	WBGene00016250	Length:	776	Species:	Caenorhabditis elegans

Alignment Length:	897	Identity:	209/897 - (23%)
Similarity:	389/897 - (43%)	Gaps:	156/897 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIG---EDAQTIGIKDPNS 82
            :|:..|:|:....:||...| .:|:..|..|...|||.::|....|::|   ..|.|..||  |:
Worm     2 SVLGFDIGNLNCYIGVARQG-GIEVITNDYSLHATPACVSFGPKDRSMGVAARQAVTTNIK--NT 63

  Fly    83 AYGYLLDLLGKTIDNPIVDLYRKRFP-------------YYNIVGDPERNTVVFRKSDTDEFSVE 134
            ...: ..|:|:...:|:...:....|             ..:.:|:|.            .|:.|
Worm    64 VINF-KHLIGRKFSDPVAQRFIPFIPCKVVKLPNDDIGVQVSYLGEPH------------TFTPE 115

  Fly   135 ELVAQLLVKAKQFAQESVQ--QPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVA 197
            :::|.||.|.:...:..:.  :.:::|||.||.||...:|.|:|||.|.|.|..|:::|:..|:|
Worm   116 QVLAALLTKLRTIVESQLSDVKKVSDCVLAVPSYFTDVQRRAVLSAIQYAGLNSLRIVNETTAIA 180

  Fly   198 LNYGVFHRG--EINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGG 260
            |.||::.:.  |.:..::..:|.|:|...|.|::|::...|          :|::...||...||
Worm   181 LAYGIYKQDLPEEDAKSRNVVFLDIGHSSTQASLVAFNRGK----------LQMVNTSYDLESGG 235

  Fly   261 LEIQLRLRDYLAQEFNALKKTK--TDVTTSPRALAKLFKEAGRLKNVLSAN-TEFFAQIENLIED 322
            :.....:|::..:||    |||  .|..||||...:|..|..|:|..:||| |.....||..:||
Worm   236 IWFDALIREHFRKEF----KTKYGIDAATSPRPWLRLLDECERVKKQMSANQTPIPLNIECFMED 296

  Fly   323 IDFKLPVTREKLEQLCEDLWPRATKPLEEALASS-HLSLDVINQVILFGGGTRVPRVQETIKAVI 386
            .|....:.|::.|.|...::.|..:.|....|.. .:..:.|:::.:.||.:|:|.::|.:|.:.
Worm   297 KDVTGKMQRQEFEDLAAPIFNRIKQVLINLFADGVSIKPEEIDEIEIVGGSSRIPMIREIVKDLF 361

  Fly   387 KQELGKNLNADESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRAL 451
            .:|....:|.||:...||..:.|.||..|:|::|.:||...:.:::|:.....:|.     :..:
Worm   362 GKEPKTTMNQDEAVARGAAMQCAILSPTFRVREFAIKDTQPYRIRLSWNSTGENGG-----ENDV 421

  Fly   452 FALMNPYPQKKVITFNKHTDDFEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKE 516
            |:..:..|..|:::..: :..|....:||..:.....:: .:||..|             ...:.
Worm   422 FSPRDEVPFSKLVSLLR-SGPFNVEAHYAQPNVVPHNQV-HIGSWKV-------------NGARP 471

  Fly   517 LVD--NKGIKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKD 579
            ..|  |:.:|....::..|||...... :||.:..|:...|...:                   |
Worm   472 GADGGNQKVKVKVRVNPDGIFTIASAT-MYEPRIVEEVPAEAMEV-------------------D 516

  Fly   580 NSEQEEAANAGEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKS-PVTYESQT 643
            ...:.||.....||.|                          :.|...:.|..::| ||:|:.|.
Worm   517 GDAKTEAPAEPLEPVK--------------------------KTKLVPVDLEVIESIPVSYDVQK 555

  Fly   644 QFVVPLVGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEK 708
            ...:.|   ...:|.|:..|  ||:        |.|:||.::.|::.|:.:: ||:..|....::
Worm   556 FHNLEL---QMQESDAREKA--KAD--------AKNSLEEYVYEMRDKVSDQ-YAEFITPAAADE 606

  Fly   709 LLAECSTLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAEKF 773
            ..:..::..:|||::.||.:.::||::|::||.:....:.|:.|.|.|       |...|..::.
Worm   607 FRSVLTSTEDWLYDEGEDAERDVYEKRLSELKAVGTPVVERYRESETR-------KPAFDSFDQS 664

  Fly   774 LVTGRNLTKDTNPEKDVFTQVEIDTLDKVIT---ETNAWLKTETAAQKKLAKNADIRLTVKDITD 835
            ::..|...:|.......:..::...::|||.   :...||......|:..:|.....:..::|..
Worm   665 IMRVRKAYEDYANGGPTYAHLDSKEMEKVINAIEDKKKWLDEARHKQETRSKTDAPVVFTEEILQ 729

  Fly   836 KMSLLDREVKYLVNKIKIWKPKVKPAAEKEKKKEEEVVASGSGDDTKSEDAE 887
            ..::.:..|..::|       |.||||....||||...|  :||..:|:..|
Worm   730 NKNVFENVVNPILN-------KKKPAAPAPPKKEEPQPA--AGDQPQSQPGE 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	145/628 (23%)
		HYOU1-like_NBD	23..409	CDD:212672	109/409 (27%)
		TAF4	<572..>627	CDD:296797	7/54 (13%)
hsp-110	NP_498868.1	HSPA4_like_NDB	2..387	CDD:212670	111/414 (27%)
hsp-110	NP_498868.1	HSP70	3..650	CDD:278441	178/756 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810