DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and hsp-4

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001370395.1	Gene:	hsp-4 / 174203	WormBaseID:	WBGene00002008	Length:	657	Species:	Caenorhabditis elegans

Alignment Length:	731	Identity:	185/731 - (25%)
Similarity:	312/731 - (42%)	Gaps:	124/731 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLLSALLAGIALSQGAA---------VMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILA 60
            |:|.|.:|.....:||:         ::.:|||:.:..|||...| .:||..|.:..|.||:.:|
Worm     6 LILIAFVANAYCDEGASTEKEEKMGTIIGIDLGTTYSCVGVFKNG-RVEIIANDQGNRITPSYVA 69

  Fly    61 FR--DGTRTIGEDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVF 123
            |.  .|.|.||:.|:.....:|.:.......|:|:..:...|....|.:|:..:....:.|..|.
Worm    70 FSGDQGERLIGDAAKNQLTINPENTIFDAKRLIGRFYNEKTVQQDIKHWPFKIVDKSNKPNVEVK 134

  Fly   124 RKSDTDEFSVEELVAQLLVKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQ 188
            ..|:|.:|:.||:.|.:|.|.||.|:..:...:...|:|||.||..|:::|...|..:|.|.|::
Worm   135 VGSETKQFTPEEVSAMVLTKMKQIAESYLGHEVKNAVVTVPAYFNDAQKQATKDAGSIAGLNVVR 199

  Fly   189 LINDYAAVALNYGVFHR-GEINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGV 252
            :||:..|.|:.||:..: ||.|     .|.:|:|......::::..          :.|.:||..
Worm   200 IINEPTAAAIAYGLDKKDGERN-----ILVFDLGGGTFDVSLLTID----------SGVFEVLAT 249

  Fly   253 GYDRTLGGLEIQLRLRDYLAQEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIE 317
            ..|..|||.:...|:.:|..:.:.  ||:..|:....||:.||.:|..:.|..||...:...:||
Worm   250 NGDTHLGGEDFDQRVMEYFIKLYK--KKSGKDLRKDNRAVQKLRREVEKAKRALSTQHQTKIEIE 312

  Fly   318 NLIEDIDFKLPVTREKLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETI 382
            :|.:..||...:||.|.|:|..||:....||:::.|..:.:....:::::|.||.||:|:||:.|
Worm   313 SLFDGEDFSETLTRAKFEELNMDLFRATLKPVQKVLEDADMKKTDVHEIVLVGGSTRIPKVQQLI 377

  Fly   383 KAVIK-QELGKNLNADESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQ 446
            |.... :|..:.:|.||:...||..:|..:.........|:.|..  ||.:..|       .|..
Worm   378 KDYFNGKEPSRGINPDEAVAYGAAVQAGVIGGVENTGDVVLLDVN--PLTLGIE-------TVGG 433

  Fly   447 VKRALFALMNPYPQKKVITFNKHTDDFEFYVNYADLDRYSKE-----EIAALGSLNVTKVQ---- 502
            |...|.......|.||...|:...|.    .:...:..|..|     :...||:.:||.:.
Worm   434 VMTKLIGRNTVIPTKKSQVFSTAADS----QSAVSIVIYEGERPMVMDNHKLGNFDVTGIPPAPR 494

  Fly   503 -LKQVKELLEKSKKELVDNKGIKAYFYLDDSGIFRCTG------VEYVYEKQKPED------DAD 554
             :.|::...|      :|..|| .:...:|.|    ||      :...:.:..|||      |||
Worm   495 GVPQIEVTFE------IDVNGI-LHVSAEDKG----TGNKNKLTITNDHNRLSPEDIERMINDAD 548

  Fly   555 EDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEPSKSEDNEKAKEEDASKEQKSEESTKQ 619
                  ||.:      ..:.:::|..|..|..|.|          .:.|.:.|.||:...:.|.:
Worm   549 ------KFAA------DDQAQKEKVESRNELEAYA----------YQMKTQIADKEKLGGKLTDE 591

  Fly   620 DTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAH 684
            |               .|:.||..:..:..:||..|.|..:    ||  ||:..|||....:.:.
Worm   592 D---------------KVSIESAVERAIEWLGSNQDASTEE----NK--EQKKELESVVQPIVSK 635

  Fly   685 IIEV----QQKLDEES 696
            :...    :|..:|.|
Worm   636 LYSAGGQGEQASEEPS 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	162/628 (26%)
		HYOU1-like_NBD	23..409	CDD:212672	114/389 (29%)
		TAF4	<572..>627	CDD:296797	11/54 (20%)
hsp-4	NP_001370395.1	PTZ00009	33..643	CDD:240227	176/694 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810