DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and T24H7.2

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_495249.1	Gene:	T24H7.2 / 174033	WormBaseID:	WBGene00020781	Length:	925	Species:	Caenorhabditis elegans

Alignment Length:	958	Identity:	341/958 - (35%)
Similarity:	523/958 - (54%)	Gaps:	85/958 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LVLLLSALLAGIALSQG-AAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTR 66
            ||:||..|   .|.|.| .|.|::|||::::|:|:|.||:||:||||.||:||||.::..:||.|
Worm     9 LVILLGCL---FATSDGQLAAMTIDLGTQFLKIGIVKPGIPMDIALNTESRRKTPNVVMIQDGHR 70

  Fly    67 TIGEDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDEF 131
            |..:.|..:.::.|:..:|.|.||:||:..:|..:|:::|..::.:...|:..:.:..|...:.:
Worm    71 TFADAAIGMQVRYPHLVHGQLNDLVGKSTQHPSFELFKRRNTFFEVDDAPKNASSINFKLGGESY 135

  Fly   132 SVEELVAQLLVKAKQFAQESVQ-QPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAA 195
            :||.|.|.:|..||:|.:|..| ..|.:.|:|||.||..|||.|:..|||:|.|.|||||||..|
Worm   136 TVEALTAMILANAKKFTEEYAQAAEIKDVVITVPVYFTPAERLAVERAAQMAGLTVLQLINDGTA 200

  Fly   196 VALNYGVFHRGEINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGG 260
            .||::|:|.|.||.|..|..:.|||||.||:|.:|.::|||:|..::  |.:.|||||:||||||
Worm   201 AALSHGIFRRKEIGEKPQRLMVYDMGAAKTTATIVEFKLVKEKYEKQ--PKMTVLGVGFDRTLGG 263

  Fly   261 LEIQLRLRDYLAQEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDF 325
            :|:..||||:|.:.|....|.||.|.|:.||:.|..|||.|||.|||||.|.|||||:..||||.
Worm   264 IEMTNRLRDHLIEMFEKNYKPKTKVNTNRRAMTKFSKEAERLKQVLSANAEHFAQIESAHEDIDA 328

  Fly   326 KLPVTREKLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETI-KAVIKQE 389
            ||.||||....|..|:..|..:|:|:||..:.:.:|.|:|.:|.|.|||||:|||.: |.:..:|
Worm   329 KLKVTREDFNHLISDMESRFGEPIEQALRMAQIPIDDIDQFVLMGAGTRVPKVQEIVQKTIGTKE 393

  Fly   390 LGKNLNADESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSF---------ERDPGDGAAVK 445
            :||.||.||:..|||:::||.||.|||||.|.:::..:||::|.|         |...|:    |
Worm   394 IGKFLNTDEAVAMGALFQAAHLSKGFKVKPFNIEEKVIFPVEVHFVSKIRDEKTEEITGE----K 454

  Fly   446 QVKRALFALMNPYP-QKKVITFNKHTDDFEFYVNYADLDRYSKEEIAALGSL--NVTKVQLKQVK 507
            .|.:.|||..:.|| ..|.|:...::|||...:.|..::.::|:::..:|||  |:..|::..:.
Worm   455 NVVKTLFAANSVYPTHPKTISLTSYSDDFSVALKYGKIESFTKQQVQEIGSLLDNLVDVEISGLS 519

  Fly   508 ELLEKSKKELVDNKGIKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLF-- 570
            |.|:....|..:.||:|..|.:|.|||.|....|.::|        .:...:....||:|.||
Worm   520 EALKNRSSEESEFKGVKVSFIVDASGIVRVRRAEALFE--------PKSGLVGSIASTISGLFSS 576

  Fly   571 -TKEGEEKKDNSEQEEAANAGEEPSKSEDNEKAKEEDASKEQKSE---ESTKQDTEAKNETIKLV 631
             |:|||...|:|..:..    ||  |:|:.|..|.||::.|.:.|   .||.:::...|||.|..
Worm   577 KTEEGEPTTDDSTPQST----EE--KTEEKESVKVEDSTPEPEPETPVNSTSEESPKTNETEKNA 635

  Fly   632 T-------------VKSPVTYESQTQFVVPLVGSAYDQSVAKLAAINKAEEQRVRLESAF--NAL 681
            :             :.|.|......::....|.:.||....|......||::|:..|.|.  |.|
Worm   636 SSGNATEVKEKKKELPSIVRLRITNKYPSAFVPNKYDVQEEKRRMEAFAEKERLASERAAVENEL 700

  Fly   682 EAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYEDL-EDPKAEIYEEKLAQLKKLSNV 745
            |:...|..|.|:|..:......|||.||......:..||.:|: :|...:.:.:.|.:||.:...
Worm   701 ESFNFECSQYLEETEFTDYMADEEKTKLEDSVKRIRAWLEDDVTKDTPTKDFTDNLLELKNVVRS 765

  Fly   746 FLARHWEHEER-PEAIKALKGMIDGAEKFLVTGRNLTKDTNPEKDVFTQVEIDTLDKVITETNAW 809
            ...|. ||::. ||.:|:|:.:::........|.|:    :.||.:|.:.:.|.|...:.:...|
Worm   766 VKKRQ-EHDKAVPEKLKSLETLLETTFSLTTLGNNV----DEEKALFKKEDRDGLKSKLDKLKIW 825

  Fly   810 LKTETAAQKKL---AKNADIRLTVKDITDKMSLLDREVKYLVNKIKIWKPKVKPAAEKEKKKEEE 871
            :   |..:|.|   .|..|...|.|||..|...|:|||...:.|:|    |:....:..|..:.:
Worm   826 V---TDVRKHLDLKKKTDDFNFTGKDIDTKTKNLNREVDRFMKKMK----KITTLDDLAKDGKID 883

  Fly   872 VVASGSGDDTKSEDAEQQQ-EQATKEEQQEQEPVDEITPTPAEEETKT 918
            :       ||..|:||::: ||..|:|::..:..:| :....|.|.||
Worm   884 I-------DTIVEEAEKKKAEQDKKKEKKSTKKANE-SKVENESEIKT 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	251/622 (40%)
		HYOU1-like_NBD	23..409	CDD:212672	179/387 (46%)
		TAF4	<572..>627	CDD:296797	18/57 (32%)
T24H7.2	NP_495249.1	HYOU1-like_NBD	27..413	CDD:212672	179/387 (46%)
T24H7.2	NP_495249.1	DnaK	29..669	CDD:223520	257/659 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	432	1.000	Domainoid score	I293
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4658
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2181
OMA	1	1.010	-	-		QHG54551
OrthoDB	1	1.010	-	-		D125779at33208
OrthoFinder	1	1.000	-	-		FOG0003505
OrthoInspector	1	1.000	-	-		otm14519
orthoMCL	1	0.900	-	-		OOG6_101811
Panther	1	1.100	-	-	O	PTHR45639
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3997
SonicParanoid	1	1.000	-	-		X2877
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810