DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and Hspa4

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_032326.3	Gene:	Hspa4 / 15525	MGIID:	1342292	Length:	842	Species:	Mus musculus

Alignment Length:	927	Identity:	250/927 - (26%)
Similarity:	429/927 - (46%)	Gaps:	111/927 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYG 85
            :|:.:|||.:...|.|...| .:|...|..|.|.|||.::|....|:||..|::..|.:..:...
Mouse     2 SVVGIDLGFQSCYVAVARAG-GIETIANEYSDRCTPACVSFGPKNRSIGAAAKSQVISNAKNTVQ 65

  Fly    86 YLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNT---VVFRKSDTDEFSVEELVAQLLVKAKQF 147
            ......|:...:|.|:..:.... |:||..|...|   |.:.:.:.: |:.|::.|.||.|.|:.
Mouse    66 GFKRFHGRAFSDPFVEAEKSNLA-YDIVQLPTGLTGIKVTYMEEERN-FTTEQVTAMLLSKLKET 128

  Fly   148 AQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRG--EINE 210
            |:..:::|:.:||::||.::..|||.:::.|.|:|.|..|:|:|:..||||.||::.:.  .:.|
Mouse   129 AESVLKKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEE 193

  Fly   211 TAQYFLFYDMG--AYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQ 273
            ..:..:|.|||  ||:.|....:    |.|        ::||...:|.||||.:....|.::..:
Mouse   194 KPRNVVFVDMGHSAYQVSVCAFN----KGK--------LKVLATAFDTTLGGRKFDEVLVNHFCE 246

  Fly   274 EFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSAN-TEFFAQIENLIEDIDFKLPVTREKLEQL 337
            ||.  ||.|.|:.:..|||.:|.:|..:||.::||| ::....||..:.|||....:.|.|..::
Mouse   247 EFG--KKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEM 309

  Fly   338 CEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQELGKNLNADESATM 402
            |:||..|...||...|..|.|..:.|..|.:.||.||:|.|:|.|.....:||...|||||:.|.
Mouse   310 CDDLLARVEPPLRSVLEQSKLKKEDIYAVEIVGGATRIPAVKEKISKFFGKELSTTLNADEAVTR 374

  Fly   403 GAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITF- 466
            |...:.|.||..|||::|.:.|...:|:.:.:.....:|.:..:|    |...:..|..||:||
Mouse   375 GCALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGLSDCEV----FPKNHAAPFSKVLTFY 435

  Fly   467 NKHTDDFEFYVN------YAD--LDRYSKEEIAALGSLNVTKVQLK---QVKELLEKSKKELVDN 520
            .|.....|.|.:      |.|  :.::|.:::......:.:||::|   .|..:...|...||:
Mouse   436 RKEPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVE- 499

  Fly   521 KGIKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEE 585
                                  |::.::.|:..:.|..            .||.|:.:.:.|:..
Mouse   500 ----------------------VHKSEESEEPMETDQN------------AKEEEKMQVDQEEPH 530

  Fly   586 AANAGEEPSKSEDNEKAKEE-DASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPL 649
            .....::|....:|:...|| :.|:....::.|.|..:||...:|..||..|:..:...|....:
Mouse   531 TEEQQQQPQTPAENKAESEEMETSQAGSKDKKTDQPPQAKKAKVKTSTVDLPIESQLLWQLDREM 595

  Fly   650 VGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECS 714
            :| .|.::..|:...:|.|::|   ..|.||:|.::.|::.||..| |.|..:.:::.....:..
Mouse   596 LG-LYTENEGKMIMQDKLEKER---NDAKNAVEEYVYEMRDKLSGE-YEKFVSEDDRNTFTLKLE 655

  Fly   715 TLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAEKFLVTGRN 779
            ....|||||.||...::|.:|||:||.|......|..|.||||:..:.|...|....|.:.:.:|
Mouse   656 DTENWLYEDGEDQPKQVYVDKLAELKSLGQPIKTRFQESEERPKLFEELGKQIQQYMKVISSFKN 720

  Fly   780 LTKDTNPEKDVFTQVEIDTLDKVITETN---AWLKTETAAQKKLAKNADIRLTVKDITDKMSLLD 841
                   ::|.:..::...:.||...||   .|:.::...|.|.:...|..:..|:|..|:..|.
Mouse   721 -------KEDQYEHLDAADVTKVEKSTNEAMEWMNSKLNLQNKQSLTVDPVVKTKEIEAKIKELT 778

  Fly   842 REVKYLVNKIKIWKPKVKPAAEKEKKKEEEVVASGSGDDTKSEDAEQQQEQATKEEQQEQEPVDE 906
            .....:::|.   ||||:|..|:.|..|:.....|.||:..|:.||...:
Mouse   779 SICSPIISKP---KPKVEPPKEEPKHAEQNGPVDGQGDNPGSQAAEHGAD--------------- 825

  Fly   907 ITPTPAEEETKTPHSEL 923
             |..|::.:.|.|..::
Mouse   826 -TAVPSDGDKKLPEMDI 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	172/623 (28%)
		HYOU1-like_NBD	23..409	CDD:212672	126/393 (32%)
		TAF4	<572..>627	CDD:296797	13/55 (24%)
Hspa4	NP_032326.3	HSPA4_NBD	2..384	CDD:212687	128/398 (32%)
		HSP70	3..609	CDD:278441	181/662 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..577		17/88 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..842		19/77 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810