DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and Hsph1

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	XP_006504979.1	Gene:	Hsph1 / 15505	MGIID:	105053	Length:	877	Species:	Mus musculus

Alignment Length:	878	Identity:	242/878 - (27%)
Similarity:	402/878 - (45%)	Gaps:	117/878 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 AILAFRDGTRTIGEDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERN-T 120
            ::::|....||||..|:...|...|:.........|:..::|.:...::... |::|  |.:| .
Mouse    56 SVISFGSKNRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEKENLS-YDLV--PMKNGG 117

  Fly   121 VVFRKSDTDE---FSVEELVAQLLVKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLA 182
            |..:....||   ||||::.|.||.|.|:.|:.::::|:|:||::||.:|..|||.::|.|||:.
Mouse   118 VGIKVMYMDEEHFFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIV 182

  Fly   183 NLKVLQLINDYAAVALNYGVFHRGEIN--ETAQYFLFYDMG--AYKTSAAVVSYQLVKDKQTREI 243
            .|..|:|:||..|||||||::.:...|  |..:..:|.|||  :::.||...:    |.|
Mouse   183 GLNCLRLMNDMTAVALNYGIYKQDLPNAEEKPRVVVFVDMGHSSFQVSACAFN----KGK----- 238

  Fly   244 NPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSA 308
               ::|||..:|..|||.....:|.::...||..  |.|.|..:..|||.:|.:|..:||.::|:
Mouse   239 ---LKVLGTAFDPFLGGKNFDEKLVEHFCAEFKT--KYKLDAKSKIRALLRLHQECEKLKKLMSS 298

  Fly   309 N-TEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGG 372
            | |:....||..:.|.|....:.|.:.|:||.:|..:...||...:|.:.|..:.::.:.:.||.
Mouse   299 NSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLHSLMAQTQLKAEDVSAIEIVGGA 363

  Fly   373 TRVPRVQETIKAVIKQELGKNLNADESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERD 437
            ||:|.|:|.|.....:::...|||||:...|...:.|.||..|||::|.|.||..||:.:.:..|
Mouse   364 TRIPAVKERIAKFFGKDVSTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLVWNHD 428

  Fly   438 PGDGAAVKQVKRALFALMNPYPQKKVITFNKHTDDFEFYVNYAD----------LDRYSKEEIAA 492
            ..:...|.:|    |:..:..|..||:||.:. ..||....|:|          :.|:..:.::|
Mouse   429 SEETEGVHEV----FSRNHAAPFSKVLTFLRR-GPFELEAFYSDPQGVPYPEAKIGRFVVQNVSA 488

  Fly   493 LGSLNVTKVQLK-----------QVKELLEKSKKELVDNKGIKAYFYLDDSGIFRCTGVEYVYEK 546
            ......::|::|           ....::||...|..|...::|               :.....
Mouse   489 QKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEEEDGSSLEA---------------DMECPN 538

  Fly   547 QKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEPSKSEDNEKAKEEDASKEQ 611
            |:|.:.:|.|..:                 ::||||      ||.:|....|.::..:...|.|.
Mouse   539 QRPTESSDVDKNI-----------------QQDNSE------AGTQPQVQTDGQQTSQSPPSPEL 580

  Fly   612 KSEESTKQDT------------EAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSVAKLAAI 664
            .||||...|.            |||...||:|.|:.||......|....|: :.|.::..|:...
Mouse   581 TSEESKTPDADKANEKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGRDLL-NMYIETEGKMIMQ 644

  Fly   665 NKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYEDLEDPKA 729
            :|.|::|   ..|.||:|..:.|.:.||. ..|.|....:|.||.|...:...:||||:.||...
Mouse   645 DKLEKER---NDAKNAVEECVYEFRDKLC-GPYEKFICEQEHEKFLRLLTETEDWLYEEGEDQAK 705

  Fly   730 EIYEEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAEKFLVTGRNLTKDTNPEK-DVFTQ 793
            :.|.:||.:|.|:......|..|.||||:.::.|...:....|.....|.  ||   || :...:
Mouse   706 QAYIDKLEELMKMGTPVKVRFQEAEERPKVLEELGQRLQHYAKIAADFRG--KD---EKYNHIDE 765

  Fly   794 VEIDTLDKVITETNAWLKTETAAQKKLAKNADIRLTVKDITDKMSLLDREVKYLVN--KIKIWKP 856
            .|:..::|.:.|...|:.....||.|.:.:.|..:...:|..|:..|:...:.:|.  |.||..|
Mouse   766 SEMKKVEKSVNEVMEWMNNVMNAQAKRSLDQDPVVRTHEIRAKVKELNNVCEPVVTQPKPKIESP 830

  Fly   857 KVK--PAAEKEKKKEEEVVASGSGDDTKSEDAE 887
            |::  |......|||:....:..|.:...::.|
Mouse   831 KLERTPNGPNIDKKEDLEGKNNLGAEAPHQNGE 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	168/609 (28%)
		HYOU1-like_NBD	23..409	CDD:212672	113/360 (31%)
		TAF4	<572..>627	CDD:296797	18/66 (27%)
Hsph1	XP_006504979.1	NBD_sugar-kinase_HSP70_actin	56..403	CDD:388382	114/363 (31%)
		FtsN	<537..>620	CDD:225629	28/105 (27%)
		DUF4127	<673..761	CDD:379257	30/92 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810