DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and Hspa1l

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_038586.2	Gene:	Hspa1l / 15482	MGIID:	96231	Length:	641	Species:	Mus musculus

Alignment Length:	752	Identity:	181/752 - (24%)
Similarity:	327/752 - (43%)	Gaps:	151/752 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IALSQGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIK 78
            :|.::|.|: .:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....
Mouse     1 MAANKGMAI-GIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAM 63

  Fly    79 DPNSAYGYLLDLLGKTIDNPIVDLYRKRFPY--YNIVGDPERNTVVFRKSDTDEFSVEELVAQLL 141
            :|.:.......|:|:..::|:|....|.:|:  .|..|.|:  .:|..|.:...|..||:.:.:|
Mouse    64 NPQNTVFDAKRLIGRKFNDPVVQSDMKLWPFQVINEAGKPK--VMVSYKGEKKAFYPEEISSMVL 126

  Fly   142 VKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRG 206
            .|.|:.|:..:...:|..|:|||.||..::|:|...|..:|.|.||::||:..|.|:.||: .:|
Mouse   127 TKMKETAEAFLGHNVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGL-DKG 190

  Fly   207 EINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYL 271
            ...|  ::.|.:|:|......::::..          :.:.:|.....|..|||.:...||..:.
Mouse   191 SHGE--RHVLIFDLGGGTFDVSILTID----------DGIFEVKATAGDTHLGGEDFDNRLVSHF 243

  Fly   272 AQEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQ 336
            .:||.  :|.|.|::.:.||:.:|.....|.|..||::|:...:|::|.|.|||...:||.:.|:
Mouse   244 VEEFK--RKHKKDISQNKRAVRRLRTACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEE 306

  Fly   337 LCEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESA 400
            ||.||:....:|:|::|..:.:....|:.::|.||.||:|:||:.::.... ::|.|::|.||:.
Mouse   307 LCADLFRGTLEPVEKSLRDAKMDKAKIHDIVLVGGSTRIPKVQKLLQDYFNGRDLNKSINPDEAV 371

  Fly   401 TMGAVYKAADLSAGFKVKKFVVKDATLF---PLQVSFERDPGDGAAVKQVKRALFALMNPYPQKK 462
            ..||..:||.| .|.|.:|  |:|..|.   ||.:..|...|       |...|....:..|.|:
Mouse   372 AYGAAVQAAIL-MGDKSEK--VQDLLLLDVAPLSLGLETAGG-------VMTVLIKRNSTIPTKQ 426

  Fly   463 VITFNKHTDD-----FEFYVNYADLDRYSKEEIAALGSLNVTKV--QLKQVKELLEKSKKELVDN 520
            ...|..::|:     .:.|    :.:|....:...||..::|.:  ..:.|.:
Mouse   427 TQIFTTYSDNQPGVLIQVY----EGERAMTRDNNLLGRFDLTGIPPAPRGVPQ------------ 475

  Fly   521 KGIKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEE 585
              |:..|.:|.:||...|.::....|.......::...|||              |:.:...||.
Mouse   476 --IEVTFDIDANGILNVTAMDKSTGKANKITITNDKGRLSK--------------EEIERMVQEA 524

  Fly   586 AANAGEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLV 650
                          |:.|.||
Mouse   525 --------------ERYKAED-------------------------------------------- 531

  Fly   651 GSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECST 715
                             |.||.:: :|.||||::...::..:.:|......:..:|:|:|.:|:.
Mouse   532 -----------------EGQREKI-AAKNALESYAFNMKSAVGDEGLKDKISESDKKKILDKCNE 578

  Fly   716 LGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            :..||..:....|.| ::.|..:|:.:.|..:.:.::
Mouse   579 VLSWLEANQLAEKDE-FDHKRKELENMCNPIITKLYQ 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	158/615 (26%)
		HYOU1-like_NBD	23..409	CDD:212672	116/388 (30%)
		TAF4	<572..>627	CDD:296797	7/54 (13%)
Hspa1l	NP_038586.2	HSP70	3..641	CDD:331774	180/750 (24%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	3..388		123/404 (30%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	396..511		23/139 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810