Protein Alignment Grp170 and Hspa1l

DIOPT Version :10

• Sequence 1: NP_569995.1
• Gene: Grp170 / 31215
• FlyBaseID: FBgn0023529
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_038586.2
• Gene: Hspa1l / 15482
• MGIID: 96231
• Length: 641
• Species: Mus musculus
• Alignment Length: 753
• Identity: 181/753 - (24%)
• Similarity: 326/753 - (43%)
• Gaps: 153/753 - (20%)

  Fly    14 IALSQGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIK 78
            :|.::|.|: .:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....
Mouse     1 MAANKGMAI-GIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAM 63

  Fly    79 DPNSAYGYLLDLLGKTIDNPIVDLYRKRFPY--YNIVGDPERNTVVFRKSDTDEFSVEELVAQLL 141
            :|.:.......|:|:..::|:|....|.:|:  .|..|.|:  .:|..|.:...|..||:.:.:|
Mouse    64 NPQNTVFDAKRLIGRKFNDPVVQSDMKLWPFQVINEAGKPK--VMVSYKGEKKAFYPEEISSMVL 126

  Fly   142 VKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRG 206
            .|.|:.|:..:...:|..|:|||.||..::|:|...|..:|.|.||::||:..|.|:.||: .:|
Mouse   127 TKMKETAEAFLGHNVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGL-DKG 190

  Fly   207 EINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYL 271
            ...|  ::.|.:|:|......::::..          :.:.:|.....|..|||.:...||..:.
Mouse   191 SHGE--RHVLIFDLGGGTFDVSILTID----------DGIFEVKATAGDTHLGGEDFDNRLVSHF 243

  Fly   272 AQEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQ 336
            .:||.  :|.|.|::.:.||:.:|.....|.|..||::|:...:|::|.|.|||...:||.:.|:
Mouse   244 VEEFK--RKHKKDISQNKRAVRRLRTACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEE 306

  Fly   337 LCEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESA 400
            ||.||:....:|:|::|..:.:....|:.::|.||.||:|:||:.::.... ::|.|::|.||:.
Mouse   307 LCADLFRGTLEPVEKSLRDAKMDKAKIHDIVLVGGSTRIPKVQKLLQDYFNGRDLNKSINPDEAV 371

  Fly   401 TMGAVYKAADLSAGFKVKKFVVKDATLF---PLQVSFERDPGDGAAVKQVKRALFALMNPYPQKK 462
            ..||..:||.| .|.|.:|  |:|..|.   ||.:..|...|       |...|....:..|.|:
Mouse   372 AYGAAVQAAIL-MGDKSEK--VQDLLLLDVAPLSLGLETAGG-------VMTVLIKRNSTIPTKQ 426

  Fly   463 VITFNKHTDD-----FEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKG 522
            ...|..::|:     .:.|    :.:|....:...||..::|.:....               :|
Mouse   427 TQIFTTYSDNQPGVLIQVY----EGERAMTRDNNLLGRFDLTGIPPAP---------------RG 472

  Fly   523 ---IKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQE 584
               |:..|.:|.:||...|.::....|.......::...|||              |:.:...||
Mouse   473 VPQIEVTFDIDANGILNVTAMDKSTGKANKITITNDKGRLSK--------------EEIERMVQE 523

  Fly   585 EAANAGEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPL 649
            .              |:.|.||
Mouse   524 A--------------ERYKAED------------------------------------------- 531

  Fly   650 VGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECS 714
                              |.||.:: :|.||||::...::..:.:|......:..:|:|:|.:|:
Mouse   532 ------------------EGQREKI-AAKNALESYAFNMKSAVGDEGLKDKISESDKKKILDKCN 577

  Fly   715 TLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            .:..||..:....|.| ::.|..:|:.:.|..:.:.::
Mouse   578 EVLSWLEANQLAEKDE-FDHKRKELENMCNPIITKLYQ 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grp170	NP_569995.1	ASKHA_NBD_HSP70_HYOU1	21..409	CDD:466828	117/390 (30%)
		PTZ00121	<546..917	CDD:173412	31/207 (15%)
		TAF4	<572..>627	CDD:461598	7/54 (13%)
Hspa1l	NP_038586.2	PTZ00009	3..641	CDD:240227	180/751 (24%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		123/404 (30%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		23/140 (16%)