DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and AgaP_AGAP010331

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	XP_315285.3	Gene:	AgaP_AGAP010331 / 1275989	VectorBaseID:	AGAP010331	Length:	812	Species:	Anopheles gambiae

Alignment Length:	914	Identity:	215/914 - (23%)
Similarity:	399/914 - (43%)	Gaps:	132/914 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYG 85
            :|:.:|.|::...|.|...| .:|...|..|.|.||:.:||....|.:|..|:...:.:.|:..|
Mosquito     2 SVIGIDFGNDSSYVAVAKAG-GIETIANDYSLRATPSFVAFAGRNRVLGVAAKNQQVTNMNNTIG 65

  Fly    86 YLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDE---FSVEELVAQLLVKAKQF 147
            ...:|||:..|:|......:..||:...  .:...:..|.:..||   ||.|::.|.|..|.|:.
Mosquito    66 NFKELLGRKFDDPRAQEELRSLPYHTEA--LQDGGIGIRVNYLDEEHVFSPEQITAMLFTKLKED 128

  Fly   148 AQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRGEI---N 209
            |.:.::..|.:||:|||.||..|:|:|||.||.::.|.||:|:|:..|.||:|| |::.::   .
Mosquito   129 AFKELKTQINDCVITVPSYFTNAQRQALLDAANISGLNVLRLMNETTATALSYG-FYKQDLPAPE 192

  Fly   210 ETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQE 274
            |..:..:|.|.|......:..::.....|.....:.           ::||.:..|.|..:..:|
Mosquito   193 EKPRNVIFVDCGHASLQVSACAFHKGNLKMLASCSD-----------SVGGRDFDLVLATHFNKE 246

  Fly   275 FNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSAN-TEFFAQIENLIEDIDFKLPVTREKLEQLC 338
            |..  |.|.|.::..||..:|..|..:||..:||| |:....||..:.:||....:.|.::|:|.
Mosquito   247 FQT--KYKIDASSKKRAFLRLMAEVEKLKKNMSANSTKLPLNIECFMNEIDVHSSMQRSEMEELS 309

  Fly   339 EDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQELGKNLNADESATMG 403
            ..|..|....:.:.|..|.|:|:.|:.|.:.||.:|:|.::..|:.:..:.....||.||:.:.|
Mosquito   310 SHLLKRIETTMRKLLLDSKLALEEIHSVEIVGGSSRIPAIKHLIEQIFGKPASTTLNQDEAVSRG 374

  Fly   404 AVYKAADLSAGFKVKKFVVKDATLFPLQVSF-ERD-PGDGAAVKQVKRALFALMNPYPQKKVITF 466
            |..:.|.||...:|::|...|...:|:.:|: :.| |.:....:|...|.|..:....:|:.:|.
Mosquito   375 AALQCAILSPAVRVREFSCTDVQAYPVLISWTDTDGPHEMKVFEQYHAAPFCRLLTVHRKEPMTI 439

  Fly   467 NKHTDDFEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKGIKAYFYLDD 531
            ..|.:...  :.|.|         ..:|:.:|..::.....|..|...|..::|.||..
Mosquito   440 KVHYEPNS--IPYPD---------PFIGTYHVKGIKPDANGEAQEVKVKVRINNNGIIT------ 487

  Fly   532 SGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEPSKS 596
              :...|    :||:::.|:.:....|                    .|.:|::..:|.:...:.
Mosquito   488 --VSSAT----MYERKESEEPSSPTPT--------------------SNGDQQKTGDANQSSPQG 526

  Fly   597 EDNEKAKEE-DASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSVAK 660
            :::.|..|. |..:::|.:.:|||        ::|       |.:|.|...|......|.:...|
Mosquito   527 DESGKVGEPMDIQEDKKKKVTTKQ--------VEL-------TIDSNTHGFVHTELCKYFEEEMK 576

  Fly   661 LAAINKAEEQRVRLESAFNALEAHIIEVQQKLDE-----------ESYAKCATAEEKEKLLAECS 714
            :.|.::.|::|:   .|.||||..:.|:::|:.|           ::.|.|...||.|
Mosquito   577 MIANDRQEKERI---DARNALEEQVYEIREKIQEDGALHDYIDPQDASAICRELEETE------- 631

  Fly   715 TLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPEAI----KALKGMIDGAEKFLV 775
               .||||:.|..:..:|:|:|.:::...:....|..|...:.:|.    .|::..:...|::
Mosquito   632 ---NWLYEEGESCEKGVYKERLEKMRAKIDPVRNRCEEFNGQEQAFTDLGHAVQQTLKAVEQY-- 691

  Fly   776 TGRNLTKDTNPEKDVFTQVEIDTLDKVITETNAWLKTETAAQKKLA---KNADIRLTVKDITDKM 837
                  :...|:.:..|:.|:..:.:...:...|.:   .|:.||.   |..|..:.:.||..:.
Mosquito   692 ------RAKEPKYEHLTETEMINITEAAQKAQKWYE---EARSKLVGARKTEDPPVKLADIRHET 747

  Fly   838 SLLDREVKYLVNKIKIWKPKVKPAAEKEKKKEEEVVASG-SGDDTKSEDAEQQQEQATKEEQQEQ 901
            ..|......::|:.|. ||...||.:.::....   |:| :..||.:...:.|.....|:..::.
Mosquito   748 VTLTTCTNSVLNRPKP-KPPTPPADQNQQNGSS---ATGAASQDTHAPGNDNQDSNTPKQTTEDS 808

  Fly   902 EPVD 905
            ..|:
Mosquito   809 MDVE 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	154/612 (25%)
		HYOU1-like_NBD	23..409	CDD:212672	112/392 (29%)
		TAF4	<572..>627	CDD:296797	10/55 (18%)
AgaP_AGAP010331	XP_315285.3	HSPA4_like_NDB	2..383	CDD:212670	114/397 (29%)
AgaP_AGAP010331	XP_315285.3	HSP70	3..663	CDD:278441	185/747 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810