Protein Alignment Grp170 and Hsc70-3

DIOPT Version :10

• Sequence 1: NP_569995.1
• Gene: Grp170 / 31215
• FlyBaseID: FBgn0023529
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: XP_061503529.1
• Gene: Hsc70-3 / 1274027
• VectorBaseID: AGAMI1_006933
• Length: 659
• Species: Anopheles gambiae
• Alignment Length: 697
• Identity: 184/697 - (26%)
• Similarity: 306/697 - (43%)
• Gaps: 97/697 - (13%)

  Fly     1 MKLV--LLLSALLAGIALSQG---------AAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRK 54
            |||:  ..|..:||.:|.|..         ..|:.:|||:.:..|||...| .:||..|.:..|.
Mosquito     1 MKLLKQTALVVVLAVLACSAEEKKEKDKDIGTVVGIDLGTTYSCVGVYKNG-RVEIIANDQGNRI 64

  Fly    55 TPAILAF-RDGTRTIGEDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPER 118
            ||:.:|| .||.|.||:.|:.....:|.:.......|:|:...:..|....|..|:..|    |:
Mosquito    65 TPSYVAFTADGERLIGDAAKNQLTTNPENTVFDAKRLIGREFTDHTVQHDIKLLPFKVI----EK 125

  Fly   119 NTVVFRKSDTDE----FSVEELVAQLLVKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAA 179
            |:....:..|.:    |:.||:.|.:|.|.|:.|:..:.:.:|..|:|||.||..|:|:|...|.
Mosquito   126 NSKPHIRVSTGQGDKVFAPEEISAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAG 190

  Fly   180 QLANLKVLQLINDYAAVALNYGVFHR-GEINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREI 243
            .:|.|.|:::||:..|.|:.||:..: ||.|     .|.:|:|......::::..
Mosquito   191 TIAGLVVMRIINEPTAAAIAYGLDKKDGEKN-----VLVFDLGGGTFDVSLLTID---------- 240

  Fly   244 NPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSA 308
            |.|.:|:....|..|||.:...|:.|:..:.:.  ||...|:....||:.||.:|..:.|..|||
Mosquito   241 NGVFEVVATNGDTHLGGEDFDQRVMDHFIKMYK--KKKGKDIRKDNRAVQKLRREVEKAKRALSA 303

  Fly   309 NTEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGGT 373
            :.:...:||:..|..||...:||.|.|:|..||:....||:.:.|..:.::.:.:::::|.||.|
Mosquito   304 SHQVRIEIESFFEGDDFSETLTRAKFEELNMDLFRSTMKPVHKVLEDADMTKNDVDEIVLVGGST 368

  Fly   374 RVPRVQETIKAVIK-QELGKNLNADESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERD 437
            |:|:||:.:|.... :|..:.:|.||:...||..:|..||........|:.|..  ||.:..|
Mosquito   369 RIPKVQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGEQDTDAIVLLDVN--PLTMGIE-- 429

  Fly   438 PGDGAAVKQVKRALFALMNPYPQKKVITF-----NKHTDDFEFYVNYADLDRYSKEEIAALGSLN 497
                 .|..|...|.......|.||...|     |:||...:.|    :.:|...::...||..:
Mosquito   430 -----TVGGVMTKLIPRNTVIPTKKSQIFSTASDNQHTVTIQVY----EGERPMTKDNHLLGKFD 485

  Fly   498 VTKVQ-----LKQVKELLEKSKKELVDNKGIKAYFYLDDSGIFRCTGVEYVYEKQK--PEDDADE 555
            :|.:.     :.|::...|      :|..|| .....:|.|......:....::.:  |:|....
Mosquito   486 LTGIPPAPRGIPQIEVSFE------IDANGI-LQVSAEDKGTGNREKIVITNDQNRLTPDDIERM 543

  Fly   556 DSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEPSKSE------DNEKAKEEDASKEQKSE 614
            .....:|.....||  ||..|.::..|....:...:..||.:      |::|||.|:|..|:...
Mosquito   544 IKDAERFADDDKKL--KERVEARNELESYAYSLKNQLSSKDKLGASVSDDDKAKMEEAIDEKIKW 606

  Fly   615 ESTKQDTEAKNETIKLVTVKSPVTYESQTQ----FVVPLVGSAYDQS 657
            ....|||||:.             |:.|.:    .|.|::...|..|
Mosquito   607 LDENQDTEAEE-------------YKKQKKELEDIVQPIITKLYASS 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grp170	NP_569995.1	ASKHA_NBD_HSP70_HYOU1	21..409	CDD:466828	117/394 (30%)
		PTZ00121	<546..917	CDD:173412	29/124 (23%)
		TAF4	<572..>627	CDD:461598	18/60 (30%)
Hsc70-3	XP_061503529.1	None