DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and HSPA12B

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_443202.3	Gene:	HSPA12B / 116835	HGNCID:	16193	Length:	686	Species:	Homo sapiens

Alignment Length:	153	Identity:	38/153 - (24%)
Similarity:	60/153 - (39%)	Gaps:	41/153 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 KRKTPA-----ILAFRDGTRTIG-EDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYY 110
            ||:.||     .:||....||.| ..|..:.|..|.|                .:|.|||: ..:
Human   377 KRQRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFS----------------FIDFYRKQ-RGH 424

  Fly   111 NIVGDPERNTVVFRKSDTDEFSVEELVAQLLVKAKQFAQESVQQPITECVLTVPGYFGQAEREAL 175
            |:.....|::|.|.|..          :|.:::....|...:.||      ||.|.....  |||
Human   425 NVETALRRSSVNFVKWS----------SQGMLRMSCEAMNELFQP------TVSGIIQHI--EAL 471

  Fly   176 LSAAQLANLKVLQLINDYAAVAL 198
            |:..::..:|:|.|:..:|..|:
Human   472 LARPEVQGVKLLFLVGGFAESAV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	38/153 (25%)
		HYOU1-like_NBD	23..409	CDD:212672	38/153 (25%)
		TAF4	<572..>627	CDD:296797
HSPA12B	NP_443202.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..53
HSPA12B	NP_443202.3	NBD_sugar-kinase_HSP70_actin	61..529	CDD:327376	38/153 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900