DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and Hspa13

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_084477.1	Gene:	Hspa13 / 110920	MGIID:	1309463	Length:	471	Species:	Mus musculus

Alignment Length:	484	Identity:	111/484 - (22%)
Similarity:	206/484 - (42%)	Gaps:	95/484 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLSALLAGIALSQ-----GAAVMSVDLGSEWMKVGVVSPGV-PMEIALNRESKRKTPAILAFRDG 64
            :|:.||||....|     ...|:.:|||:.:..|||..||. .:::..:.......|::::|.||
Mouse    12 VLTLLLAGYLAQQYLPLPTPKVIGIDLGTTYCSVGVFFPGTGKVKVIPDENGHISIPSMVSFTDG 76

  Fly    65 TRTIGEDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTD 129
            ...:|.::..:...:|.:........:||......::....|:|:           .|..::...
Mouse    77 DVYVGYESLELADSNPQNTIYDAKRFIGKIFTPEELEAEVGRYPF-----------KVLHRNGMA 130

  Fly   130 EFSV----------EELVAQLLVKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANL 184
            ||||          |.:.::||:|.|:.|:|.:..|:...|::||..|...:|.:.:.||.||.|
Mouse   131 EFSVTSNETIIVSPEFVGSRLLLKLKEMAEEYLGMPVANAVISVPAEFDLQQRNSTIQAANLAGL 195

  Fly   185 KVLQLINDYAAVALNYGVFHRGEINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQV 249
            |:|::||:..|.|:.||: |:.::    .|.|..|:|......::::.|          ..:...
Mouse   196 KILRVINEPTAAAMAYGL-HKVDV----FYVLVIDLGGGTLDVSLLNKQ----------GGMFLT 245

  Fly   250 LGVGYDRTLGGLEIQLRLRDYLAQEF------------------NALKKTKTDVT--TSPRALAK 294
            ..:..:..|||.:...||..:|.:|.                  .|::..|.::|  .|.:....
Mouse   246 RAMSGNNKLGGQDFNQRLLQHLYKEIYQTYGFLPSRKEEIHRLRQAVEMVKLNLTIHQSAQVSVL 310

  Fly   295 LFKEAGRLKNVLSANTEF--------------------FAQIENLIEDIDFKLPVTREKLEQLCE 339
            |..|....|...:.::|.                    .::.::....:.|:..|:|:..:.|.|
Mouse   311 LTVEGKDSKEPQNGDSELPKDQLTPGDGHHVNRVFRPGLSESKSGKSQVLFETEVSRKLFDALNE 375

  Fly   340 DLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQELGKNLNADESATMGA 404
            ||:.:...|:::.|....|....|::|:|.||.||:||:::    ||::..||:.|......: |
Mouse   376 DLFQKILVPIQQVLKEGLLDKTEIDEVVLVGGSTRIPRIRQ----VIQEFFGKDPNTSVDPDL-A 435

  Fly   405 VYKAADLSAGFKVKKFVVKDATLFPLQVS 433
            |.....:.||.        |...:|||||
Mouse   436 VVTGVAIQAGI--------DGGSWPLQVS 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	105/463 (23%)
		HYOU1-like_NBD	23..409	CDD:212672	96/436 (22%)
		TAF4	<572..>627	CDD:296797
Hspa13	NP_084477.1	HSPA13-like_NBD	12..463	CDD:212679	111/484 (23%)
		PRK13930	32..442	CDD:237564	97/440 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..350		2/32 (6%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900