DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and HSPH1

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001273433.1	Gene:	HSPH1 / 10808	HGNCID:	16969	Length:	860	Species:	Homo sapiens

Alignment Length:	888	Identity:	249/888 - (28%)
Similarity:	404/888 - (45%)	Gaps:	122/888 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 AILAFRDGTRTIGEDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERN-- 119
            ::::|....||||..|:...|...|:.........|:..::|.:...::... |::|  |.:|
Human    39 SVISFGSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLS-YDLV--PLKNGG 100

  Fly   120 --TVVFRKSDTDEFSVEELVAQLLVKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLA 182
              ..|....:...||||::.|.||.|.|:.|:.|:::|:|:||::||.:|..|||.::|.|||:.
Human   101 VGIKVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIV 165

  Fly   183 NLKVLQLINDYAAVALNYGVFHRG--EINETAQYFLFYDMG--AYKTSAAVVSYQLVKDKQTREI 243
            .|..|:|:||..|||||||::.:.  .::|..:..:|.|||  |::.||...:    |.|
Human   166 GLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFN----KGK----- 221

  Fly   244 NPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSA 308
               ::|||..:|..|||.....:|.::...||..  |.|.|..:..|||.:|::|..:||.::|:
Human   222 ---LKVLGTAFDPFLGGKNFDEKLVEHFCAEFKT--KYKLDAKSKIRALLRLYQECEKLKKLMSS 281

  Fly   309 N-TEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGG 372
            | |:....||..:.|.|....:.|.:.|:||.:|..:...||...|..:||.::.::.|.:.||.
Human   282 NSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGA 346

  Fly   373 TRVPRVQETIKAVIKQELGKNLNADESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERD 437
            ||:|.|:|.|.....:::...|||||:...|...:.|.||..|||::|.|.||..||:.:.:..|
Human   347 TRIPAVKERIAKFFGKDISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLIWNHD 411

  Fly   438 PGDGAAVKQVKRALFALMNPYPQKKVITFNKHTDDFEFYVNYADLDRYSKEEIAALGSLNVTKVQ 502
            ..|...|.:|    |:..:..|..||:||.:. ..||....|:|.......| |.:|...|..|.
Human   412 SEDTEGVHEV----FSRNHAAPFSKVLTFLRR-GPFELEAFYSDPQGVPYPE-AKIGRFVVQNVS 470

  Fly   503 LKQVKELLEKSKKELVDNKGIKAYFYLDDSGIFRCTGVEYVYEK------------------QKP 549
            .::..   |||:        :|....::..|||..:....| ||                  |:|
Human   471 AQKDG---EKSR--------VKVKVRVNTHGIFTISTASMV-EKVPTEENEMSSEADMECLNQRP 523

  Fly   550 EDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEPSKSEDNEKAKEEDASKEQKSE 614
            .::.|.|..:                 ::||||      ||.:|....|.::..:...|.|..||
Human   524 PENPDTDKNV-----------------QQDNSE------AGTQPQVQTDAQQTSQSPPSPELTSE 565

  Fly   615 ES------------TKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSVAKLAAINKA 667
            |:            ..|..|||...||:|.|:.|:......|....|: :.|.::..|:...:|.
Human   566 ENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKDLL-NMYIETEGKMIMQDKL 629

  Fly   668 EEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYEDLEDPKAEIY 732
            |::|   ..|.||:|.::.|.:.||. ..|.|....::.:..|...:...:||||:.||...:.|
Human   630 EKER---NDAKNAVEEYVYEFRDKLC-GPYEKFICEQDHQNFLRLLTETEDWLYEEGEDQAKQAY 690

  Fly   733 EEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAEKFLVTGRNLTKDTNPEK-DVFTQVEI 796
            .:||.:|.|:......|..|.||||:..:.|...:....|.....||  ||   || :...:.|:
Human   691 VDKLEELMKIGTPVKVRFQEAEERPKMFEELGQRLQHYAKIAADFRN--KD---EKYNHIDESEM 750

  Fly   797 DTLDKVITETNAWLKTETAAQKKLAKNADIRLTVKDITDKMSLLDREVKYLVN--KIKIWKPKVK 859
            ..::|.:.|...|:.....||.|.:.:.|..:..::|..|:..|:...:.:|.  |.||..||:
Human   751 KKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTKIKELNNTCEPVVTQPKPKIESPKL- 814

  Fly   860 PAAEKEKKKEEEVVASGSGDDTKSEDAEQQQEQATKEEQQEQE 902
                       |...:|...|.|.||.|.:.....:...|..|
Human   815 -----------ERTPNGPNIDKKEEDLEDKNNFGAEPPHQNGE 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	175/606 (29%)
		HYOU1-like_NBD	23..409	CDD:212672	114/360 (32%)
		TAF4	<572..>627	CDD:296797	17/66 (26%)
HSPH1	NP_001273433.1	NBD_sugar-kinase_HSP70_actin	39..386	CDD:327376	115/363 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810