DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and hsp70.2

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001349289.1	Gene:	hsp70.2 / 100535101	ZFINID:	ZDB-GENE-110405-1	Length:	643	Species:	Danio rerio

Alignment Length:	744	Identity:	182/744 - (24%)
Similarity:	335/744 - (45%)	Gaps:	143/744 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNS 82
            :|.|: .:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:||:
Zfish     5 KGIAI-GIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPNN 67

  Fly    83 AYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTV-VFRKSDTDEFSVEELVAQLLVKAKQ 146
            .......|:|:..|:|:|....|.:. :.:|.|..:..| |..|.:...|:.||:.:.:|||.|:
Zfish    68 TVFDAKRLIGRRFDDPVVQSDMKHWS-FKVVSDGGKPKVAVEHKGENKTFNPEEISSMVLVKMKE 131

  Fly   147 FAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRGEINET 211
            .|:..:.|.:|..|:|||.||..::|:|...|..:|.|.||::||:..|.|:.||: .:|:.:|
Zfish   132 IAEAYLGQKVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGL-DKGKSSE- 194

  Fly   212 AQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFN 276
             :..|.:|:|......::::.:          :.:.:|.....|..|||.:...|:.::..:||.
Zfish   195 -RNVLIFDLGGGTFDVSILTIE----------DGIFEVKATAGDTHLGGEDFDNRMVNHFVEEFK 248

  Fly   277 ALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDL 341
              :|.|.|::.:.|||.:|.....|.|..||::::...:|::|.|.|||...:||.:.|:||.||
Zfish   249 --RKHKKDISQNKRALRRLRTACERAKRTLSSSSQASIEIDSLYEGIDFYTSITRARFEELCSDL 311

  Fly   342 WPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESATMGAV 405
            :.....|:|:||..:.:....|:.::|.||.||:|::|:.::.... :||.|::|.||:...||.
Zfish   312 FRGTLDPVEKALRDAKMDKAQIHDIVLVGGSTRIPKIQKLLQDFFNGRELNKSINPDEAVAYGAA 376

  Fly   406 YKAADL---SAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITFN 467
            .:||.|   ::| .|:..::.|..  ||.:..|...|       |..||.......|.|:..||:
Zfish   377 VQAAILMGDTSG-NVQDLLLLDVA--PLSLGIETAGG-------VMTALIKRNTTIPTKQTQTFS 431

  Fly   468 KHTDDFE-FYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKG---IKAYFY 528
            .::|:.. ..:...:.:|...::...||...:|.:....               :|   |:..|.
Zfish   432 TYSDNQPGVLIQVFEGERAMTKDNNLLGKFELTGIPPAP---------------RGVPQIEVTFD 481

  Fly   529 LDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEP 593
            :|.:||...:..:....||......::...|||              |:.:...||
Zfish   482 IDANGILNVSAADKSTGKQNKITITNDKGRLSK--------------EEIERMVQE--------- 523

  Fly   594 SKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSV 658
               .||.|| |:|..:|:
Zfish   524 ---ADNYKA-EDDLQREK----------------------------------------------- 537

  Fly   659 AKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYED 723
                            .||.|:||::...::..:::::.....:.|:|::::.:|:....|| |:
Zfish   538 ----------------ISAKNSLESYAFNMKNSVEDDNLKGKISEEDKKRVIEKCNEAVSWL-EN 585

  Fly   724 LEDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            .:....|.||.:|.:|:|:.|..:::.::
Zfish   586 NQLADKEEYEHQLKELEKVCNPVISKLYQ 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	162/611 (27%)
		HYOU1-like_NBD	23..409	CDD:212672	119/387 (31%)
		TAF4	<572..>627	CDD:296797	10/54 (19%)
hsp70.2	NP_001349289.1	HSP70	5..643	CDD:331774	182/744 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910