DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and tut7

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001297032.1	Gene:	tut7 / 100327236	XenbaseID:	XB-GENE-986060	Length:	1515	Species:	Xenopus tropicalis

Alignment Length:	1104	Identity:	214/1104 - (19%)
Similarity:	355/1104 - (32%)	Gaps:	371/1104 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LVLLLSALLAGIALSQGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKR-KTPAILAFRDGTR 66
            |.:.|.|.:...::||.|....:|...::: |...:.....||..|.||.| |:|.:.:
Frog   461 LPVYLGAWIEDFSVSQLAKYTLLDTEKDYV-VWECNTAADREIHPNEESVRGKSPLVFS------ 518

  Fly    67 TIGEDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDEF 131
               ...|.|      ::.|:|.           :|:.|    :|::                 ||
Frog   519 ---APHQCI------ASTGHLW-----------IDMLR----FYSL-----------------EF 542

  Fly   132 SVEELVAQLLVKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAV 196
            ::.:||..:.||.| .::||...|.....:..|....:....:|.|          ||:.||
Frog   543 NMADLVISIRVKEK-ISRESKDWPKKRIAVEDPYSVKRNVARSLNS----------QLMYDY--- 593

  Fly   197 ALNYGVFHRGEINETAQYFLFYDMGAYKTSA--AVVSYQLVKDKQTREINPVVQVLGVGYDRTLG 259
                 :||.  :..|.:||..:...:.|.|.  ...|..:..:.....:|.:.:..||  || :.
Frog   594 -----IFHC--LRATYKYFAMHQKRSTKASQKHTTQSGAIADNPSESSLNALNEAKGV--DR-MA 648

  Fly   260 GLEIQLRLRDYLAQEFNALKKTKTDVTTSPRA-------------LAKLFKEAGRLKNVLSANTE 311
            ||..||              :.....|.||||             ..::.|..|:.|..|..:|.
Frog   649 GLNKQL--------------EELVIGTDSPRASVQNNQKFHQSPSCKEVDKAYGQTKRKLVYDTM 699

  Fly   312 FFAQI----ENLIEDIDFKLPVTREKLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGG 372
            ....:    :.:||:|   :....|...:.||:: .......||.....|
Frog   700 STNSVPEDPDCIIEEI---ISCDPEDSVESCEEV-ESCNDESEEEDFPMH--------------- 745

  Fly   373 TRVPRVQETIKAVIKQELGKNLNADESATMGAVYKAAD-----LSAGFKVKKFVVKDATLFPLQV 432
              ||.....:..:|...|      ||.:..|.|.:||:     ||   .|::|.  :|.| |...
Frog   746 --VPTKDSKVDYIIDPGL------DEDSETGEVLRAANEETDSLS---DVEEFT--NAAL-PEPE 796

  Fly   433 SFERDPG------DGAAVKQVKRALFALMNPYPQK------KVITFNKHTDDFEFYVNYADLD-R 484
            .|..|.|      |..:.:....     :...|.:      |..|.||..|:.|   :..|.| .
Frog   797 DFVFDSGGTQNVVDEESTEGTDE-----LEEIPSEFITQTMKQATSNKFDDEEE---DDGDDDIH 853

  Fly   485 YSKEEIAAL-----------GSLNVTKVQLKQVKELL-----EKSKKELVDNKGIKAYFYLDDSG 533
            |.::.:.:|           ||::          |.|     |:..||..|        |:..|
Frog   854 YPRDHLDSLTADEDMEHTYTGSMD----------ECLSDNDAEEDDKEPPD--------YVVPS- 899

  Fly   534 IFRCTGVEYVYEKQKP-----EDDADEDSTL----SKFGSTLSKLFT-------KEGEEKKDNSE 582
             .:...|...::||:|     .|...||:.|    :|...|..||.|       :||..|::..|
Frog   900 -VKPLPVTENFDKQEPVQTEIVDTVAEDNVLLYEFNKLAFTRGKLPTIVCNLCKREGHLKRECPE 963

  Fly   583 QEEAANAGEEPSKSEDNEKAKE-------EDASK---EQKSEESTKQDTEAKNETIKLVTVKSPV 637
            ..:.......|..:....|..:       ||.|.   |.|:.|..:||.|.        .:|...
Frog   964 DFKKIELDPLPPLTSKFRKILDAVCIQCYEDFSPTALEDKAREHIRQDLED--------FIKRDF 1020

  Fly   638 TYESQTQFVVPLVGSAYDQS----VAKLAAINKAEE-QRVR-LESAFNALEAH------------ 684
            :..|.|.|.....|..:.||    ...:..:..||| ..:| :|.....|..|
Frog  1021 SGASLTLFGSSKNGFGFKQSDLDICMTIDGLETAEELDSIRTIEDLARLLRKHQGLRNILPITTA 1085

  Fly   685 ------IIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYEDLEDPK--------------A 729
                  ...|:..|:.:.......|....:|||..:.:         ||:              .
Frog  1086 KVPIVKFYHVRSGLEGDISLYNTLALHNTRLLASFAAI---------DPRVTYLCYIMKVFTKMC 1141

  Fly   730 EIYEEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAEK--FLVTGRNLTKDTNPEKDVFT 792
            :|.:.....|...:...:..::..:..|..|..|:.:..|.:|  .:|.|.|:
Frog  1142 DIGDASRGSLSSYAYTLMVLYFLQQRNPPVIPVLQEICKGQKKPEIIVDGWNV------------ 1194

  Fly   793 QVEIDTLDKVITE-----------TNAWL-----KTE---------TAAQKKLAKNADIRLTVKD 832
             ...|.||::.:.           ...||     .||         :..:|.|......:.|.|.
Frog  1195 -YFFDKLDELASHWPEFGQNKESVGELWLGLLRFYTEDFDFKEHVISIRRKNLLTTFKKQWTSKY 1258

  Fly   833 IT--DKMSL-------LDRE-----VKYLVNKIKIWKPKVKPAAEKEKKKEE-----EVVASG-- 876
            |.  |...|       |.|:     :|..:|..:::...||...::...|.|     ||:..|
Frog  1259 IVIEDPFDLNHNLGAGLSRKMTNFIMKAFINGRRVFGTPVKNFPKEYPTKMEYFFDPEVLTEGEL 1323

  Fly   877 SGDD------------------------TKSEDAEQQQEQATKEEQQEQEPVDEITPTPAEEET 916
            :.:|                        .|:|:|..|:...|:.::..:|...:    .||.||
Frog  1324 APNDRCCRICGKIGHFMKDCPMRRKVRRRKNENAGNQRYPETRNQRMTEEAASK----GAENET 1383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	140/682 (21%)
		HYOU1-like_NBD	23..409	CDD:212672	78/405 (19%)
		TAF4	<572..>627	CDD:296797	15/64 (23%)
tut7	NP_001297032.1	PTZ00368	<1323..1466	CDD:173561	11/65 (17%)
		TUTF7_u4	1346..1431	CDD:318772	10/42 (24%)
		TRF4	230..>461	CDD:227585	214/1104 (19%)
		NT_PAP_TUTase	302..410	CDD:143392
		PAP_assoc	528..575	CDD:367682	15/79 (19%)
		TRF4	958..>1293	CDD:227585	63/364 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900