DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and hsp70.1

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001349288.1	Gene:	hsp70.1 / 100126123	ZFINID:	ZDB-GENE-990415-91	Length:	643	Species:	Danio rerio

Alignment Length:	750	Identity:	179/750 - (23%)
Similarity:	332/750 - (44%)	Gaps:	155/750 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNS 82
            :|.|: .:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:||:
Zfish     5 KGIAI-GIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPNN 67

  Fly    83 AYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTV-VFRKSDTDEFSVEELVAQLLVKAKQ 146
            .......|:|:..|:|:|....|.:. :.:|.|..:..| |..|.:...|:.||:.:.:|||.|:
Zfish    68 TVFDAKRLIGRRFDDPVVQSDMKHWS-FKVVSDGGKPKVAVEHKGENKTFNPEEISSMVLVKMKE 131

  Fly   147 FAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRGEINET 211
            .|:..:.|.:|..|:|||.||..::|:|...|..:|.|.||::||:..|.|:.||: .:|:.:|
Zfish   132 IAEAYLGQKVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGL-DKGKSSE- 194

  Fly   212 AQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFN 276
             :..|.:|:|......::::.:          :.:.:|.....|..|||.:...|:.::..:||.
Zfish   195 -RNVLIFDLGGGTFDVSILTIE----------DGIFEVKATAGDTHLGGEDFDNRMVNHFVEEFK 248

  Fly   277 ALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDL 341
              :|.|.|::.:.|||.:|.....|.|..||::::...:|::|.|.|||...:||.:.|:||.||
Zfish   249 --RKHKKDISQNKRALRRLRTACERAKRTLSSSSQASIEIDSLYEGIDFYTSITRARFEELCSDL 311

  Fly   342 WPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESATMGAV 405
            :.....|:|:||..:.:....|:.::|.||.||:|::|:.::.... :||.|::|.||:...||.
Zfish   312 FRGTLDPVEKALKDAKMDKAQIHDIVLVGGSTRIPKIQKLLQDFFNGRELNKSINPDEAVAYGAA 376

  Fly   406 YKAADL---SAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITFN 467
            .:||.|   ::| .|:..::.|..  ||.:..|...|       |..||.......|.|:..||.
Zfish   377 VQAAILMGDTSG-NVQDLLLLDVA--PLSLGIETAGG-------VMTALIKRNTTIPTKQTQTFT 431

  Fly   468 KHTDDFEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKGIKAYFYLDDS 532
            .::|:                             |...:.::.|..:....||..:
Zfish   432 TYSDN-----------------------------QPGVLIQVFEGERAMTKDNNLL--------- 458

  Fly   533 GIFRCTG----------VEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAA 587
            |.|..||          :|..:       |.|.:..|
Zfish   459 GKFELTGIPPAPRGVPQIEVTF-------DIDANGIL---------------------------- 488

  Fly   588 NAGEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGS 652
                       |..|.::...|:.|...:..:...:|.|..::|
Zfish   489 -----------NVSAADKSTGKQNKITITNDKGRLSKEEIERMV--------------------- 521

  Fly   653 AYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLG 717
               |...|..|.:..:.:::   ||.|:||::...::..:::::.....:.|:|::::.:|:...
Zfish   522 ---QEADKYKAEDDLQREKI---SAKNSLESYAFNMKNSVEDDNLKGKISEEDKKRVIEKCNEAV 580

  Fly   718 EWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            .|| |:.:....|.||.:|.:|:|:.|..:::.::
Zfish   581 SWL-ENNQLADKEEYEHQLKELEKVCNPVISKLYQ 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	153/617 (25%)
		HYOU1-like_NBD	23..409	CDD:212672	119/387 (31%)
		TAF4	<572..>627	CDD:296797	5/54 (9%)
hsp70.1	NP_001349288.1	HSP70	5..643	CDD:331774	179/749 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810