DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and XB5934250

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001090720.1	Gene:	XB5934250 / 100036702	XenbaseID:	XB-GENE-5934251	Length:	1026	Species:	Xenopus tropicalis

Alignment Length:	883	Identity:	172/883 - (19%)
Similarity:	283/883 - (32%)	Gaps:	272/883 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 ESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRGEINETAQY 214
            :..|....|.|.|..|..| ..||||..     |::.|:.||.......|       |:.|..:.
Frog    41 DGTQSDSEESVTTPEGLAG-TPREALGK-----NIEELERINKAIEAVKN-------EVEEKQKK 92

  Fly   215 FLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQV---LGVGYDRTLGGLEIQLRLRDYLAQEFN 276
            .|.|..|.:.||               ::.|:...   :..|.|...|.|:..:...  :::...
Frog    93 LLLYKNGIHSTS---------------KVTPLTDSNSNIARGLDMQDGDLKSNVHAN--ISKNGP 140

  Fly   277 ALKKTK----------TDVTTSPRA------LAKLFKEAGRLKN---------------VLSANT 310
            :.::||          ||:...|..      ...:.||.|..|:               .|.|.:
Frog   141 SFERTKKYVIDRRCPATDLEYDPLLNYSAGFFGGILKETGTCKSKRPQHDDDLEVAPCKKLRAAS 205

  Fly   311 EFFAQIENLIEDIDFKLPVTREKLEQLCEDLWP---RATK----PLEEALASSHLSLDVINQVIL 368
            ....:|:....|.|..|.:....||...|...|   .||:    |..:.:..:...:....:
Frog   206 PIRLEIKLQESDDDDILVIDEPPLEADMEKQNPSKCNATEDKYLPFCDKIVENTAQITSATE--- 267

  Fly   369 FGGGTRVPRVQETIKAVIKQEL--------------GKNLNADESATMGAVYKAADLSAGFKVKK 419
             .||  :..:|||.|...|:|.              ..|:|||:........|||......:.:|
Frog   268 -KGG--LISLQETTKHTTKRETETKCINMAETFVSQSGNINADDKKLPSESPKAAYSHLPIQTEK 329

  Fly   420 FVVKDATLFPLQVSFERDPG-DGAAVKQVKRALFALMNPYP--QKKVITFNKHTDDFEFYVNYAD 481
            ...|..|.........:.|. :...:...:..|...::.||  :.|.:.:|..:|.    :|...
Frog   330 NEPKHVTSLECIEDNHKPPQLESIMLVSNQNELCCKLDEYPLMENKNVFWNSGSDG----INGIQ 390

  Fly   482 LDRYSKEEIAALGSLNVTKVQLKQVKE--------LLEKSKKELVDNKGIKAYFYLDDSGIFRCT 538
            ....:.|::.|:..|:....|..|:..        ::..|..:.||  |.:|...|.||
Frog   391 ASLPATEQLFAVTELSAKPEQQCQLGSPTLTANDVIVLDSSSDAVD--GSEAETDLSDS------ 447

  Fly   539 GVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEPSKSEDNEKAK 603
                        ||..|: .|..|.....|..|:..:: .|.|:.||..|.            |:
Frog   448 ------------DDPMEE-CLRIFNEFAEKEATRNSKQ-VDQSQLEEFMNG------------AR 486

  Fly   604 EEDASKEQK---SEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSVAKLAAIN 665
            .:|....||   :..:||.||::.|..:        |.|...||..:|            .|.|.
Frog   487 PDDMVPSQKKRIAHPATKIDTKSSNCIL--------VPYRGPTQQQIP------------HARIL 531

  Fly   666 KAEEQRVRLESAFNALEAHIIEVQQKL--------DEESYAKCATAEEKEKLLAECSTLGEWLYE 722
            ..::|.|::.:|..:.:|.:...|:|:        :......|....|.:.||:..|....:
Frog   532 NVQQQAVQITAAVKSGQAFVASTQKKITGCITPAFNNFGQMVCVNLVEVQPLLSNRSPFTGF--- 593

  Fly   723 DLEDPKAEIYEEKLA--------QLKKLSNV----------FLARHWE----HEERPEAIKALKG 765
                    |...|||        |.:.:..:          |.|....    ||.|...:.:.
Frog   594 --------IQGSKLATSTIMSVPQKRTVQTIPVKSCTRKKPFAASESSSKVPHETRQRYVNSF-- 648

  Fly   766 MIDGAEKFLVTGRNLTKDTNPEKDVFTQVEIDTLDKVITETNAWLKTETAAQKKLAKNADIRLTV 830
                .|:||       |.:...::.|        ||.:.|..|
Frog   649 ----VEEFL-------KVSGTVQEAF--------DKALAEEKA---------------------- 672

  Fly   831 KDITDKMSLLDREVKYLVNKIKIWKPKVK-----PAAEKEKKKEEEVVASG--SGDDTKSEDAEQ 888
              |.|:....:..:...||.:|    |::     |:..|:.|  .:|.|||  ..||.|....:.
Frog   673 --IYDRCGSRNMYLSIAVNSLK----KLRDQRNVPSGSKQPK--TKVSASGLRKQDDKKVSGIDL 729

  Fly   889 Q---QEQATKEEQQEQEPVDEITPTPAEEETKTPHSEL 923
            .   :|....:||.:    |...|.|..|:   |.|.|
Frog   730 YNLFKEYVLSDEQLK----DNGFPQPNPEK---PGSAL 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	108/543 (20%)
		HYOU1-like_NBD	23..409	CDD:212672	62/313 (20%)
		TAF4	<572..>627	CDD:296797	14/57 (25%)
XB5934250	NP_001090720.1	EloA-BP1	625..761	CDD:292495	40/194 (21%)
XB5934250	NP_001090720.1	REX1_like	866..1015	CDD:99848
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900