DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2924 and UBE2Q1

DIOPT Version :9

Sequence 1:	NP_001284819.1	Gene:	CG2924 / 31214	FlyBaseID:	FBgn0023528	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_060052.3	Gene:	UBE2Q1 / 55585	HGNCID:	15698	Length:	422	Species:	Homo sapiens

Alignment Length:	412	Identity:	202/412 - (49%)
Similarity:	274/412 - (66%)	Gaps:	51/412 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LKQEIKTLEKIFPKNHERFQILNSSVDELLCRFI---------------------DKNGKRYDIH 50
            |::|:|.||.||.:.||||:|.::.:|||.|.|:                     ...|....||
Human    41 LRRELKLLESIFHRGHERFRIASACLDELSCEFLLAGAGGAGAGAAPGPHLPPRGSVPGDPVRIH 105

  Fly    51 ANITETYPSSPPVWFAESEETSVTNAVQILSNTNGRDNHVINQVGILLRELCRLHNVPLPPDIDN 115
            .||||:||:.||:|..||::.::...::.|.:....:..::..:..::.:||:|:|:|..||::.
Human   106 CNITESYPAVPPIWSVESDDPNLAAVLERLVDIKKGNTLLLQHLKRIISDLCKLYNLPQHPDVEM 170

  Fly   116 LALPLQTPPPSASPLRCEQRPGGGGAGGGGGPHGNEETDSDQEEIEDPIGESEQESEGDEDLPLE 180
            |..||.....:...:..|..              :||...|.|:::....:.|:.:||.:
Human   171 LDQPLPAEQCTQEDVSSEDE--------------DEEMPEDTEDLDHYEMKEEEPAEGKK----- 216

  Fly   181 MDDVRSTSKKDDMEVEHLATLEKLRQSQRQDYLKGSVSGSVQATDRLMKELRDIYRSDAFKKNMY 245
                   |:.|.:..|:||.|||::::||||||.|:|||||||||||||||||||||.:||...|
Human   217 -------SEDDGIGKENLAILEKIKKNQRQDYLNGAVSGSVQATDRLMKELRDIYRSQSFKGGNY 274

  Fly   246 SIELVNESIYEWNIRLKSVDPDSPLHSDLQMLKEKEGKDSILLNILFKETYPFEPPFVRVVHPII 310
            ::||||:|:|:||::|..||.||.||:|||:||||||.|.||||..||:.:||:|||||||.|::
Human   275 AVELVNDSLYDWNVKLLKVDQDSALHNDLQILKEKEGADFILLNFSFKDNFPFDPPFVRVVSPVL 339

  Fly   311 SGGYVLIGGAICMELLTKQGWSSAYTVEAVIMQIAATLVKGKARIQFGATKALTQGQYSLARAQQ 375
            ||||||.||||||||||||||||||::|:|||||:|||||||||:||||.|:    ||||.||||
Human   340 SGGYVLGGGAICMELLTKQGWSSAYSIESVIMQISATLVKGKARVQFGANKS----QYSLTRAQQ 400

  Fly   376 SFKSLVQIHEKNGWFTPPKEDG 397
            |:||||||||||||:|||||||
Human   401 SYKSLVQIHEKNGWYTPPKEDG 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2924	NP_001284819.1	UBCc	224..>349	CDD:238117	90/124 (73%)
UBE2Q1	NP_060052.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..221		11/72 (15%)
		UBCc	253..409	CDD:412187	116/159 (73%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2522
eggNOG	1	0.900	-	-		E1_KOG0897
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	399	1.000	Inparanoid score	I1946
Isobase	1	0.950	-	0	Normalized mean entropy	S1963
OMA	1	1.010	-	-		QHG49199
OrthoDB	1	1.010	-	-		D1214134at2759
OrthoFinder	1	1.000	-	-		FOG0003048
OrthoInspector	1	1.000	-	-		otm41365
orthoMCL	1	0.900	-	-		OOG6_104870
Panther	1	1.100	-	-	O	PTHR24068
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4130
SonicParanoid	1	1.000	-	-		X2030
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820