DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3071 and SWA1

DIOPT Version :9

Sequence 1:	NP_569993.1	Gene:	CG3071 / 31213	FlyBaseID:	FBgn0023527	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_182320.1	Gene:	SWA1 / 819411	AraportID:	AT2G47990	Length:	530	Species:	Arabidopsis thaliana

Alignment Length:	515	Identity:	158/515 - (30%)
Similarity:	260/515 - (50%)	Gaps:	47/515 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 AQVETPDTVYWDRLAKPELLKEHNT------IDYLDFSPSDPDNFVVTCSVRVQIYNLVTMLVVK 75
            ::.|||::.||..      .|.|:|      :..|.|||..|.:..|..|..|.:::..::...:
plant    30 SESETPESRYWSS------FKNHSTPNLVSSVAALAFSPVHPHSLAVAHSATVSLFSSQSLSSSR 88

  Fly    76 NLSRFQKTAYGATFRQDGRLLAAGDEEGHVKLFDTTSRNILRLFKGHTAPVHRTFF-TADKLQLA 139
            ..| |:.......||.||.|.||.|..|.|::||...|..||..:.|:||.....: ..|||.|.
plant    89 RFS-FRDVVSSVCFRSDGALFAACDLSGVVQVFDIKERMALRTLRSHSAPARFVKYPVQDKLHLV 152

  Fly   140 SFGDDKSVRLWDVANEKVVQTYEDTHTDYVRAGAMHPQAGHMFVSGGYDGKIKLYDTRAETAVQ- 203
            |.|||..|:.||||...|:..... |.||||.|...|....|.|:|.||..:|::|.|..|:..
plant   153 SGGDDGVVKYWDVAGATVISDLLG-HKDYVRCGDCSPVNDSMLVTGSYDHTVKVWDARVHTSNWI 216

  Fly   204 RTLDHGAPVESMLFLPNGSIFVSAGGSQVRVWDLISGCRLLTMMSQHHKTVTCLRLG---SDGRR 265
            ..::||.|||.:::||:|.:..:|||:.|:|||||.|.:::..|..|:||||.||:.   |...|
plant   217 AEINHGLPVEDVVYLPSGGLIATAGGNSVKVWDLIGGGKMVCSMESHNKTVTSLRVARMESAESR 281

  Fly   266 LLSGGLDRHVKIYDVSTYKTVHTLTYPNAVVSMAVA-DGDQAVVAGMVDGLV-----SIRRMMVD 324
            |:|..||.::|::|....|..:::.:|..::|:.:: ||...|:.|. :|:|     .:|.::..
plant   282 LVSVALDGYMKVFDYGRAKVTYSMRFPAPLMSLGLSPDGSTRVIGGS-NGMVFAGKKKVRDVVGG 345

  Fly   325 SKPS-HLKKIRAD----RAR-------KYFVSTKRTNNTQEVDHTIKDHVKGPGLKSYDVHLRQF 377
            .|.| :|..:.:|    |.|       :|| ...::....:.|:.:|:. ||..|..:|..|::|
plant   346 QKKSLNLWSLISDVDESRRRALRPTYFRYF-QRGQSEKPSKDDYLVKEK-KGLKLTRHDKLLKKF 408

  Fly   378 NHKKALDDVMNAQKMQYQPELIVAVITDLLHRGSLGKALTGRHEAALVRFIDFICNHLGEVRFMR 442
            .||:||..|:..:|    |..:|||:.:|:.|..|.|.::...|..|...:.|:..:....|:..
plant   409 RHKEALVSVLEEKK----PANVVAVMEELVARRKLMKCVSNMEEGELGMLLGFLQRYCTVQRYSG 469

  Fly   443 PLMMAASTVLDVFEQRLVAYSQKLMKALQR-LSLAMQEEVRLTAELMRMKGAVDMLIGIS 501
            .||.....||:...:.:...::  .|.|.| |...:.:|:|:...|:.::|.:..|:.|:
plant   470 LLMGLTKKVLETRAEDIKGKNE--FKGLLRNLKREVNQEIRIQQSLLEIQGVIAPLMRIA 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3071	NP_569993.1	WD40	<26..283	CDD:225201	97/267 (36%)
		WD40 repeat	87..121	CDD:293791	15/33 (45%)
		WD40	89..318	CDD:238121	91/239 (38%)
		WD40 repeat	126..162	CDD:293791	14/36 (39%)
		WD40 repeat	170..206	CDD:293791	12/36 (33%)
		WD40 repeat	212..247	CDD:293791	15/34 (44%)
		WD40 repeat	254..288	CDD:293791	13/36 (36%)
		WD40 repeat	295..318	CDD:293791	7/28 (25%)
		UTP15_C	352..494	CDD:286472	38/142 (27%)
SWA1	NP_182320.1	WD40	94..328	CDD:295369	88/234 (38%)
		WD40	<96..>329	CDD:225201	89/234 (38%)
		WD40 repeat	97..133	CDD:293791	15/35 (43%)
		WD40 repeat	138..175	CDD:293791	14/36 (39%)
		WD40 repeat	182..218	CDD:293791	12/35 (34%)
		WD40 repeat	225..261	CDD:293791	15/35 (43%)
		WD40 repeat	267..296	CDD:293791	11/28 (39%)
		UTP15_C	381..520	CDD:286472	38/145 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0310
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6629
Inparanoid	1	1.050	214	1.000	Inparanoid score	I1238
OMA	1	1.010	-	-		QHG54001
OrthoDB	1	1.010	-	-		D621827at2759
OrthoFinder	1	1.000	-	-		FOG0004296
OrthoInspector	1	1.000	-	-		oto4216
orthoMCL	1	0.900	-	-		OOG6_102263
Panther	1	1.100	-	-	LDO	PTHR19924
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.840