DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3071 and TLE3

DIOPT Version :9

Sequence 1:	NP_569993.1	Gene:	CG3071 / 31213	FlyBaseID:	FBgn0023527	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_011520278.1	Gene:	TLE3 / 7090	HGNCID:	11839	Length:	782	Species:	Homo sapiens

Alignment Length:	293	Identity:	59/293 - (20%)
Similarity:	115/293 - (39%)	Gaps:	40/293 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 KTAYGATFRQDGRL---------LAAGDEEGHVKLFDTTSRNILRLFKGHTAPVHRTFFTADKLQ 137
            |.||......||::         ||......|.:..:|.|...:......:.|....:
Human   455 KPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVY------- 512

  Fly   138 LASFGDDKSVRLWDVA---NEKVVQTYEDTHTD-YVRAGAMHPQAGHMFVSGGYDGKIKLYDTRA 198
               .|....|::||::   ::..:...:..:.| |:|:..:.|. |...:.||....:.::|..:
Human   513 ---TGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPD-GRTLIVGGEASTLTIWDLAS 573

  Fly   199 ET-AVQRTLDHGAPV-ESMLFLPNGSI-FVSAGGSQVRVWDLISGCRLLTMMSQHHKTVTCLRLG 260
            .| .::..|...||. .::...|:..: |.......:.|||| ....|:.....|....:|:.:.
Human   574 PTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDL-HNQTLVRQFQGHTDGASCIDIS 637

  Fly   261 SDGRRLLSGGLDRHVKIYDVSTYKTVHTLTYPNAVVSMAVADGDQAVVAGMVDGLVSIRRMMVDS 325
            .||.:|.:||||..|:.:|:...:.:....:.:.:.|:......:.:..||....|.:   :..:
Human   638 HDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEV---LHHT 699

  Fly   326 KPS----HLKK-----IRADRARKYFVSTKRTN 349
            ||.    ||.:     ::.....|:||||.:.|
Human   700 KPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDN 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3071	NP_569993.1	WD40	<26..283	CDD:225201	45/216 (21%)
		WD40 repeat	87..121	CDD:293791	7/42 (17%)
		WD40	89..318	CDD:238121	46/244 (19%)
		WD40 repeat	126..162	CDD:293791	4/38 (11%)
		WD40 repeat	170..206	CDD:293791	7/36 (19%)
		WD40 repeat	212..247	CDD:293791	7/36 (19%)
		WD40 repeat	254..288	CDD:293791	10/33 (30%)
		WD40 repeat	295..318	CDD:293791	4/22 (18%)
		UTP15_C	352..494	CDD:286472
TLE3	XP_011520278.1	TLE_N	9..143	CDD:397828
		WD40	494..779	CDD:238121	50/254 (20%)
		WD40 repeat	499..538	CDD:293791	5/48 (10%)
		WD40 repeat	546..584	CDD:293791	8/38 (21%)
		WD40 repeat	589..625	CDD:293791	7/36 (19%)
		WD40 repeat	632..667	CDD:293791	10/34 (29%)
		WD40 repeat	672..705	CDD:293791	6/35 (17%)
		WD40 repeat	713..747	CDD:293791	6/20 (30%)
		WD40 repeat	754..778	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910