DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3078 and CG2121

DIOPT Version :9

Sequence 1:	NP_001356930.1	Gene:	CG3078 / 31211	FlyBaseID:	FBgn0023524	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_001137618.1	Gene:	CG2121 / 35814	FlyBaseID:	FBgn0033289	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	123/542 - (22%)
Similarity:	208/542 - (38%)	Gaps:	99/542 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 NNRNCRHKVPAHVRQKVWRQFSCLSLA--------HGLMNCVLLPVMALQGS-NAVWHHREEWL- 286
            |..|.||..||. |..:.:....:.||        ||..|        ||.| ||     ::.|
  Fly    62 NKVNQRHYEPAE-RFIITKNVVVIGLAFMIHFTAFHGTSN--------LQSSVNA-----DKALG 112

  Fly   287 --PLGPEVGSLLLSALFLVAAGMSLPSIRL---MKRYGYGPLIVANYMTVLLFLLSHLYASIYTL 346
              .|....|||:||.:||....:.....||   :..:.|.|.|.|.:           |....||
  Fly   113 TTTLAVIYGSLILSNIFLPMTVIRWFGCRLTMALALFAYMPYIAAQF-----------YPRFETL 166

  Fly   347 LPAYLLLGMTLSGSAGSKAALIVHFGGKLSCS-CD--SQQSQAAVDVLHEEHKMFCNRDQKVRRL 408
            :||.|::|..               ||.|.|| |.  |..|:|...|...:.:    :|....:.
  Fly   167 IPAALMVGFG---------------GGPLWCSKCTYLSTVSEALTQVRGNKSR----KDVNTVKF 212

  Fly   409 ARWFRVSQDLGLIGGALLASILLACSDGNFTGDCSGLVYYGNESWPPQLRDFYNRNEHGDRICGA 473
            ...|.:...:..:.|.|::|.:|..|       ........|:|:..:::....||...: :|||
  Fly   213 FGLFFIFYQMAQVWGNLISSSVLTLS-------APAAQSAANDSFELEVQRELERNRVAE-LCGA 269

  Fly   474 DMCPLRVQSILEAGWANGSSIPSSIYAGFIESEPRVAGQSLLWLYVLFSMVSLTLSLLIVVDKVQ 538
            ..||      .....||.:.:|           |......||....|..|.:..:.::..|..::
  Fly   270 RFCP------GVGAEANPNLVP-----------PAPEQIQLLNSIFLTCMAAAVVMMIFGVSSLK 317

  Fly   539 AIGSSRPERSRDVS----ITDTL--------LFAGPLAYFVGTEQAYMMGDFLRAFVTCSLGIGM 591
            ..|..|.:....:|    :|.|:        :...|:..|:|.|:|::..||.|:||.|..||..
  Fly   318 RYGVKRGDTGDGMSGLKLLTVTINLLRKRRQILMLPITMFIGLEEAFLAVDFTRSFVACGWGISR 382

  Fly   592 IAGALIGMGLMQLIVSCTLSMLLRHVKRIVVILAGFFFHSCLLLALSSWKPSSDDSALFYVIAAS 656
            |..|:|..|:...:.:.....|:..:.|:.:.......:.|||..:.:|:....|...:...||.
  Fly   383 IGFAMICFGVANAVAAGIAGALVERIGRVTLAALCAVVNLCLLTYMYTWEAREGDYMSYCTFAAV 447

  Fly   657 WGACNGMWETLLLSLVTLNHSSHVTEVQAPLLALRFLGLGLTFAGHGFLCESMKIIALVVLLVIS 721
            ||.|:|:|..::.:...:...:|:....:........|..:.:.....||.|.|::.|::.:::.
  Fly   448 WGICDGVWLVVVNAFYGILFPNHLIAAYSNFRLWESTGSVIGYVISSQLCTSTKLVILIIFILVG 512

  Fly   722 VPPYATLEIRLEAQRKATLVSL 743
            ...|..:|.|...::|...|.|
  Fly   513 CVGYGLIEYRFWQKQKNLEVML 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3078	NP_001356930.1	bZIP	<11..>43	CDD:354818
CG3078	NP_001356930.1	MFS	<496..731	CDD:355786	51/246 (21%)
CG2121	NP_001137618.1	MFS	84..>189	CDD:304372	38/143 (27%)
CG2121	NP_001137618.1	MFS_1	<296..476	CDD:284993	40/179 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445365
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3097
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4703
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1145833at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19444
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.800