DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3091 and Sec14l1

DIOPT Version :9

Sequence 1:	NP_001284816.1	Gene:	CG3091 / 31210	FlyBaseID:	FBgn0029608	Length:	303	Species:	Drosophila melanogaster
Sequence 2:	NP_083053.2	Gene:	Sec14l1 / 74136	MGIID:	1921386	Length:	719	Species:	Mus musculus

Alignment Length:	353	Identity:	63/353 - (17%)
Similarity:	120/353 - (33%)	Gaps:	108/353 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDKDTGDKDSAPETSASPATGWSDKLTD---------------------LVAWF-EANPNLPEKI 43
            |:..:|:..|:|.|::.|..|..|...|                     |..|. |.:.....|.
Mouse   213 MEGLSGENLSSPGTASEPVVGTPDDKLDADYIKRYLGDLTPLQESCLIRLRQWLQETHKGKIPKD 277

  Fly    44 EPIVMLRFLKCTAFDVERTKALA----------ELNYCMRN-KSPHLFMDRNMEDEMTAEGLRVS 97
            |.|  ||||:...|::::.:.:.          :::|.:.. ..|.:.:|      ..|.|....
Mouse   278 EHI--LRFLRARDFNIDKAREIMCQSLTWRKQHQVDYILDTWTPPQVLLD------YYAGGWHHH 334

  Fly    98 DLLILPGVTPQGNKLIFFRMADLDPR----------------------TRNSVEETKIFVMMSDA 140
            |        ..|..|...|:..:|.:                      .|...|.||:|
Mouse   335 D--------KDGRPLYVLRLGQMDTKGLVRALGEEALLRYVLSINEEGLRRCEENTKVF------ 385

  Fly   141 RFTKPDVERETGSGADYVLDEADIAEGDVQIVDIGGYTLRHLAYVSIFVLRVYMKFLQEAYPSRL 205
                   .|...|.              ..:||:.|..:|||....:..|...::.::..||..|
Mouse   386 -------GRPISSW--------------TCLVDLEGLNMRHLWRPGVKALLRIIEVVEANYPETL 429

  Fly   206 QAMHVINCPTYLDKLISMMSPFLREEVRNMIRYHT----EGMDSLYKEVPRDMLPNEYGGKAGTV 266
            ..:.::..|.....|.:::|||:.:..|.....:.    :|...|...:.::::|:...|:.  :
Mouse   430 GRLLILRAPRVFPVLWTLVSPFIDDNTRRKFLIYAGNDYQGPGGLLDYIDKEIIPDFLSGEC--M 492

  Fly   267 AELKAKGI--QSIRDNAAYLSDE--RYW 290
            .::...|:  :|:...|..|.:|  :.|
Mouse   493 CDVPEGGLVPKSLYRTAEELENEDLKLW 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3091	NP_001284816.1	SEC14	101..262	CDD:238099	30/186 (16%)
Sec14l1	NP_083053.2	Required for interaction and inhibitory function toward DDX58. /evidence=ECO:0000250\|UniProtKB:Q92503	1..510		59/341 (17%)
		PRELI	17..173	CDD:282550
		CRAL_TRIO_N	256..301	CDD:215024	11/46 (24%)
		CRAL_TRIO	326..490	CDD:279044	33/198 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900