DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3091 and TTPA

DIOPT Version :9

Sequence 1:	NP_001284816.1	Gene:	CG3091 / 31210	FlyBaseID:	FBgn0029608	Length:	303	Species:	Drosophila melanogaster
Sequence 2:	NP_000361.1	Gene:	TTPA / 7274	HGNCID:	12404	Length:	278	Species:	Homo sapiens

Alignment Length:	257	Identity:	62/257 - (24%)
Similarity:	114/257 - (44%)	Gaps:	34/257 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PNLPEKIEPIVMLRFLKCTAFDVERTKALAELNYCMRNKSPHLFMDRNMEDEMTAEGLRVSDLL- 100
            |..|..:....:||||:...||::....|.:..|..|.:.|.:..|.:...        :..||
Human    41 PLAPLPLTDSFLLRFLRARDFDLDLAWRLLKNYYKWRAECPEISADLHPRS--------IIGLLK 97

  Fly   101 -----ILPGVTPQGNKLIFFRMADLDPRTRNSVEETKIFVMMSDARFTKPDVERETGSGADYVLD 160
                 :|....|.|:|::.:|:|..||:.                 ||..||.|.:...::.::.
Human    98 AGYHGVLRSRDPTGSKVLIYRIAHWDPKV-----------------FTAYDVFRVSLITSELIVQ 145

  Fly   161 EADIAEGDVQ-IVDIGGYTLRHLAYVSIFVLRVYMKFLQEAYPSRLQAMHVINCPTYLDKLISMM 224
            |.:.....:: |.|:.|:...|...::..|.:.....|.:::|.:::.:|:||.|.....:.||:
Human   146 EVETQRNGIKAIFDLEGWQFSHAFQITPSVAKKIAAVLTDSFPLKVRGIHLINEPVIFHAVFSMI 210

  Fly   225 SPFLREEVRNMIRYHTEG-MDSLYKEVPRDMLPNEYGGKAGTVAELKAKGIQSIRDNAAYLS 285
            .|||.|:::..|..|... ..||.:..| |:||.||||:..::.::..:....|..:..|||
Human   211 KPFLTEKIKERIHMHGNNYKQSLLQHFP-DILPLEYGGEEFSMEDICQEWTNFIMKSEDYLS 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3091	NP_001284816.1	SEC14	101..262	CDD:238099	42/162 (26%)
TTPA	NP_000361.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		CRAL_TRIO_N	<40..73	CDD:215024	9/31 (29%)
		CRAL_TRIO	99..248	CDD:395525	42/166 (25%)
		Phosphatidylinositol 3,4-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:Q8BWP5	190..192		0/1 (0%)
		Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:Q8BWP5	208..211		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1053004at2759
OrthoFinder	1	1.000	-	-		FOG0000233
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10174
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920