DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3191 and SEC14L1

DIOPT Version :9

Sequence 1:	NP_001245486.2	Gene:	CG3191 / 31209	FlyBaseID:	FBgn0023525	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	NP_001034662.3	Gene:	SEC14L1 / 6397	HGNCID:	10698	Length:	719	Species:	Homo sapiens

Alignment Length:	272	Identity:	52/272 - (19%)
Similarity:	98/272 - (36%)	Gaps:	79/272 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QERDLKELLEWFRQ--NDKLPKEIDPLLLRRFYQCMFGDVEETRKLIEVNYALRNRHPHLFIKRD 96
            ||..|..|.:|.::  ..|:||:...|   ||.:....::::.|:::..:...|.:|
Human   255 QESCLIRLRQWLQETHKGKIPKDEHIL---RFLRARDFNIDKAREIMCQSLTWRKQH-------- 308

  Fly    97 PLDADSKRTFDYADILPLPGLTPDKCKVSLYCFREFEASKMHHTEDTRAFFMVSDCRFVTPDDLA 161
                    ..||.    |...||.:.....|.     ....||.:|.|..:::.         |.
Human   309 --------QVDYI----LETWTPPQVLQDYYA-----GGWHHHDKDGRPLYVLR---------LG 347

  Fly   162 KPD----------------VLS---------EGEVQIF-----------DMKGTTMRHISRLTIS 190
            :.|                |||         |...::|           |::|..|||:.|..:.
Human   348 QMDTKGLVRALGEEALLRYVLSINEEGLRRCEENTKVFGRPISSWTCLVDLEGLNMRHLWRPGVK 412

  Fly   191 TLRAYIKFLQLAFPVRLRAIHMINCPTYLDRIVSVVKPFISDEVFKLIRFHT----QSINTLYEF 251
            .|...|:.::..:|..|..:.::..|.....:.::|.|||.|...:....:.    |....|.::
Human   413 ALLRIIEVVEANYPETLGRLLILRAPRVFPVLWTLVSPFIDDNTRRKFLIYAGNDYQGPGGLLDY 477

  Fly   252 VPREMLPEEYGG 263
            :.:|::|:...|
Human   478 IDKEIIPDFLSG 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3191	NP_001245486.2	SEC14	114..263	CDD:238099	35/188 (19%)
SEC14L1	NP_001034662.3	PRELI	17..173	CDD:368069
		CRAL_TRIO_N	256..301	CDD:215024	11/47 (23%)
		CRAL_TRIO	326..490	CDD:366224	33/178 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810