DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3191 and CLVS2

DIOPT Version :9

Sequence 1:	NP_001245486.2	Gene:	CG3191 / 31209	FlyBaseID:	FBgn0023525	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	NP_001010852.2	Gene:	CLVS2 / 134829	HGNCID:	23046	Length:	327	Species:	Homo sapiens

Alignment Length:	257	Identity:	64/257 - (24%)
Similarity:	115/257 - (44%)	Gaps:	32/257 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 QLQREQDSDTSEQAVRKQERDL---KELLEWFRQNDKLPKEIDPLLLRRFYQCMFGDVEETRKLI 78
            :|:..::.||..|.: ::.||:   :..:.:.|.:|......  |..|:|:..      |..:|:
Human    17 RLELNENPDTLHQDI-QEVRDMVITRPDIGFLRTDDAFILRF--LRARKFHHF------EAFRLL 72

  Fly    79 EVNYALRNRHPHLFIKRDPLDADSKRTFDYADILP--LPGLTPDKCKVSLYCFREFEASKMHHTE 141
            ...:..|.::..:|......|...|:..  .|..|  |..|.....|:.:.....::.|:....:
Human    73 AQYFEYRQQNLDMFKSFKATDPGIKQAL--KDGFPGGLANLDHYGRKILVLFAANWDQSRYTLVD 135

  Fly   142 DTRAFF-----MVSDCRFVTPDDLAKPDVLSEGEVQIFDMKGTTMRHISRLTISTLRAYIKFLQL 201
            ..||..     |:.|           |::...|.|.|.|....|.:..|:||.|.||..|:.||.
Human   136 ILRAILLSLEAMIED-----------PELQVNGFVLIIDWSNFTFKQASKLTPSMLRLAIEGLQD 189

  Fly   202 AFPVRLRAIHMINCPTYLDRIVSVVKPFISDEVFKLIRFHTQSINTLYEFVPREMLPEEYGG 263
            :||.|...||.:|.|.|:..:.:|::||:.::..|.|..|..::|:|::.:..|:||.|:||
Human   190 SFPARFGGIHFVNQPWYIHALYTVIRPFLKEKTRKRIFLHGNNLNSLHQLIHPEILPSEFGG 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3191	NP_001245486.2	SEC14	114..263	CDD:238099	43/153 (28%)
CLVS2	NP_001010852.2	CRAL_TRIO_N	29..75	CDD:215024	10/54 (19%)
		SEC14	106..251	CDD:238099	43/155 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145895
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750