DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crn and CLF1

DIOPT Version :9

Sequence 1:	NP_477118.1	Gene:	crn / 31208	FlyBaseID:	FBgn0000377	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_013218.1	Gene:	CLF1 / 850808	SGDID:	S000004107	Length:	687	Species:	Saccharomyces cerevisiae

Alignment Length:	696	Identity:	260/696 - (37%)
Similarity:	409/696 - (58%)	Gaps:	65/696 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EVQITAEQLLREAKER--------DLEILPPPPKQKISDPAELADYQQRKRKTFEDNLRKNRMVV 76
            :..::|||:||:..::        :::||         |..||.:||:|||..:|..|::||:.:
Yeast    10 DTHVSAEQILRDVYKKGQKARGSTNIDIL---------DLEELREYQRRKRTEYEGYLKRNRLDM 65

  Fly    77 SHWIKYAQWEEQQQEIQRARSIWERALDNEHRNVTLWLKYAEMEMKNKQVNHARNLWDRAVTIMP 141
            ..||:|||:|.:|.:::|||||:||||..:...:.||::|.:.|:|.|.:||||||.:||::.:|
Yeast    66 GQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLP 130

  Fly   142 RVNQFWYKYTYMEEMLENVAGARQVFERWMEWQPEEQAWQTYVNFELRYKEIDRAREIYERFVYV 206
            ||::.||||..:||.|.||...|.::.:|...:|...||.::|:||:|.|..:..||||.::|..
Yeast   131 RVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNGVREIYSKYVMA 195

  Fly   207 HPDVKNWIKFARFEESHGFIHGSRRVFERAVEFFGD--------DYIEERLFIAFARFEEGQKEH 263
            ||.::.|:|:.|||..||....:|.|:..|::...:        |....:|..:||.:|..|:|:
Yeast   196 HPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEY 260

  Fly   264 DRARIIYKYALDHLPKDRTQELFKA-YTKHEKKYGDRAGIEDVIVSKRKYQYEQEVAANPTNYDA 327
            :|:..:|:.|::..|   :.:|.|| ....||::||...||:.|..|||.:||..::.|..:||.
Yeast   261 ERSSALYQIAIEKWP---SNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDT 322

  Fly   328 WFDYLRLIEAEGDRDQIRETYERAISNVPPAN-EKNF-WRRYIYLWINYALYEELEAEDAERTRQ 390
            |:.||.|| :|....||.:|:|:||.:..|.. .||. |:||||||:.|..|.|||.|::....:
Yeast   323 WWLYLDLI-SESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEE 386

  Fly   391 IYKTCL-ELIPHKQFTFSKLWLLYAQFEIRCKELQRARKALGLAIGMCPRDKLFRGYIDLEIQLR 454
            :::..: ::||||.|||||:||:||:|.||..::.:|||.||.|||:||:.|.|:|||:||::|:
Yeast   387 LFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLK 451

  Fly   455 EFERCRMLYEKFLEFGPENCVTWMKFAELENLLGDTDRARAIFELAVQQP----RLDMPELLWKA 515
            ||:|.|.:||||:||.|.:...|.::.|||..|||.||.|.|:.:|:.:.    ..:...:|.:.
Yeast   452 EFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQK 516

  Fly   516 YIDFEVALGETELARQLYERLLERTQH-VKVWMSFAKFEMG------------LSHGDSGPDAEL 567
            ||.||....|.|.||:||.|.||..|: .:.|:.||.::..            |...:...|.|.
Yeast   517 YITFETESQEFEKARKLYRRYLELNQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEF 581

  Fly   568 -----NVQLARRIYERANEMLRQLGDKESRVLLLEAWRDFERDASDSQEMQKVMDKMPRRIKKRQ 627
                 |...||:::|.|....::..||:.|:.:|||.:|:|.......:.:.|..:.|:.||
Yeast   582 EITDENKLEARKVFEEAIVFFKEKDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKVIK--- 643

  Fly   628 KIVSDNGVEEGWEEVFDYIFP---EDEMARPNLKLLAAAKMWKTQK 670
            |:...||||   ||..|||||   :|:..:|: |.|..||.||.::
Yeast   644 KVRLQNGVE---EEFVDYIFPDDIDDDKPKPS-KFLELAKKWKQEQ 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crn	NP_477118.1	HAT	94..122	CDD:214642	13/27 (48%)
		TPR repeat	109..139	CDD:276809	14/29 (48%)
		TPR repeat	144..172	CDD:276809	11/27 (41%)
		RNA14	<180..539	CDD:227438	150/374 (40%)
		HAT	191..222	CDD:111114	13/30 (43%)
		TPR repeat	473..503	CDD:276809	12/29 (41%)
		TPR repeat	508..538	CDD:276809	12/29 (41%)
CLF1	NP_013218.1	U3_assoc_6	<64..>157	CDD:421384	43/92 (47%)
		TPR repeat	68..93	CDD:276809	15/24 (63%)
		HAT	80..111	CDD:214642	13/30 (43%)
		TPR repeat	98..128	CDD:276809	14/29 (48%)
		TPR repeat	133..158	CDD:276809	10/24 (42%)
		HAT	186..211	CDD:111114	12/24 (50%)
		TPR repeat	404..432	CDD:276809	15/27 (56%)
		TPR repeat	437..466	CDD:276809	16/28 (57%)
		HAT	451..483	CDD:214642	15/31 (48%)
		TPR repeat	471..499	CDD:276809	12/27 (44%)
		TPR repeat	511..539	CDD:276809	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341608
Domainoid	1	1.000	280	1.000	Domainoid score	I257
eggNOG	1	0.900	-	-		E1_KOG1915
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	455	1.000	Inparanoid score	I245
Isobase	1	0.950	-	0	Normalized mean entropy	S716
OMA	1	1.010	-	-		QHG54523
OrthoFinder	1	1.000	-	-		FOG0003119
OrthoInspector	1	1.000	-	-		oto99539
orthoMCL	1	0.900	-	-		OOG6_101977
Panther	1	1.100	-	-	LDO	PTHR11246
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R208
SonicParanoid	1	1.000	-	-		X2089
TreeFam	1	0.960	-	-
	15	14.740