DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crn and CRNKL1

DIOPT Version :9

Sequence 1:	NP_477118.1	Gene:	crn / 31208	FlyBaseID:	FBgn0000377	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_057736.4	Gene:	CRNKL1 / 51340	HGNCID:	15762	Length:	848	Species:	Homo sapiens

Alignment Length:	693	Identity:	468/693 - (67%)
Similarity:	572/693 - (82%)	Gaps:	15/693 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QKMPKVAKVKNKAPAEVQITAEQLLREAKERDLEILPPPPKQKISDPAELADYQQRKRKTFEDNL 69
            |::||||||||||||||||||||||||||||:||:|||||:|||:|..||.||:.|||||||||:
Human   171 QRIPKVAKVKNKAPAEVQITAEQLLREAKERELELLPPPPQQKITDEEELNDYKLRKRKTFEDNI 235

  Fly    70 RKNRMVVSHWIKYAQWEEQQQEIQRARSIWERALDNEHRNVTLWLKYAEMEMKNKQVNHARNLWD 134
            ||||.|:|:|||||||||..:||||||||:|||||.::||:|||||||||||||:|||||||:||
Human   236 RKNRTVISNWIKYAQWEESLKEIQRARSIYERALDVDYRNITLWLKYAEMEMKNRQVNHARNIWD 300

  Fly   135 RAVTIMPRVNQFWYKYTYMEEMLENVAGARQVFERWMEWQPEEQAWQTYVNFELRYKEIDRAREI 199
            ||:|.:|||||||||||||||||.||||||||||||||||||||||.:|:||||||||:||||.|
Human   301 RAITTLPRVNQFWYKYTYMEEMLGNVAGARQVFERWMEWQPEEQAWHSYINFELRYKEVDRARTI 365

  Fly   200 YERFVYVHPDVKNWIKFARFEESHGFIHGSRRVFERAVEFFGDDYIEERLFIAFARFEEGQKEHD 264
            |||||.||||||||||:|||||.|.:...:|:|:|||||||||::::|.|::|||:|||.|||.:
Human   366 YERFVLVHPDVKNWIKYARFEEKHAYFAHARKVYERAVEFFGDEHMDEHLYVAFAKFEENQKEFE 430

  Fly   265 RARIIYKYALDHLPKDRTQELFKAYTKHEKKYGDRAGIEDVIVSKRKYQYEQEVAANPTNYDAWF 329
            |.|:|||||||.:.|...|||||.||..|||:|||.||||:|||||::|||:||.|||.||||||
Human   431 RVRVIYKYALDRISKQDAQELFKNYTIFEKKFGDRRGIEDIIVSKRRFQYEEEVKANPHNYDAWF 495

  Fly   330 DYLRLIEAEGDRDQIRETYERAISNVPPANEKNFWRRYIYLWINYALYEELEAEDAERTRQIYKT 394
            |||||:|::.:.:.:||.|||||:||||..||..|:|||||||||||||||||:|.|||||:|:.
Human   496 DYLRLVESDAEAEAVREVYERAIANVPPIQEKRHWKRYIYLWINYALYEELEAKDPERTRQVYQA 560

  Fly   395 CLELIPHKQFTFSKLWLLYAQFEIRCKELQRARKALGLAIGMCPRDKLFRGYIDLEIQLREFERC 459
            .|||||||:|||:|:|:||||||||.|.|..||:|||.:||.||::|||:.||:||:|||||:||
Human   561 SLELIPHKKFTFAKMWILYAQFEIRQKNLSLARRALGTSIGKCPKNKLFKVYIELELQLREFDRC 625

  Fly   460 RMLYEKFLEFGPENCVTWMKFAELENLLGDTDRARAIFELAVQQPRLDMPELLWKAYIDFEVALG 524
            |.|||||||||||||.:|:||||||.:|||.||||||:|||:.||||||||:|||:|||||:...
Human   626 RKLYEKFLEFGPENCTSWIKFAELETILGDIDRARAIYELAISQPRLDMPEVLWKSYIDFEIEQE 690

  Fly   525 ETELARQLYERLLERTQHVKVWMSFAKFEMGLSHGDSGPDAELNVQLARRIYERANEMLRQLGDK 589
            |||..|.||.|||:||||||||:|||:||  ||.|..|     ::...|:|||.||:.:|...:|
Human   691 ETERTRNLYRRLLQRTQHVKVWISFAQFE--LSSGKEG-----SLTKCRQIYEEANKTMRNCEEK 748

  Fly   590 ESRVLLLEAWRDFERDASDSQEMQKVMDKMPRRIKKRQKIVSDNGVEEGWEEVFDYIFPEDEMAR 654
            |.|::|||:||.||.:...:.:.::|...||.::|||:|:.:|:|.:.||||.||||||||...:
Human   749 EERLMLLESWRSFEEEFGTASDKERVDKLMPEKVKKRRKVQTDDGSDAGWEEYFDYIFPEDAANQ 813

  Fly   655 PNLKLLAAAKMWKTQKDNTVDDPPATAIASEPEPAADAAPADT 697
            |||||||.||:||.|:....|        :|..|..|...:::
Human   814 PNLKLLAMAKLWKKQQQEKED--------AEHHPDEDVDESES 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crn	NP_477118.1	HAT	94..122	CDD:214642	22/27 (81%)
		TPR repeat	109..139	CDD:276809	25/29 (86%)
		TPR repeat	144..172	CDD:276809	26/27 (96%)
		RNA14	<180..539	CDD:227438	251/358 (70%)
		HAT	191..222	CDD:111114	26/30 (87%)
		TPR repeat	473..503	CDD:276809	21/29 (72%)
		TPR repeat	508..538	CDD:276809	19/29 (66%)
CRNKL1	NP_057736.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..106
		U3_assoc_6	219..>356	CDD:421384	112/136 (82%)
		HAT 1	222..254		25/31 (81%)
		TPR repeat	245..270	CDD:276809	20/24 (83%)
		HAT 2	256..288		25/31 (81%)
		TPR repeat	275..305	CDD:276809	25/29 (86%)
		HAT 3	290..322		26/31 (84%)
		TPR repeat	310..338	CDD:276809	26/27 (96%)
		HAT 4	324..355		26/30 (87%)
		HAT	357..388	CDD:111114	26/30 (87%)
		HAT 5	357..388		26/30 (87%)
		HAT 6	390..425		18/34 (53%)
		Suf	393..>483	CDD:399092	57/89 (64%)
		Mediates interaction with HSP90. /evidence=ECO:0000250\|UniProtKB:P63154	411..628		147/216 (68%)
		RNA14	479..>688	CDD:227438	152/208 (73%)
		TPR repeat	573..601	CDD:276809	17/27 (63%)
		TPR repeat	606..635	CDD:276809	21/28 (75%)
		HAT 12	620..652		26/31 (84%)
		TPR repeat	640..668	CDD:276809	20/27 (74%)
		HAT 13	654..688		27/33 (82%)
		HAT 14	690..721		22/32 (69%)
		HAT 15	726..767		18/45 (40%)
		HAT 16	769..807		17/37 (46%)
		HAT 17	809..834		13/24 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	827..848		5/28 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141707
Domainoid	1	1.000	610	1.000	Domainoid score	I190
eggNOG	1	0.900	-	-		E1_KOG1915
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6462
Inparanoid	1	1.050	998	1.000	Inparanoid score	I300
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54523
OrthoDB	1	1.010	-	-		D147873at33208
OrthoFinder	1	1.000	-	-		FOG0003119
OrthoInspector	1	1.000	-	-		oto89787
orthoMCL	1	0.900	-	-		OOG6_101977
Panther	1	1.100	-	-	LDO	PTHR11246
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R208
SonicParanoid	1	1.000	-	-		X2089
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800