DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crn and fand

DIOPT Version :9

Sequence 1:	NP_477118.1	Gene:	crn / 31208	FlyBaseID:	FBgn0000377	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_610891.1	Gene:	fand / 36514	FlyBaseID:	FBgn0033859	Length:	883	Species:	Drosophila melanogaster

Alignment Length:	886	Identity:	169/886 - (19%)
Similarity:	291/886 - (32%)	Gaps:	330/886 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 FEDNLRKNRMVVSHWIKYAQ-------------WEEQQQEIQRARSIW----------------- 99
            :|:.:.:|...|.||::|..             :|...:|:..:..||
  Fly    22 YEEEILRNAYSVKHWLRYIDHKAKAPNNGVNMVYERALKELPGSYKIWHNYLRTRRKQVRGKIPT 86

  Fly   100 -----------ERALDNEHRNVTLWLKYAEMEMKNKQVNHARNLWDRAVTIMP--RVNQFWYKYT 151
                       ||||...|:...:|:.|........::...|:::|||:..:|  :..:.|..|.
  Fly    87 DPMYEEVNSAFERALVFMHKMPRIWMDYGAFMTSQCKITRTRHVFDRALRALPITQHGRIWPLYL 151

  Fly   152 YMEEMLENVAGARQVFERWMEWQPEE--------------------------------------- 177
            ......|....|.:|:.|:::..||:
  Fly   152 QFVRRFEMPETALRVYRRYLKLFPEDTEEYVDYLQEADRLDEAAQQLAHIVDNEHFVSKHGKSNH 216

  Fly   178 --------------------------------------QAWQTYVNFELRYKEIDRAREIYE--- 201
                                                  ..|.:..::.:|....||||:|||
  Fly   217 QLWNELCDLISKNPHKVHSLNVDAIIRGGLRRYTDQLGHLWNSLADYYVRSGLFDRARDIYEEAI 281

  Fly   202 --------------------------------------------------RFVY----------- 205
                                                              ||.|
  Fly   282 QTVTTVRDFTQVFDEYAQFEELSLNRRMEQVAANEAATEEDDIDVELRLSRFEYLMERRLLLLNS 346

  Fly   206 ---------VHPDVKN----------------------------------WIKFARFEESHGFIH 227
                     ||...|.                                  |::||:|.|::|.:.
  Fly   347 VLLRQNPHNVHEWHKRVTLYEDKPAEIISTYTEAVQTVQPKQAVGKLHTLWVEFAKFYEANGQVE 411

  Fly   228 GSRRVFERAVEFFGDDYIE----ERLFIAFARFEEGQKEHDRARIIYKYALDHLPK--------- 279
            .:|.||||..|.   :|::    ..::..:|..|..|::.:.|..:.:.| ..:||
  Fly   412 DARVVFERGTEV---EYVKVEDLAAVWCEWAEMELRQQQFEAALKLMQRA-TAMPKRKIAYYDDT 472

  Fly   280 -------DRTQELFKAYTKHEKKYGDRAGIEDVIVSKRKYQYEQEVAANPTNYDAWFDYLRLIEA 337
                   .|:.:::..|...|:.:|        .....|..||:.:...........:|...:|.
  Fly   473 ETVQARLHRSLKVWSMYADLEESFG--------TFKTCKAVYERIIDLKICTPQIIINYGMFLEE 529

  Fly   338 EGDRDQIRETYERAISNVPPANEKNFWRRYIYLWINYALYEELEAEDAERTRQIYKTCLELIP-- 400
            ....::....||:.||.....|..:.|..|:..::     |.......||.|.:::.||:..|
  Fly   530 HNYFEEAYRAYEKGISLFKWPNVYDIWNSYLTKFL-----ERYGGTKLERARDLFEQCLDQCPPE 589

  Fly   401 HKQFTFSKLWLLYAQFEIRCKELQRARKALGL---AIGMCPRDKLFRGY---IDLEIQLREFERC 459
            |.::    .:||||:.|   :|...||.|:.:   |......|::|..|   |....::....|.
  Fly   590 HAKY----FYLLYAKLE---EEHGLARHAMSVYDRATSAVKEDEMFDMYNIFIKKAAEIYGLPRT 647

  Fly   460 RMLYEKFLEFGPEN-----CVTWMKFAELENLLGDTDRARAIFELAVQ--QPRLDMPELLWKAYI 517
            |.:|||.:|..||.     ||   ||||||..||:.||||||:....|  .||:...  .|:.:.
  Fly   648 REIYEKAIESLPEQNMRHMCV---KFAELETKLGEVDRARAIYAHCSQVCDPRITAD--FWQTWK 707

  Fly   518 DFEVALGETELARQL--YERLLERTQHVKVWMSFAKFEMGLSHG-------DSGPDAELNVQLAR 573
            :|||..|..:..|::  .:|.::.|.:.:|.|..|:| :..::|       .:||||
  Fly   708 EFEVRHGNEDTMREMLRIKRSVQATYNTQVNMMAAQF-LSTNNGAAADAGAGAGPDA-------- 763

  Fly   574 RIYERANEMLRQLGDKESRVLLLEAWRDFERDASD-----SQEMQKVMDKMPRRIKKRQKIVSDN 633
                     :|.|.:|..:.......:..|:.||:     .:......||....:...:..:.|:
  Fly   764 ---------MRLLEEKARQAAAESKQKPIEKAASNIMFVRGETQGGAKDKKDTVVNPDEIDIGDS 819

  Fly   634 GVEEGWEEVFDYIFPEDEMARPNLKLLAAAKMWKTQKDNTV 674
            . |:..||..|   .|:||...|   .|:|.:.||.::..|
  Fly   820 D-EDDEEEDDD---EENEMTNEN---QASAAVTKTDEEGLV 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crn	NP_477118.1	HAT	94..122	CDD:214642	9/55 (16%)
		TPR repeat	109..139	CDD:276809	6/29 (21%)
		TPR repeat	144..172	CDD:276809	6/27 (22%)
		RNA14	<180..539	CDD:227438	107/502 (21%)
		HAT	191..222	CDD:111114	17/137 (12%)
		TPR repeat	473..503	CDD:276809	17/36 (47%)
		TPR repeat	508..538	CDD:276809	7/31 (23%)
fand	NP_610891.1	TPR repeat	432..460	CDD:276809	5/28 (18%)
		PilF	443..>617	CDD:225605	38/194 (20%)
		TPR repeat	482..512	CDD:276809	6/37 (16%)
		TPR repeat	517..545	CDD:276809	4/27 (15%)
		TPR repeat	553..584	CDD:276809	7/35 (20%)
		TPR repeat	591..618	CDD:276809	9/33 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446192
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11246
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940