DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crn and cwf4

DIOPT Version :9

Sequence 1:	NP_477118.1	Gene:	crn / 31208	FlyBaseID:	FBgn0000377	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_596573.1	Gene:	cwf4 / 2540328	PomBaseID:	SPBC31F10.11c	Length:	674	Species:	Schizosaccharomyces pombe

Alignment Length:	671	Identity:	341/671 - (50%)
Similarity:	471/671 - (70%)	Gaps:	24/671 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KVKNKAPAEVQITAEQLLREAKERDLEILPPPPKQKISDPAELADYQQRKRKTFEDNLRKNRMVV 76
            :||||.||.:||:||||||||.||. ::...|||..|:|..||.::|.||||.|||.:|:||:.:
pombe     7 RVKNKNPAPIQISAEQLLREAVERQ-DVAFVPPKINITDLEELQEFQGRKRKEFEDAIRRNRLAM 70

  Fly    77 SHWIKYAQWEEQQQEIQRARSIWERALDNEHRNVTLWLKYAEMEMKNKQVNHARNLWDRAVTIMP 141
            .||::|.|||..|:|..||||::|||||.:...:.|||||.|.||||:.:||||||:|||||.:|
pombe    71 GHWMRYGQWELDQKEFARARSVFERALDVDSTYIPLWLKYIECEMKNRNINHARNLFDRAVTQLP 135

  Fly   142 RVNQFWYKYTYMEEMLENVAGARQVFERWMEWQPEEQAWQTYVNFELRYKEIDRAREIYERFVYV 206
            ||::.||||.||||||.|:.|.|||||||::|:|:|..|.:|:..|.||.|.:|||.||||||.|
pombe   136 RVDKLWYKYVYMEEMLGNITGCRQVFERWLKWEPDENCWMSYIRMERRYHENERARGIYERFVVV 200

  Fly   207 HPDVKNWIKFARFEESHGFIHGSRRVFERAVEFFGDDYIEERLFIAFARFEEGQKEHDRARIIYK 271
            ||:|.||:::|||||..|.....|:|:..|::..|.:::.||.|||||:||..|||::|||.|:|
pombe   201 HPEVTNWLRWARFEEECGNAANVRQVYLAAIDALGQEFLNERFFIAFAKFEIRQKEYERARTIFK 265

  Fly   272 YALDHLPKDRTQELFKAYTKHEKKYGDRAGIEDVIVSKRKYQYEQEVAANPTNYDAWFDYLRLIE 336
            ||:|.:|:.::.||:|.||..||::||..|:|..::.||:.|||:.:..:|.:||.|.|.|:|.|
pombe   266 YAIDFMPRSKSMELYKEYTHFEKQFGDHLGVESTVLDKRRLQYEKLLKDSPYDYDTWLDLLKLEE 330

  Fly   337 AEGDRDQIRETYERAISNVPPANEKNFWRRYIYLWINYALYEELEAEDAERTRQIYKTCLELIPH 401
            :.||.:.||||||:||:.||...|||.||||:|:|:||.|:||::.:|.:|.|::|:..|:||||
pombe   331 SAGDINTIRETYEKAIAKVPEVVEKNAWRRYVYIWLNYCLFEEIDVKDVDRARKVYQEALKLIPH 395

  Fly   402 KQFTFSKLWLLYAQFEIRCKELQRARKALGLAIGMCPRDKLFRGYIDLEIQLREFERCRMLYEKF 466
            |:|||:||||:||.||:|.:::..|||.||.|:||||:.|||||||:.|..:::|:|||:||||:
pombe   396 KKFTFAKLWLMYAMFELRQRKIDVARKTLGRALGMCPKPKLFRGYIEFEDAIKQFDRCRILYEKW 460

  Fly   467 LEFGPENCVTWMKFAELENLLGDTDRARAIFELAVQQPRLDMPELLWKAYIDFEVALGETELARQ 531
            :.:.||.|..|:.:|.||..|||:|||||::.|||.||.|:.|||:||||||||....|...||.
pombe   461 ILYDPEACAPWLGYAALETKLGDSDRARALYNLAVNQPILETPELVWKAYIDFEFEEMEYGKARS 525

  Fly   532 LYERLLERTQHVKVWMSFAKFEMG-LSHGDSGPDAE-----LNVQLARRIYERANEMLRQLGDKE 590
            :|::||....|||||:|||.||:. |...|..|..|     ..|..||.::|.|...|||.|.||
pombe   526 IYQQLLRTAPHVKVWISFANFEIAHLEDDDEEPPNEEVASPTAVVRARNVFENALAHLRQQGLKE 590

  Fly   591 SRVLLLEAWRDFERDASDSQEMQKVMDKMPRRIKKRQKIVSDNGVEEG-WEEVFDYIFPE----- 649
            .||:|||||:.||.........:.|...||:.:|||:::      |:| :||..||:||:
pombe   591 ERVVLLEAWKQFEAMHGTEDTRKHVSSLMPQVVKKRRRL------EDGSFEEYLDYLFPDTATDQ 649

  Fly   650 -DEMARPNLKLLAAAKMWKTQ 669
             |:|.    |:|..::.||.:
pombe   650 GDKMR----KMLELSRKWKEE 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crn	NP_477118.1	HAT	94..122	CDD:214642	16/27 (59%)
		TPR repeat	109..139	CDD:276809	20/29 (69%)
		TPR repeat	144..172	CDD:276809	19/27 (70%)
		RNA14	<180..539	CDD:227438	188/358 (53%)
		HAT	191..222	CDD:111114	20/30 (67%)
		TPR repeat	473..503	CDD:276809	16/29 (55%)
		TPR repeat	508..538	CDD:276809	16/29 (55%)
cwf4	NP_596573.1	RNA14	58..561	CDD:227438	270/502 (54%)
		TPR repeat	73..98	CDD:276809	14/24 (58%)
		HAT	84..116	CDD:214642	17/31 (55%)
		TPR repeat	103..133	CDD:276809	20/29 (69%)
		TPR repeat	138..166	CDD:276809	19/27 (70%)
		HAT	185..216	CDD:111114	20/30 (67%)
		TPR repeat	319..347	CDD:276809	16/27 (59%)
		TPR repeat	361..392	CDD:276809	13/30 (43%)
		HAT	377..413	CDD:214642	21/35 (60%)
		TPR repeat	401..429	CDD:276809	15/27 (56%)
		TPR repeat	434..463	CDD:276809	16/28 (57%)
		TPR repeat	468..495	CDD:276809	14/26 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	356	1.000	Domainoid score	I164
eggNOG	1	0.900	-	-		E1_KOG1915
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6462
Inparanoid	1	1.050	707	1.000	Inparanoid score	I100
OMA	1	1.010	-	-		QHG54523
OrthoFinder	1	1.000	-	-		FOG0003119
OrthoInspector	1	1.000	-	-		oto101164
orthoMCL	1	0.900	-	-		OOG6_101977
Panther	1	1.100	-	-	LDO	PTHR11246
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R208
SonicParanoid	1	1.000	-	-		X2089
TreeFam	1	0.960	-	-
	14	13.860