DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kz and DHX34

DIOPT Version :10

Sequence 1:NP_476591.1 Gene:kz / 31205 FlyBaseID:FBgn0001330 Length:1192 Species:Drosophila melanogaster
Sequence 2:NP_055496.2 Gene:DHX34 / 9704 HGNCID:16719 Length:1143 Species:Homo sapiens


Alignment Length:827 Identity:229/827 - (27%)
Similarity:358/827 - (43%) Gaps:220/827 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   190 SSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRTTE-- 252
            :|..:|.|...|..|.|.....|.:..|   ..:..:..|.|.......:.:  ::|..|..|  
Human    75 TSRKEEKDPGQPKHSIPALADLPRTYDP---RYRINLSVLGPATRGSQGLGR--HLPAERVAEFR 134

  Fly   253 --------------------VQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFL 297
                                :|..|..|||.....::::|:.|:.:|:|||:||.||:||:||:|
Human   135 RALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYL 199

  Fly   298 YEAGYAQHKMIGVTEPRRVAAIAMSKRVAHE-MNLPESEVSYLIRFEGNVTPATRIKFMTDGVLL 361
            ..||::.   :..|:|||:|.|:::|||..| ::...|:|.|.||||...:.||:|.|:|.|:||
Human   200 LAAGFSH---VACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLL 261

  Fly   362 KEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTEN 426
            ::|:.:..|.:|.|:|:||.|||.::.|.|:|:|.|::|.|    ..||:|:||||:.:|.|:. 
Human   262 RQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLPTR----PDLKVILMSATINISLFSS- 321

  Fly   427 TRLFKIPPPLLKVEARQFPVTIHFQKRTPDDYVAEAY----RKTLKI-----HNKLPE--GGILI 480
               :....|:::|..|.||:|:.:|.:..:...:::.    |..|::     |...||  |.:|:
Human   322 ---YFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPRPFLRVLESIDHKYPPEERGDLLV 383

  Fly   481 FVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVI 545
            |::|..|::.::                                 :||.|...            
Human   384 FLSGMAEISAVL---------------------------------EAAQTYAS------------ 403

  Fly   546 RNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMG 610
                                               |.|                           
Human   404 -----------------------------------HTQ--------------------------- 406

  Fly   611 SGQRQPLW-VLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRL 674
                  .| ||||:|.||...|:::|...|.|.|.|::|||:||||:||..|::|||.|:.|...
Human   407 ------RWVVLPLHSALSVADQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMS 465

  Fly   675 YD---KLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVE 736
            ||   ||..:..|   :.|:|||:||.|||||...|.|:|||:.:.| |.|..:..|:|::..::
Human   466 YDPQAKLQRLQEF---WISQASAEQRKGRAGRTGPGVCFRLYAESDY-DAFAPYPVPEIRRVALD 526

  Fly   737 DLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRF 801
            .|:|||:.|.:.....|||..||....|:.|...|...|||        |...|:|.:|.::::.
Human   527 SLVLQMKSMSVGDPRTFPFIEPPPPASLETAILYLRDQGAL--------DSSEALTPIGSLLAQL 583

  Fly   802 PVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRDEDVAPGANRFHRKRQSWAASGN 866
            ||....||||.|....:|:...:.:.||||||.....:.....|..|  |.|.....|       
Human   584 PVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPFTRSAQSSPECAA--ARRPLESDQ------- 639

  Fly   867 YQLLGDPMVLLRAVGA-AEYAGSQGR-LPEFCAANGLRQKAMSEVRKLRVQLTNEINLNVSDVEL 929
                |||..|.....| .:....:.| ..::|...|:.:..:.|:..||.|..          ||
Human   640 ----GDPFTLFNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLYEMANLRRQFK----------EL 690

  Fly   930 GVDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEERRRL 976
            ..|..|.  ..|||        |.:||..:|      :..:.|||.|
Human   691 LEDHGLL--AGAQA--------AQVGDSYSR------LQQRRERRAL 721

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kzNP_476591.1 HrpA 260..>1071 CDD:441249 214/735 (29%)
DEXHc_DHX37 260..439 CDD:350740 72/179 (40%)
DHX34NP_055496.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 75..94 6/18 (33%)
HrpA 160..>624 CDD:441249 182/599 (30%)
DEAH box 279..282 2/2 (100%)
Negatively regulates interaction with UPF1. /evidence=ECO:0000269|PubMed:26841701 701..955 10/35 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 724..766
OB_NTP_bind 800..911 CDD:400182
Required for phosphorylation of UPF1. Not required for interaction with UPF1. /evidence=ECO:0000269|PubMed:26841701 810..1143
Required for the interaction with SMG1 and subsequent phosphorylation of UPF1. /evidence=ECO:0000269|PubMed:26841701 957..1143
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.