DRSC/TRiP Functional Genomics Resources

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Protein Alignment kz and DHX57

DIOPT Version :9

Sequence 1:NP_001284815.1 Gene:kz / 31205 FlyBaseID:FBgn0001330 Length:1192 Species:Drosophila melanogaster
Sequence 2:NP_945314.1 Gene:DHX57 / 90957 HGNCID:20086 Length:1386 Species:Homo sapiens


Alignment Length:1113 Identity:265/1113 - (23%)
Similarity:453/1113 - (40%) Gaps:300/1113 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   164 LVEEEEEL-----------------------QAKRKNP--------------NVISVEEDDEDSS 191
            |:|||.|:                       :.:..||              |.|...|...:|.
Human   414 LLEEESEIVKLLTNTHHKYSDPPVNFLPVPSRTRINNPACHKTVIPNNSFVSNQIPEVEKASESE 478

  Fly   192 SSDEDDEEAPAQSAPIAIPTPVSIA-PPQIAVKPPI--------KKLKPEPNPPACIHQTVYVPV 247
            .|||||.           |.||.:. ...:.:|..|        |.:..| |...|....:....
Human   479 ESDEDDG-----------PAPVIVENESYVNLKKKISKRYDWQAKSVHAE-NGKICKQFRMKQAS 531

  Fly   248 HRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGY--AQHKMIGV 310
            .:...:...|..||...|.:.::..:.::.:|:::|.||.|||||:|||:.:...  ...|:..:
Human   532 RQFQSILQERQSLPAWEERETILNLLRKHQVVVISGMTGCGKTTQIPQFILDDSLNGPPEKVANI 596

  Fly   311 --TEPRRVAAIAMSKRVAHEMNLPESE-----VSYLIRFEGNVTPATRIKFMTDGVLLKEIETDF 368
              |:|||::||::::|||.|    .:|     |.|.||.|...:.|||:.:.|.||||:.:|.|.
Human   597 ICTQPRRISAISVAERVAKE----RAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDT 657

  Fly   369 LLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRV---SDFTENTRLF 430
            .|...|.||:||.|||:..:|.|:.:|..||..|    ..|::|:|||||..   ||:..:.   
Human   658 ALQGVSHIIVDEVHERTEESDFLLLVLKDIVSQR----PGLQVILMSATLNAELFSDYFNSC--- 715

  Fly   431 KIPPPLLKVEARQFPVTIHFQKRTPDDYVA---------EAYRKTLKIHNKLPEGGILIFVTGQQ 486
                |::.:..|.|||...|.    :|.:|         ..|.:::|..:|              
Human   716 ----PVITIPGRTFPVDQFFL----EDAIAVTRYVLQDGSPYMRSMKQISK-------------- 758

  Fly   487 EVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEET------IDDAASTVEDPKELEFDMKRVI 545
                  .||:             |:..:.:.||.||.      :.|..|..:...:.:.|.|:::
Human   759 ------EKLK-------------ARRNRTAFEEVEEDLRLSLHLQDQDSVKDAVPDQQLDFKQLL 804

  Fly   546 ---RNIRKSKKKFLAQMALPKINLD----------DYK-----------LPGDDTEADMHEQPDE 586
               :.:.||..|.::.|...|:||:          |.|           |||......::||   
Human   805 ARYKGVSKSVIKTMSIMDFEKVNLELIEALLEWIVDGKHSYPPGAILVFLPGLAEIKMLYEQ--- 866

  Fly   587 DDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNV 651
                            |:..|...:.:.....:.||:|.||||:|..:|:..|.|....::|||:
Human   867 ----------------LQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPAGVTKIIISTNI 915

  Fly   652 AETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSA 716
            ||||:||..:.||:|.|:.|.:.||...|:.:...|:.|:|:|.||.|||||:::|.|:.|::|.
Human   916 AETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSH 980

  Fly   717 VYNDCFEDFSQPDIQKKPVEDLMLQMRCMGI----------DRVVHFPFPSPPDQVQLQAAERRL 771
            .||........|:||:.|:|.|.|:::.:.:          .|::     .||....|:|::.||
Human   981 HYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSAHNLQSVFSRLI-----EPPHTDSLRASKIRL 1040

  Fly   772 IVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVL 836
            ..||||    |.:..|.|    ||:.::..||..|.||::........|...:.:.|:|:.:...
Human  1041 RDLGAL----TPDERLTP----LGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPF 1097

  Fly   837 IETGVQRDEDVAPGANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPE------- 894
            :....:::|     ||   :|:..:|.:.:     |.:.||:|     |.|.|....|       
Human  1098 VSPWDKKEE-----AN---QKKLEFAFANS-----DYLALLQA-----YKGWQLSTKEGVRASYN 1144

  Fly   895 FCAANGLRQKAMSEVRKLRVQLTNEIN--------LNVSDVE---------LGVDPELKPPTDAQ 942
            :|..|.|..:.:.|:..|:.|.|..::        |...::|         |....|........
Human  1145 YCRQNFLSGRVLQEMASLKRQFTELLSDIGFAREGLRAREIEKRAQGGDGVLDATGEEANSNAEN 1209

  Fly   943 ARFLRQILLAGMGDRVA---------RKVPLADIADKEERRRLKYAYNCADMEEPAFLHV--SSV 996
            .:.:..:|.|.:...|.         :|.....:..:.:...||:.     .:...::|:  |||
Human  1210 PKLISAMLCAALYPNVVQVKSPEGKFQKTSTGAVRMQPKSAELKFV-----TKNDGYVHIHPSSV 1269

  Fly   997 ---LRQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVPLLCNIREVR-------EDP 1051
               :|.....:::|.|..:     ::::|||..:.:....|:|:.....|::..|       :|.
Human  1270 NYQVRHFDSPYLLYHEKIK-----TSRVFIRDCSMVSVYPLVLFGGGQVNVQLQRGEFVVSLDDG 1329

  Fly  1052 APRFDKTSGKIF-------CHVDATFGKSGWELPLGEVEMPLSEKACCYFGMFLLDGEVCSRLAD 1109
            ..||...|.::.       |.:|        :|...:::.|..:...|..|         ||:..
Human  1330 WIRFVAASHQVAELVKELRCELD--------QLLQDKIKNPSIDLCTCPRG---------SRIIS 1377

  Fly  1110 FRSKLKST 1117
            ...||.:|
Human  1378 TIVKLVTT 1385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kzNP_001284815.1 HrpA 237..1058 CDD:224557 229/926 (25%)
DEXDc 279..418 CDD:238005 59/147 (40%)
P-loop_NTPase 369..>500 CDD:304359 37/142 (26%)
HELICc 619..704 CDD:197757 38/84 (45%)
HA2 774..859 CDD:214852 21/84 (25%)
OB_NTP_bind 915..1039 CDD:285018 24/154 (16%)
DHX57NP_945314.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..106
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 120..147
UBA_DHX57 181..218 CDD:270502
RWD 243..418 CDD:283440 2/3 (67%)
ZnF_C3H1 303..323 CDD:214632
DEXDc 550..730 CDD:214692 68/194 (35%)
DEXDc 561..703 CDD:238005 59/149 (40%)
DEVH box 668..671 2/2 (100%)
Helicase_C 832..968 CDD:278689 47/154 (31%)
HA2 1043..1125 CDD:214852 23/102 (23%)
OB_NTP_bind 1164..1310 CDD:285018 24/155 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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