Protein Alignment kz and PRP2

DIOPT Version :10

• Sequence 1: NP_476591.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_014408.1
• Gene: PRP2 / 855745
• SGDID: S000005294
• Length: 876
• Species: Saccharomyces cerevisiae
• Alignment Length: 1086
• Identity: 299/1086 - (27%)
• Similarity: 470/1086 - (43%)
• Gaps: 309/1086 - (28%)

  Fly    20 NSA--VKKIQIDVDAVAGGNQVGYDEANALVLPSEKRATKIKVDKVQHVKILSKKQRKHLQAIVD 82
            |||  :|:.:.|.:.|......|.::.|   |..|:..::.|..|... ||.|..:      :..
Yeast    46 NSALQLKRSRYDPNKVFSNTNQGPEKNN---LKGEQLGSQKKSSKYDE-KITSNNE------LTT 100

  Fly    83 KKKKKEGRAQLLGDLAAVQIPEEELQQYTSISQVQ---TVGLKRLPTLDEYLAKKKERQAQVLAE 144
            ||       .||||      .|.|.:..:|.|:..   |..:|....:|:...::...:.|
Yeast   101 KK-------GLLGD------SENETKYASSNSKFNVEVTHKIKNAKEIDKINRQRMWEEQQ---- 148

  Fly   145 KSSASGLRVNAIKGSKRKLLVEEEEELQAKRKNPNVISVEEDDE-----DSSS----SDEDDEEA 200
                  || ||:.|               :..:|:.|::|..|:     |:.:    ::|:|:..
Yeast   149 ------LR-NAMAG---------------QSDHPDDITLEGSDKYDYVFDTDAMIDYTNEEDDLL 191

  Fly   201 PAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRTTEVQNARLRLPILAE 265
            |.:                        ||:.|    |.:.|.:.....|...:|.||..||:...
Yeast   192 PEE------------------------KLQYE----ARLAQALETEEKRILTIQEARKLLPVHQY 228

  Fly   266 EQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYA-QHKM-IGVTEPRRVAAIAMSKRVAHE 328
            :.::::.|.:|.::|:.|||||||||||||:|.|.|:. |.|: |.:|:||||||.:::.|||.|
Yeast   229 KDELLQEIKKNQVLIIMGETGSGKTTQLPQYLVEDGFTDQGKLQIAITQPRRVAATSVAARVADE 293

  Fly   329 MNLP-ESEVSYLIRFEGNVTP-ATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDIL 391
            ||:. ..||.|.||||...|| .|.:|:||||:||:|..||..|||||.|::||||||::.||||
Yeast   294 MNVVLGKEVGYQIRFEDKTTPNKTVLKYMTDGMLLREFLTDSKLSKYSCIMIDEAHERTLATDIL 358

  Fly   392 VGLLSRIVPLRHKRGQPLKLIIMSATL---RVSDFTENTRLFKIPPPLLKVEARQFPVTIHFQKR 453
            :|||..|:|.|    ..|||:|.|||:   :.|:|.:|..:|.:|       .|::||.||:..:
Yeast   359 IGLLKDILPQR----PTLKLLISSATMNAKKFSEFFDNCPIFNVP-------GRRYPVDIHYTLQ 412

  Fly   454 TPDDYVAEAYRKTLKIH--NKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVS 516
            ...:|:..|.....:||  ..|| |.||:|:|||:|:.:...||
Yeast   413 PEANYIHAAITTIFQIHTTQSLP-GDILVFLTGQEEIERTKTKL--------------------- 455

  Fly   517 EEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMH 581
                ||.:
Yeast   456 ----EEIM--------------------------------------------------------- 459

  Fly   582 EQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCV 646
                                     |.:||..:|.: :.|:|:.|..|:|.:||.|.|:.||..|
Yeast   460 -------------------------SKLGSRTKQMI-ITPIYANLPQEQQLKIFQPTPENCRKVV 498

  Fly   647 VSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYR 711
            ::||:|||||||..|:||:|.|..|...|...||::..:....|:||.|||||||||:..|.|:|
Yeast   499 LATNIAETSLTIDGIRYVIDPGFVKENSYVPSTGMTQLLTVPCSRASVDQRAGRAGRVGPGKCFR 563

  Fly   712 LYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGA 776
            :::...|....|...:|:|.:..:.:.:|.:..:|:..::.||....|....|:.:...|.:|||
Yeast   564 IFTKWSYLHELELMPKPEITRTNLSNTVLLLLSLGVTDLIKFPLMDKPSIPTLRKSLENLYILGA 628

  Fly   777 LEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKML--ALSHQQNLLPYTVC---LVAALSVQEVL 836
            |....|        :||||.::..||..|.|.|:|  |.:|:|       |   |...|::..:|
Yeast   629 LNSKGT--------ITRLGKMMCEFPCEPEFAKVLYTAATHEQ-------CQGVLEECLTIVSML 678

  Fly   837 IET-----GVQRDEDVAPGANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEF- 895
            .||     |.:||.                |||...::..|.::.|...       :|.|..:|
Yeast   679 HETPSLFIGQKRDA----------------AASVLSEVESDHILYLEIF-------NQWRNSKFS 720

  Fly   896 ---CAANGLRQKAMSEVRKLRVQL---TNEINLNVSDVELGVDPELKPPTDA---QARFLRQILL 951
               |..:.::.|.|..||.:|.||   :.::.|    ||......:|....|   .||..| ..:
Yeast   721 RSWCQDHKIQFKTMLRVRNIRNQLFRCSEKVGL----VEKNDQARMKIGNIAGYINARITR-CFI 780

  Fly   952 AGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSVL-------RQKAPEWVIYQE 1009
            :|....:.:..|    ...:...|.....|.:       :|.:|:|       .|:..::|:||:
Yeast   781 SGFPMNIVQLGP----TGYQTMGRSSGGLNVS-------VHPTSILFVNHKEKAQRPSKYVLYQQ 834

  Fly  1010 AYELQNGDSTKMFIRGITAI-EPEWLLLYVPLLCNIREVREDPAPR 1054
            ...     ::|.|||....| :.|||:..||.:  .:::.:|...|
Yeast   835 LML-----TSKEFIRDCLVIPKEEWLIDMVPQI--FKDLIDDKTNR 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_476591.1	HrpA	260..>1071	CDD:441249	248/832 (30%)
		DEXHc_DHX37	260..439	CDD:350740	91/185 (49%)
PRP2	NP_014408.1	PTZ00121	<7..174	CDD:173412	38/176 (22%)
		HrpA	223..>738	CDD:441249	212/672 (32%)
		OB_NTP_bind	775..862	CDD:400182	22/103 (21%)