Protein Alignment kz and PRP16

DIOPT Version :10

• Sequence 1: NP_476591.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_013012.3
• Gene: PRP16 / 853961
• SGDID: S000001794
• Length: 1071
• Species: Saccharomyces cerevisiae
• Alignment Length: 1138
• Identity: 304/1138 - (26%)
• Similarity: 491/1138 - (43%)
• Gaps: 311/1138 - (27%)

  Fly    25 KIQIDVDAVAGGNQVGYDEANALV--LPSEKRATKIKVDKVQHVKILSKKQRKHLQAIVD----- 82
            |||:|:|    .|:   ||.::.|  .|:..|....::||::     :|:.|::...:.|
Yeast    94 KIQLDLD----DNE---DELDSPVQKKPAPTRTLFKRIDKLK-----AKQLRQYSPTVKDPSPNS 146

  Fly    83 KKKKKEGRAQL-----------------------LGDLA---AVQIPEEE--LQQYTSIS----- 114
            :::.:.|.|:.                       .|:|.   ..::|||.  |....:|.
Yeast   147 EQQTQNGHAETKDYEPTRSEVVEEDREWYDNDDDYGNLVPEPLSELPEEAKLLPVIRNIDNDDAL 211

  Fly   115 ----QVQTVGLKRL-----PTLDEYLAKKK-----------ERQAQVLA------EKSSASGLRV 153
                |:..:.||:.     |.|.::..:.|           |..:||.|      .::..|....
Yeast   212 RNTVQLYPIPLKQRMEWIPPFLSKFALENKVPTSIIIGSISETSSQVSALSMVNPFRNPDSEFSA 276

  Fly   154 NAIKGSK----RKLLVEEEEELQAKRKNPNVISVEEDDEDSSSSDEDDEEAPAQSAPIAIPTPVS 214
            ||.:|||    |::   ..|.:|..|.|..|::.
Yeast   277 NAKRGSKLVALRRI---NMEHIQQSRDNTTVLNT------------------------------- 307

  Fly   215 IAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRTTEVQNARLRLPILAEEQQVMETINENPIV 279
             |..::.......|.|.:.|...|....::.|  ...::::.:.:||:.....|::..|.||.:|
Yeast   308 -AMGEVLGLENNNKAKDKSNQKICDDTALFTP--SKDDIKHTKEQLPVFRCRSQLLSLIRENQVV 369

  Fly   280 IVAGETGSGKTTQLPQFLYEAGYA--QHKMIGVTEPRRVAAIAMSKRVAHEMNLP-ESEVSYLIR 341
            ::.|||||||||||.|:|||.|||  :.|.|.||:|||||||:::||||.||.:| ..||.|.||
Yeast   370 VIIGETGSGKTTQLAQYLYEEGYANDRGKSIVVTQPRRVAAISVAKRVAMEMQVPLGKEVGYSIR 434

  Fly   342 FEGNVTPA--TRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHK 404
            || :||.:  |::||:|||:||:|...|..|.|||.:|:|||||||:.||||:|....::    .
Yeast   435 FE-DVTDSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILL----A 494

  Fly   405 RGQPLKLIIMSATL---RVSDFTENTRLFKIPPPLLKVEARQFPVTIHFQKRTPDDYVAEAYRKT 466
            |.:.|||||.|||:   :.|.|..|...|.||       .|.|||...:......|||..|..:.
Yeast   495 RRRDLKLIITSATMNAKKFSAFFGNAPQFTIP-------GRTFPVQTIYTSNPVQDYVEAAVSQA 552

  Fly   467 LKIH--NKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAAS 529
            :|||  |....|.||||:|||:::                                |.|.|
Yeast   553 VKIHLANDCSSGDILIFMTGQEDI--------------------------------ETTFD---- 581

  Fly   530 TVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLE 594
            |:::                    ||| |:...|....::                        |
Yeast   582 TLQE--------------------KFL-QVYSKKFGTANF------------------------E 601

  Fly   595 EDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIP 659
            |.||.|                  :||:||.|.::.|.:||..:....|..:::||:|||||||.
Yeast   602 EINDIE------------------ILPIYSALPADLQFKIFQDLHGTKRKIIIATNIAETSLTIK 648

  Fly   660 HIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFED 724
            .|:||:|||..|.::|:...|:.:.|:|..|||:||||:|||||.:.|..||||:...:.:....
Yeast   649 GIRYVIDCGYSKLKVYNPKIGLDSLVITPISKANADQRSGRAGRTAPGTAYRLYTEDTFKEDMYL 713

  Fly   725 FSQPDIQKKPVEDLMLQMRCMGI-DRVVHFPF-PSPPDQVQLQAAERRLIVLGALEVAKTENTDL 787
            .:.|:||:..:.:.:|.::.:.: |.:..||| ..||.|..|.:. ..|..:||:        |.
Yeast   714 QTIPEIQRTNLSNTLLLLKSLDVTDELSKFPFIDKPPLQTFLSSL-YELWFIGAI--------DT 769

  Fly   788 PPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGV-QRDEDVAPGA 851
            ...:|.||..:::||:.|...|:|.::.:.......:.:|:.|||.:|...... |::.|:|  .
Yeast   770 SGQLTPLGLQMAKFPLQPSLSKILLIAVRNGCSDEMLTIVSMLSVPQVFYRPKERQKEADIA--R 832

  Fly   852 NRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEF----CAANGLRQKAMSEVRKL 912
            |:|            :....|.:.||...       .|.|...|    |..:.::.|::...|.:
Yeast   833 NKF------------FIAKSDHLTLLNVF-------EQWRANNFSSHWCNKHFVQYKSLVRARDI 878

  Fly   913 RVQLTNEI-NLNVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEERRRL 976
            |.||...: :..:..:..|.|.::          :::.:.:|...:.|:...|.:..      .|
Yeast   879 RDQLLTILKSQKIPVISSGKDWDI----------IKKCICSGFAHQAAKITGLRNYV------HL 927

  Fly   977 KYAYNCADMEEPAFLHVSSVLR--QKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVP 1039
            |...:..       ||.:|.|.  ...|.:|:|.|...     ::|.:|..:|:::|.||:.|..
Yeast   928 KTGVSVQ-------LHPTSALHGLGDLPPYVVYHELLM-----TSKEYICCVTSVDPFWLMEYGG 980

  Fly  1040 LLCNIREVREDPAPRFDKTSGKIFCHVDATFGK 1072
            ||.:|:.::.|...   .|:|....|.:.|..|
Yeast   981 LLYDIKRIKNDQEA---TTTGLFGEHYEHTLDK 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_476591.1	HrpA	260..>1071	CDD:441249	250/830 (30%)
		DEXHc_DHX37	260..439	CDD:350740	94/186 (51%)
PRP16	NP_013012.3	HrpA	348..>980	CDD:441249	242/800 (30%)