Protein Alignment kz and DHX16

DIOPT Version :9

• Sequence 1: NP_001284815.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_003578.2
• Gene: DHX16 / 8449
• HGNCID: 2739
• Length: 1041
• Species: Homo sapiens
• Alignment Length: 1071
• Identity: 291/1071 - (27%)
• Similarity: 462/1071 - (43%)
• Gaps: 290/1071 - (27%)

  Fly    41 YDEANALVLPSEKRATKIKVDKVQHVKILSKKQRKHLQAIVDKKKKKEGRAQ------LLGDLAA 99
            |:||       :||....:.|:...|..|.||.|:...|..:::|.::..|:      |.||
Human   205 YEEA-------QKRLKMAEEDRKAMVPELRKKSRREYLAKREREKLEDLEAELADEEFLFGD--- 259

  Fly   100 VQIPEEELQQYTSISQVQTVG--------LKRLPTLDEYLAKKKER----QAQVLAEKSSAS--- 149
            |::...|.|:.....:|:.:.        .::|...:.|...|:.|    :|..|.|:.|.:
Human   260 VELSRHERQELKYKRRVRDLAREYRAAGEQEKLEATNRYHMPKETRGQPARAVDLVEEESGAPGE 324

  Fly   150 -----------------GLRVNAIKGSKRKLLVEEEEELQAKRKNPNVISVEEDDEDSSSSDEDD 197
                             |.|..|.:..|.:|::||||.::..|               ::..:.|
Human   325 EQRRWEEARLGAASLKFGARDAASQEPKYQLVLEEEETIEFVR---------------ATQLQGD 374

  Fly   198 EEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRTTEVQNARLRLPI 262
            ||      |.|.||...                                ..:...:|..|..||:
Human   375 EE------PSAPPTSTQ--------------------------------AQQKESIQAVRRSLPV 401

  Fly   263 LAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQHKM-IGVTEPRRVAAIAMSKRVA 326
            ....::::..|..:.::|:.||||||||||:||:|:|.||....| |..|:||||||::::.|||
Human   402 FPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRRVAAMSVAARVA 466

  Fly   327 HEMNLP-ESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDI 390
            .||.:. .:||.|.||||...:..|.:::||||:||:|..::..|:.|||:::||||||:::|||
Human   467 REMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDI 531

  Fly   391 LVGLLSRIVPLRHKRGQPLKLIIMSATL---RVSDFTENTRLFKIPPPLLKVEARQFPVTIHFQK 452
            |.||:..:...|.:    ||:::.|||:   |.|.|.::..:|:||       .|:|||.|.:.|
Human   532 LFGLIKDVARFRPE----LKVLVASATMDTARFSTFFDDAPVFRIP-------GRRFPVDIFYTK 585

  Fly   453 RTPDDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSE 517
            ....||:.......|:||...|.|.||:|:|||:|
Human   586 APEADYLEACVVSVLQIHVTQPPGDILVFLTGQEE------------------------------ 620

  Fly   518 EEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHE 582
                  |:.|...::|             ..|:
Human   621 ------IEAACEMLQD-------------RCRR-------------------------------- 634

  Fly   583 QPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVV 647
                                      :||..|: |.|||:|:.|.|:.|.|||.|.|.|.|..||
Human   635 --------------------------LGSKIRE-LLVLPIYANLPSDMQARIFQPTPPGARKVVV 672

  Fly   648 STNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRL 712
            :||:|||||||..|.||:|.|..|.:.|:..||:.:..||..|||||:||||||||::||.|:||
Human   673 ATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRL 737

  Fly   713 YSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGAL 777
            |::..|....|:.:.|:||:..:.:::|.::.:||..::||.|..||....|..|..:|..||||
Human   738 YTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGAL 802

  Fly   778 EVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQ 842
            ...        ..:|..|..::..||.|...||:..|.:.:.....:.:.|.|||...:
Human   803 NHL--------GELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSI------ 853

  Fly   843 RDEDVAPGANRFHRKRQSWAASGNYQLL-----GDPMVLLRAVGAAEYAGSQGRLPEFCAANGLR 902
                       |:|.:.....:.|.::.     ||.:|||...  .::|.| |...::|..|.::
Human   854 -----------FYRPKDKVVHADNARVNFFLPGGDHLVLLNVY--TQWAES-GYSSQWCYENFVQ 904

  Fly   903 QKAMSEVRKLRVQLTNEINLNVSDVELGVDPELKPPTDAQARFL--RQILLAGMGDRVARKVPLA 965
            .::|...|.:|.||...:    ..||:|:       :..|..::  |:.:.||.....||..
Human   905 FRSMRRARDVREQLEGLL----ERVEVGL-------SSCQGDYIRVRKAITAGYFYHTARLT--- 955

  Fly   966 DIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITAIE 1030
                       :..|.....::..|:|.:|.|.::.|.|::|.|...     :||.|:|.:..||
Human   956 -----------RSGYRTVKQQQTVFIHPNSSLFEQQPRWLLYHELVL-----TTKEFMRQVLEIE 1004

  Fly  1031 PEWLLLYVPLLCNIREVREDPAPRFDKTSGK 1061
            ..|||...|.....:|:.:..|.:..|..||
Human  1005 SSWLLEVAPHYYKAKELEDPHAKKMPKKIGK 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	242/832 (29%)
		DEXDc	279..418	CDD:238005	67/140 (48%)
		P-loop_NTPase	369..>500	CDD:304359	48/133 (36%)
		HELICc	619..704	CDD:197757	48/84 (57%)
		HA2	774..859	CDD:214852	18/84 (21%)
		OB_NTP_bind	915..1039	CDD:285018	29/125 (23%)
DHX16	NP_003578.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..207		1/1 (100%)
		PTZ00121	<148..376	CDD:173412	40/195 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	371..391		7/57 (12%)
		HrpA	390..1028	CDD:224557	242/814 (30%)
		DEAH box	520..523		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820