DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and tdrd9

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_012824154.2	Gene:	tdrd9 / 780352	XenbaseID:	XB-GENE-5893104	Length:	1346	Species:	Xenopus tropicalis

Alignment Length:	841	Identity:	205/841 - (24%)
Similarity:	369/841 - (43%)	Gaps:	174/841 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 LPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFL--YEAGYAQHKMIGVTEPRRVAAIAMS 322
            ||||...::::..|..|.:|::.|.|||||:||||||:  |...:.|:..|.||:||::||.:::
Frog   104 LPILKSREELIALIENNSVVVIHGATGSGKSTQLPQFILDYLRQHGQYCNIVVTQPRKIAARSIA 168

  Fly   323 KRVAHEMNLP-ESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSV 386
            ..::::.... ...|.|.:..|...:..|::.:||.||||::|.:...|.:::.|.:||.|||:.
Frog   169 TWISNQRCWTLGGRVGYQVGLEKVASEETQLIYMTTGVLLQKIVSAKSLLEFTHIFIDEVHERTE 233

  Fly   387 YTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPPPLLKVEARQFPVTIHFQ 451
            ..|.|:.::.:::....:.   :|:|:||||:...:|.:   .|.:|     |..:..|..|...
Frog   234 EMDFLLMVVRKLLCTNSRF---VKVILMSATINCKEFAD---YFAVP-----VLNKMTPAYIFEV 287

  Fly   452 KRTPDDYVAEAYRKTLKIHNKLPEGGILIFVTGQ----QEVNQLVRKLRRTFPYHHAPTKDVAKN 512
            :..|.| :...|...||   .:|:..|....:.:    :|:.::...|...|   ....|:..|.
Frog   288 EGKPHD-IEVFYLDDLK---DIPQAKIAAHYSDEPLISKEMYEVATSLIHLF---DEMEKEELKK 345

  Fly   513 GKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTE 577
            ||:|.:          :.:|....|.|                     ||.:...:|
Frog   346 GKMSHK----------AYIESNSVLVF---------------------LPGLMEINY-------- 371

  Fly   578 ADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGC 642
              |||.                         ..:..::.|.|.||:|.::.::||.:|:|...|.
Frog   372 --MHEL-------------------------FTNMVQKRLHVYPLHSSITLDEQNLVFMPPVIGY 409

  Fly   643 RLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAG 707
            |..::|||:||:|:|:|.:|||:|....||.:.|:.|...:..:::.||.:.|||.|||||:|.|
Frog   410 RKVILSTNIAESSITVPDVKYVIDFCLTKTLVCDEETNYQSLRLSWASKTNCDQRKGRAGRVSKG 474

  Fly   708 HCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRC--MGIDRVVHFPFPSPPDQVQLQAAERR 770
            :|||......:.:...:...|::.:.|:...:|:::.  ||..|.:.....|||:...::.....
Frog   475 YCYRFVQKDFWKNIIPENVIPEMLRSPLGSTILKVKLLDMGEPRALLATALSPPNITDIERTILL 539

  Fly   771 LIVLGALEVA-KTENTD-LPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQ 833
            |..||||.|: |.||.: ....:|.||.|:::.||..:.||::.|.|....|...:.:.||||::
Frog   540 LKELGALAVSGKRENENPYDGELTFLGKVLAQLPVDLQLGKLIVLGHVFGCLEECIIIAAALSLK 604

  Fly   834 EVLIETGVQRDEDVAPGANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLP----- 893
            ...          ..|..:.....|...:.||:.:  .|.:.|:.|..:.:....:|.|.
Frog   605 NFF----------AMPFRHLLDGYRSKLSFSGSSR--SDCIALVDAFKSWQSCKERGELRLSKDE 657

  Fly   894 -EFCAANGLRQKAMSEVRKLRVQLTNEI---NLNVSDVELGVDPELKPPTDAQARFLRQILLAG- 953
             |:...|..:.|.:.||..|...|...|   |::|:      .|...|..:.:.||:.||::||
Frog   658 LEWGKRNYFQIKRIREVAALYDDLKKRISHFNMHVT------QPARDPDYNFKQRFILQIVMAGA 716

  Fly   954 -------MGDRVARKVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQKAPEW--VIYQE 1009
                   .|....|.. :.|::.|:.|                    ::|:.:..|.:  :.|::
Frog   717 FYPNYFTFGQSDERSA-VRDLSAKDPR--------------------TTVVLKNVPNYSFLYYKQ 760

  Fly  1010 AYEL--QNG-------DSTKMFI----------RGITAI--EPEWLLLYVPLLCNIREVRE 1049
            ...|  |.|       |.::.|:          :.:||:  ..:...|.:||:.|:....:
Frog   761 IQSLFRQCGQVKSILFDGSRAFVEFSRNPTERFKTLTAVYLALKMAQLKIPLILNVHPTED 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	205/841 (24%)
		DEXDc	279..418	CDD:238005	47/141 (33%)
		P-loop_NTPase	369..>500	CDD:304359	30/134 (22%)
		HELICc	619..704	CDD:197757	35/84 (42%)
		HA2	774..859	CDD:214852	24/86 (28%)
		OB_NTP_bind	915..1039	CDD:285018	28/157 (18%)
tdrd9	XP_012824154.2	HrpA	60..>677	CDD:224557	173/668 (26%)
tdrd9	XP_012824154.2	Tudor_TDRD9	872..972	CDD:410502
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910