DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and Tdrd9

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_083332.1	Gene:	Tdrd9 / 74691	MGIID:	1921941	Length:	1383	Species:	Mus musculus

Alignment Length:	899	Identity:	229/899 - (25%)
Similarity:	383/899 - (42%)	Gaps:	212/899 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 QLLGDLAA--VQIPEEELQQYTSISQVQTVGLKRLPTLDEYLAKKKERQAQVLAEKSSASGLRVN 154
            :|||...|  .:.|.||:|:...:.........::|......|:......:.|:::||
Mouse    24 ELLGLPPAFPAEAPREEVQRSEEVPNEDPTAQAQVPVKATAPARPASTSGRSLSQRSS------- 81

  Fly   155 AIKGSKRKLLVEEEEELQAKRKNPNVISVEEDDEDSSSSDEDDEEAPAQSAPIAIPTPVSIAPPQ 219
                        |.|.:...|:      :||.:.|....|:                     ||.
Mouse    82 ------------EMEYINKYRQ------LEEQELDIYGQDQ---------------------PPS 107

  Fly   220 -IAVKPPIKKLKPEPNPPACIHQTVY----VPVHRTTEVQNARLRLPILAEEQQVMETINENPIV 279
             ..::.|:.||    :..|||.:|.|    :|::|..|               :|:..|..|.:|
Mouse   108 GPGLRSPLAKL----SNVACIPETTYKYPDLPINRCKE---------------EVISLIESNSVV 153

  Fly   280 IVAGETGSGKTTQLPQFLYEAGYAQHKM---IGVTEPRRVAAIAMSKRVAHEMNLP-ESEVSYLI 340
            |:.|.|||||:|||||::.: .|.|...   |.||:||::.|.::::.::.|.:.. ...|.|.:
Mouse   154 IIHGATGSGKSTQLPQYVLD-HYTQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLVGYQV 217

  Fly   341 RFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKR 405
            ..|...|..||:.:||.||||::|.:...|.:::.|.:||.|||:...|.|:.::.:::   ...
Mouse   218 GLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLL---RTN 279

  Fly   406 GQPLKLIIMSATLRVSDFTENTRLFKIPPPLLKVEARQFPVTIHFQKRTPDDYVAEAYRKTLKIH 470
            .:.:|:::||||:....|.:   .|.:|     |:.:..|.           ||.|...|...|.
Mouse   280 SRFVKVVLMSATINCKQFAD---YFAVP-----VQNKMNPA-----------YVFEVEGKPHAIE 325

  Fly   471 NKLPEGGILIFVTGQQEVNQLVRKLRRTFPYH-HAP--TKDVAKNGKVSEEEKEETIDDAASTVE 532
                          :..:|.|........||. ..|  ||||              .:.|.|.::
Mouse   326 --------------EYYLNDLGHIYHSGLPYRLEEPVITKDV--------------YEVAVSLIQ 362

  Fly   533 DPKELEFDMKRVIRNIRKSKKKFLAQMA-----LPKINLDDYKLPGDDTEADMHEQPDEDDEQEG 592
            ...:|  |||. ..|...|..:|:::.:     ||.:...:|          |||.
Mouse   363 MFDDL--DMKE-SGNKTWSGAQFVSERSSVLVFLPGLGEINY----------MHEL--------- 405

  Fly   593 LEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFL-PVPDGCRLCVVSTNVAETSL 656
                            :.:...:.|.|.||:|.::.|:||.:|| ||| |.|..::|||:||:|:
Mouse   406 ----------------LTNMIHKRLQVYPLHSSVTLEEQNNVFLSPVP-GYRKIILSTNIAESSV 453

  Fly   657 TIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDC 721
            |:|.:|||:|....:|.:.|:.|...:..:::.||.|.|||.|||||:|.|:||||.....::..
Mouse   454 TVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCDQRKGRAGRVSKGYCYRLIPRDFWDSA 518

  Fly   722 FEDFSQPDIQKKPVEDLMLQMRC--MGIDRVVHFPFPSPPDQVQLQAAERRLIVL---GALEVAK 781
            ..|...|::.:.|:...:|:::.  ||..|.:.....|||   .|...||.:::|   |||.|:.
Mouse   519 IPDHVVPEMLRCPLGSTILKVKLLDMGEPRALLATALSPP---SLSDIERTILLLKEVGALAVSG 580

  Fly   782 TENTDLP--PAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRD 844
            ....:.|  ..:|.||.|:::.||:.:.||::.|.|....|...:.:.||||::...
Mouse   581 QREDENPHDGELTFLGRVLAQLPVSQQLGKLVVLGHVFGCLDECLIIAAALSLKNFF-------- 637

  Fly   845 EDVAPGANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLP------EFCAANGLRQ 903
              ..|........|.....||:.:  .|.:.|:.|..|.:....:|.|.      ::...|.::.
Mouse   638 --TMPFRQHLDGYRNKVHFSGSSR--SDCLALVEAFRAWQACRQRGELRRPKDELDWGRLNYIQI 698

  Fly   904 KAMSEVRKLRVQLTNEINLNVSDVELGVDPELKPPTDAQ----ARFLRQILLAG 953
            |.:.||.:|..:|.|.|    |...:.|.|. .|..|.:    .||:.|::|||
Mouse   699 KRIREVAELYEELKNRI----SQFNMFVGPH-HPVLDQEYPYKQRFILQVVLAG 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	204/751 (27%)
		DEXDc	279..418	CDD:238005	48/142 (34%)
		P-loop_NTPase	369..>500	CDD:304359	26/130 (20%)
		HELICc	619..704	CDD:197757	39/85 (46%)
		HA2	774..859	CDD:214852	22/89 (25%)
		OB_NTP_bind	915..1039	CDD:285018	14/43 (33%)
Tdrd9	NP_083332.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..82		9/65 (14%)
		HrpA	111..>717	CDD:224557	196/733 (27%)
		DEXDc	151..292	CDD:238005	48/144 (33%)
		DEAH box. /evidence=ECO:0000269\|PubMed:28633017	256..259		2/2 (100%)
		Helicase_C	384..501	CDD:278689	46/152 (30%)
		HA2	589..666	CDD:214852	20/88 (23%)
		TUDOR	905..1014	CDD:278965
		TUDOR	950..997	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810