DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and dhx40

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001184155.2	Gene:	dhx40 / 733877	XenbaseID:	XB-GENE-995801	Length:	744	Species:	Xenopus tropicalis

Alignment Length:	845	Identity:	253/845 - (29%)
Similarity:	382/845 - (45%)	Gaps:	192/845 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 QTVYVPVHRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQH 305
            ::.|.|:            |||...:.::::...:||.:||.|:|||||||||||:||:||:.::
Frog    14 ESFYNPI------------LPIHRWKGELVKAATDNPFLIVMGDTGSGKTTQLPQYLYKAGFGKN 66

  Fly   306 KMIGVTEPRRVAAIAMSKRVAHEMNLP-ESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFL 369
            .|||||:|||||.|::::|||.|||.. .|.|.|.:||:...:..|.||:||||.||:....|..
Frog    67 GMIGVTQPRRVATISVAQRVAEEMNCSLGSTVGYQVRFDDCTSERTVIKYMTDGCLLRNTLADPD 131

  Fly   370 LSKYSVIILDEAHERSVYTDILVGLLSRIVPLR--HKRGQPLKLIIMSATL---RVSDFTENTRL 429
            |:|||.|:||||||||:.||||.|||.:...||  .:|..|||:|:|||||   ::|.|..|.
Frog   132 LTKYSTIVLDEAHERSLSTDILFGLLKKQFQLRSFKRRKYPLKVIVMSATLESQKLSSFFGNC-- 194

  Fly   430 FKIPPPLLKVEARQFPVTIHFQK----RTPDD--YVAEAYRKTLKIHNKLPEGGILIFVTGQQEV 488
                 |::.:..:.||:...|..    |..|.  ||.|..:.||:.|...|||.||:|:|||.|:
Frog   195 -----PVVTIPGKVFPIKERFLNLIGPRDKDSTAYVTETVKITLQTHLNEPEGDILVFLTGQAEI 254

  Fly   489 NQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKK 553
            .:
Frog   255 ER--------------------------------------------------------------- 256

  Fly   554 KFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLW 618
                     ..||...|..|.|...|::     |...||                        |.
Frog   257 ---------ACNLLFKKAEGIDYRHDVY-----DRSVEG------------------------LL 283

  Fly   619 VLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSA 683
            :||||..:.:::|.|||:|.|.|.|.||:|||:|.||:||..|:||:|.|..|...|:...|:..
Frog   284 ILPLYGSMPTDQQKRIFVPPPSGIRKCVLSTNIAATSVTIEGIRYVIDSGFVKQLNYNPRAGLDI 348

  Fly   684 FVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGID 748
            ..:...||:.|.||||||||.:.|.|:|:||...::.|..|...|||::..:..::|.::|:.|.
Frog   349 LEIVPISKSEAVQRAGRAGRTAPGKCFRIYSEEFWDKCMPDHMIPDIKRTSLASVILTLKCLDIH 413

  Fly   749 RVVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFG----K 809
            .|:.||:...|::..:..|.::|....|:        |....||:|||.|..||::|...    |
Frog   414 DVIRFPYLDQPEERHILEALKKLYQCSAI--------DRTGCVTKLGHFIIEFPLSPNLACAVIK 470

  Fly   810 MLALSHQQNLLPYTVCLVAALSVQEVLIETG-VQRDEDVAPGANRFHRKRQSWAASGNYQLLGDP 873
            ..:...:..|||    :.|.|||:.|.|::| .|:.::...|    |.:....|...|     |.
Frog   471 ATSFGCEDLLLP----VAAMLSVEHVFIQSGQSQKQKEAGLG----HEELSQLAGGCN-----DF 522

  Fly   874 MVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMS---EVRKLRVQLTNEINLNVS-DVELGVDPE 934
            ..||...   |...:..:...:|..||:..:|:.   .|.|...::||.:..|.. .||....|
Frog   523 ATLLYIF---EQCKASPKPASWCHENGIHWRALKSALNVEKQLKEITNRLKQNKDFPVEKFDGP- 583

  Fly   935 LKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSVL-- 997
                   :...||:.|.||....|||:.........:....:.:            :|.||.|
Frog   584 -------RNEMLRRCLCAGYFSNVARRSVGRTFCTMDGHGSMIH------------IHPSSALFG 629

  Fly   998 RQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVPLLCNIREVREDPAPRFDKTSGKI 1062
            ::...||:::.....     ::|:|:|.:..|..||:...:|.|.:|.........|.:.|:.:|
Frog   630 KESELEWILFHNVLV-----TSKIFVRTVCPIRYEWVKDLLPKLHDIDAYELSNVAREEVTAEEI 689

Fly 1063 1062
Frog 690 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	251/839 (30%)
		DEXDc	279..418	CDD:238005	80/141 (57%)
		P-loop_NTPase	369..>500	CDD:304359	57/141 (40%)
		HELICc	619..704	CDD:197757	40/84 (48%)
		HA2	774..859	CDD:214852	25/89 (28%)
		OB_NTP_bind	915..1039	CDD:285018	26/126 (21%)
dhx40	NP_001184155.2	HrpA	1..700	CDD:224557	253/845 (30%)
		DEXDc	40..182	CDD:238005	80/141 (57%)
		HELICc	281..368	CDD:197757	41/110 (37%)
		HA2	441..526	CDD:214852	28/105 (27%)
		OB_NTP_bind	560..668	CDD:285018	28/132 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010