DRSC/TRiP Functional Genomics Resources

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Protein Alignment kz and Dhx36

DIOPT Version :9

Sequence 1:NP_001284815.1 Gene:kz / 31205 FlyBaseID:FBgn0001330 Length:1192 Species:Drosophila melanogaster
Sequence 2:NP_082412.2 Gene:Dhx36 / 72162 MGIID:1919412 Length:1001 Species:Mus musculus


Alignment Length:1090 Identity:255/1090 - (23%)
Similarity:455/1090 - (41%) Gaps:279/1090 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 SKKQRKHLQAIVDKKKKKEGRAQLLGDLAAVQIPEEELQQYTSISQVQTVGLKRLPTLDEYLAK- 133
            :|||         .:|.||...|   :.|.|.:.|...:|...:             |:...|| 
Mouse    60 AKKQ---------TQKNKEAERQ---ERAVVHMDERREEQIVQL-------------LNSVQAKT 99

  Fly   134 KKERQAQV--LAEKSSASGLRVNAIK--GSKRKLLVEEEEELQAKRKNPNVISVEEDDEDSSSSD 194
            .|:.:||:  .|.:....|..|::.|  .|::||..:|::.|..::|...:       .|.|..|
Mouse   100 DKDSEAQISWFAPEDHGYGTEVSSEKKINSEKKLDNQEKKLLNQEKKTFRI-------TDKSYID 157

  Fly   195 EDDEEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRTTEVQNARLR 259
            .|.|....::.|       :::..|..:: .:::.|.:|               |..|:|..|.:
Mouse   158 RDSEYLLQENEP-------NLSLDQHLLE-DLQRKKTDP---------------RYIEMQRFRKK 199

  Fly   260 LPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFL----YEAGYAQHKMIGVTEPRRVAAIA 320
            ||....:::::..||.:.:.:::||||.|||||:.||:    .|.|......|..|:|||::||:
Mouse   200 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAIS 264

  Fly   321 MSKRVAHEMNLPES-----EVSYLIRFEGNVTPATR--IKFMTDGVLLKEIETDFLLSKYSVIIL 378
            :::|||.|.  .||     ...|.||.:..: |..:  |.:.|.|::|:.:::|..||..|.|:|
Mouse   265 VAERVATER--AESCGNGNSTGYQIRLQSRL-PRKQGSILYCTTGIILQWLQSDSRLSSVSHIVL 326

  Fly   379 DEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTE---NTRLFKIPPPLLKVE 440
            ||.|||::.:|:|:.::..::..|    ..||:|:|||||....|:|   |.       |::.:.
Mouse   327 DEIHERNLQSDVLMTVIKDLLHFR----SDLKVILMSATLNAEKFSEYFGNC-------PMIHIP 380

  Fly   441 ARQFPVTIHFQKRTPDDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAP 505
            ...|||.         :|:.|...:.::            :|..|:|              |.:.
Mouse   381 GFTFPVV---------EYLLEDIIEKIR------------YVPDQKE--------------HRSQ 410

  Fly   506 TKDVAKNGKVSEEEKEET-----------IDD-----AASTVEDPKELEFDMKRVIRNIRKSKKK 554
            .|.....|.|:.:||||.           |.:     :||||:..:.::.|  :|..|:..:..:
Mouse   411 FKRGFMQGHVNRQEKEEKEAIYKERWPAYIKELRTRYSASTVDVLQMMDDD--KVDLNLIAALIR 473

  Fly   555 FLAQMALPKINLDD----YKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQ 615
            ::.      :..:|    ..|||.|..:.:|   |....|...:.|.                  
Mouse   474 YIV------LEEEDGAILVFLPGWDNISTLH---DLLMSQVMFKSDK------------------ 511

  Fly   616 PLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTG 680
             ..::||:||:.:..|.::|...|.|.|..|::||:||||:||..:.||:|.|:.|...:|....
Mouse   512 -FLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNN 575

  Fly   681 VSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCM 745
            :|.....:.|||:|.||.|||||:..||||.|| :.:.....:|:..|:|.:.|:|:|.||::.:
Mouse   576 ISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLY-NGLRASLLDDYQLPEILRTPLEELCLQIKIL 639

  Fly   746 GIDRVVHF--PFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFG 808
            .:..:.:|  ....||....:..:.:.|:.|.||:  |.|.      :|.||..::|.||.|..|
Mouse   640 RLGGIAYFLSRLMDPPSNEAVVLSIKHLMELSALD--KQEE------LTPLGVHLARLPVEPHIG 696

  Fly   809 KMLALSHQQNLLPYTVCLVAALSVQE-VLIETGVQRDEDVAPGANRFHRKRQSWAASGNYQLLGD 872
            ||:........|...:.:.|:||.:: .:|..|.::..|.         :|:..|.    :...|
Mouse   697 KMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADA---------RRKELAK----ETRSD 748

  Fly   873 PMVLLRAVGAAEYAGSQGRLPE--FCAANGLRQKAMSEVRKLRVQLTNEINLNVSDVELGV---- 931
            .:.::.|....|.|..:|...|  :|....|....:..:..::.|....:        ||.    
Mouse   749 HLTVVNAFEGWEEAKRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHL--------LGAGFVS 805

  Fly   932 -----DPELKPPTDAQARFLRQILLAGMGDRVA-------RKVPLADIADKEE------------ 972
                 ||:....:|.: :.::.::.||:..:||       :|..:..:..|.:            
Mouse   806 SRSPKDPKANINSDNE-KIIKAVICAGLYPKVAKIRLNLGKKRKMVKVHTKSDGLVSIHPKSVNV 869

  Fly   973 ----------------RRRLKYAYNCADMEEPAFLHVS---SVLRQK------APEWVIYQEAYE 1012
                            |....|.|:|.::.....|...   |:.:.|      ..||:::|....
Mouse   870 EQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCLLFFGGDISIQKDKDQEIIAVDEWIVFQSPER 934

  Fly  1013 LQNGDSTKMFIRGITAIEPEWLLLYVPLLCNIREVREDPAP-RFDKTSGK 1061
            :.:      .::|:.. |.:.||         :|..|.|.| .:|.|..:
Mouse   935 IAH------LVKGLRK-ELDSLL---------QEKIESPHPVDWDDTKSR 968

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kzNP_001284815.1 HrpA 237..1058 CDD:224557 218/913 (24%)
DEXDc 279..418 CDD:238005 54/149 (36%)
P-loop_NTPase 369..>500 CDD:304359 33/133 (25%)
HELICc 619..704 CDD:197757 35/84 (42%)
HA2 774..859 CDD:214852 22/85 (26%)
OB_NTP_bind 915..1039 CDD:285018 26/176 (15%)
Dhx36NP_082412.2 Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250|UniProtKB:Q9H2U1 1..193 37/187 (20%)
Required for the pre-miR-134 transport. /evidence=ECO:0000250|UniProtKB:D4A2Z8 1..97 12/61 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250|UniProtKB:Q9H2U1 1..44
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H2U1 46..98 12/62 (19%)
DSM (DHX36-specific motif). /evidence=ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q9H2U1 46..68 4/16 (25%)
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 99..379 90/323 (28%)
HrpA 188..894 CDD:224557 202/830 (24%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 258..310 17/54 (31%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 327..330 2/2 (100%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 380..621 76/306 (25%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 491..550 19/80 (24%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9H2U1 510..521 4/29 (14%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 622..691 20/76 (26%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 631..690 16/66 (24%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 834..898 8/63 (13%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 842..853 1/10 (10%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 863..893 2/29 (7%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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