Protein Alignment kz and Dhx35

DIOPT Version :10

• Sequence 1: NP_476591.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_001359442.1
• Gene: Dhx35 / 71715
• MGIID: 1918965
• Length: 703
• Species: Mus musculus
• Alignment Length: 844
• Identity: 257/844 - (30%)
• Similarity: 374/844 - (44%)
• Gaps: 197/844 - (23%)

  Fly   225 PIKKLKP-EPNPPACIHQ------------TVYVPVHRTTEVQNARLRLPILAEEQQVMETINEN 276
            |:|..|| ...|...|.:            .:|.| :....::..|.:||:......::..:...
Mouse     7 PVKFWKPGTEGPGVSISEERQSVTENSGTTIIYNP-YAALSIEQQRQKLPVFKLRNHILYLVENY 70

  Fly   277 PIVIVAGETGSGKTTQLPQFLYEAGY-AQHKMIGVTEPRRVAAIAMSKRVAHEMN-LPESEVSYL 339
            ..|::.||||.||:||:||:|.|||: |:.:::|||:||||||:.::.|||.|.. :...||.|.
Mouse    71 QTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVADERGAVLGHEVGYC 135

  Fly   340 IRFEGNVTP-ATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRH 403
            |||:....| ||||||:|||:|::|:..|.||:|||||:|||||||::||||.:|||.:|   :.
Mouse   136 IRFDDCTDPLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKI---QK 197

  Fly   404 KRGQPLKLIIMSATLRVSDFTENTRLFKIPPP------LLKVEARQFPVTIHFQKRTPDDYVAEA 462
            |||. |:||:.||||....|.:.....:...|      .|.||.|.|||.|.:.:....||:...
Mouse   198 KRGD-LRLIVASATLDAEKFRDFFNQNETSDPARDTSVTLTVEGRTFPVDIFYLQSPVPDYIKAT 261

  Fly   463 YRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDA 527
            ....:|||....:|.||.|:|||:||..:|..|                            |:.|
Mouse   262 VDTVVKIHQTEGDGDILAFLTGQEEVETVVSML----------------------------IEQA 298

  Fly   528 ASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEG 592
                                      :.||:
Mouse   299 --------------------------RALAR---------------------------------- 303

  Fly   593 LEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLT 657
                              :|.::.|.|||:|:.|.|.:|.::|..|....|..:|:|||||||:|
Mouse   304 ------------------TGMKKHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSIT 350

  Fly   658 IPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCF 722
            |..|.||:|||..|.|.|:..|.:...||...|:|||:|||||.||..:|.|||||:    .:.|
Mouse   351 ISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRNRSGKCYRLYT----EEAF 411

  Fly   723 EDFSQ---PDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGAL--EVAKT 782
            :...|   |::|:..:..::||::.:|||.|:.|.|.|||....:..|...|..||.|  :...|
Mouse   412 DQLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLT 476

  Fly   783 ENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRDEDV 847
            |         .||..|:.||:.|.|.|||..|.........:.:.|.:.:|.|.:....|:.:
Mouse   477 E---------PLGMRIAEFPLNPMFAKMLLESGNFGCSQEVLSIAAMMQIQNVFVFPSNQKSQ-- 530

  Fly   848 APGANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKL 912
               |.|.|||   :|...     ||.:.:|...   |......:..::|..:.|..|.:.....:
Mouse   531 ---ATRVHRK---FAVEE-----GDHLTMLNVY---EAFIKHNKSSQWCQEHFLNYKGLVRAATV 581

  Fly   913 RVQLTN-EINLNVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEERRRL 976
            |.||.. .:...|..|....||                      |.|.|.:.....|: ..|...
Mouse   582 RDQLKKLLVKFQVPKVSSEGDP----------------------DPVLRCIVSGFFAN-AARFHS 623

  Fly   977 KYAYNCADMEEPAFLHVSSVL-RQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVP 1039
            ..||.....:....:|.:||| .:|.|.||||.|..:     ::|.::|.:||||..|||...|
Mouse   624 SGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQ-----TSKYYMRDVTAIESAWLLELAP 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_476591.1	HrpA	260..>1071	CDD:441249	248/796 (31%)
		DEXHc_DHX37	260..439	CDD:350740	85/187 (45%)
Dhx35	NP_001359442.1	HrpA	54..>701	CDD:441249	248/796 (31%)