DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and Dhx34

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001258381.1	Gene:	Dhx34 / 684903	RGDID:	1584452	Length:	1143	Species:	Rattus norvegicus

Alignment Length:	789	Identity:	220/789 - (27%)
Similarity:	353/789 - (44%)	Gaps:	188/789 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 SSSDEDDEEAPAQSAPIAIPTPVSIAPP---QIAVKPPIKKLKPEPN---PPACIHQTVYVPVH- 248
            :|..|.|...|..........|.:..|.   .:::..|..:.:..|.   ||..:.:.....:|
  Rat    77 TSQKEKDPGQPKHGIAALADLPCTYDPRYRINLSILGPDTRGRHGPGKGLPPERVSEFRRALLHY 141

  Fly   249 ----------RTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYA 303
                      |..::|..|..|||.....::::|:.|:.:|:|||:||.||:||:||:|..||::
  Rat   142 LDFQQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFS 206

  Fly   304 QHKMIGVTEPRRVAAIAMSKRVAHE-MNLPESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETD 367
            .   :..|:|||:|.|:::|||..| ::...|:|.|.||||...:.||:|.|:|.|:||::|:.:
  Rat   207 H---VACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQCE 268

  Fly   368 FLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKI 432
            ..|.:|.|:|:||.|||.::.|.|:|:|.|::|.|    ..||:|:||||:.:|.|:.    :..
  Rat   269 PRLPQYQVLIVDEVHERHLHNDFLLGVLQRLLPQR----PDLKVILMSATINISLFSS----YFS 325

  Fly   433 PPPLLKVEARQFPVTIHFQKRTPDDYVAEA-------YRKTLK-IHNKLP---EGGILIFVTGQQ 486
            ..|:::|..|.||:|:.:|.:..:...:::       :.:.|: |.||.|   .|.:|:|::|..
  Rat   326 HAPVVQVPGRLFPITVVYQPQEAEQSASKSEKLDPRPFLRVLEAIDNKYPPEERGDLLVFLSGMA 390

  Fly   487 EVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKS 551
            |::                                 |:.|||.
  Rat   391 EIS---------------------------------TVLDAAQ---------------------- 400

  Fly   552 KKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQP 616
                 |...|.                                                  ||
  Rat   401 -----AYATLT--------------------------------------------------QR-- 408

  Fly   617 LW-VLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYD---K 677
             | ||||:|.||...|:::|...|.|.|.|::|||:||||:||..|::|||.|:.|...||   |
  Rat   409 -WVVLPLHSALSVADQDKVFDVAPAGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAK 472

  Fly   678 LTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQM 742
            |..:..|   :.|:|||:||.|||||...|.|||||:.:.| |.|..:..|:|::..::.|:|||
  Rat   473 LQRLQEF---WISQASAEQRKGRAGRTGPGVCYRLYAESDY-DAFAPYPVPEIRRVALDALVLQM 533

  Fly   743 RCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRF 807
            :.|.:.....|||..||....::.|...|...|||        |...|:|.:|.::::.||....
  Rat   534 KSMSVGDPRTFPFIEPPPAASVETAILYLQDQGAL--------DSSEALTPIGSLLAQLPVDVVI 590

  Fly   808 GKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRDEDVAPGANRFHRKRQSWAASGNYQLLGD 872
            |||:.|....:|....:.:.||||||.....: .|.:.|.|.........:            ||
  Rat   591 GKMMILGSMFSLAEPVLTIAAALSVQSPFTRS-AQSNLDCATARRPLESDQ------------GD 642

  Fly   873 PMVLLRAVGAAEYAGSQ--GRLPEFCAANGLRQKAMSEVRKLRVQLTNEINLNVSDVELGVDPEL 935
            |..|.....|.....|:  |...::|...|:.:..:.|:..||.|. .|:   :.|..|....::
  Rat   643 PFTLFNVFNAWVQVKSERSGNSRKWCRRRGVEEHRLYEMANLRRQF-KEL---LEDHGLLRGAQV 703

  Fly   936 KPPTDAQAR 944
            ..|.|:.:|
  Rat   704 VAPRDSYSR 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	210/737 (28%)
		DEXDc	279..418	CDD:238005	63/139 (45%)
		P-loop_NTPase	369..>500	CDD:304359	42/141 (30%)
		HELICc	619..704	CDD:197757	43/87 (49%)
		HA2	774..859	CDD:214852	23/84 (27%)
		OB_NTP_bind	915..1039	CDD:285018	7/30 (23%)
Dhx34	NP_001258381.1	HrpA	155..>687	CDD:224557	201/680 (30%)
Dhx34	NP_001258381.1	OB_NTP_bind	798..909	CDD:400182
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900