DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and Dqx1

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_038964267.1	Gene:	Dqx1 / 680434	RGDID:	1591766	Length:	780	Species:	Rattus norvegicus

Alignment Length:	958	Identity:	213/958 - (22%)
Similarity:	359/958 - (37%)	Gaps:	292/958 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 SSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIAVKP----PIKKLKPEPNPPACIHQTVYVPVHRT 250
            :|...|:.|.:|.:|              ::||.|    |..         :|.:
  Rat     2 ASGLAEESEPSPGES--------------ELAVNPFDGLPFS---------SCYY---------- 33

  Fly   251 TEVQNARLRLPILAEEQQVMETINENP--IVIVAGETGSGKTTQLPQFLYEAGYA---QHKMIGV 310
             |:...|..|||.|.....:|.:..:|  :|:|:||.||||:||:||:..|...|   |...:.|
  Rat    34 -ELLEQRRALPIWAARFLFLEHLESSPTGVVLVSGEPGSGKSTQIPQWCAEFALARGFQTGQVTV 97

  Fly   311 TEPRRVAAIAMSKRVAHEMNLP-ESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYS 374
            |:|..:||::::.|||.||:|. ..|:.|.|..|....|.|.::|..|.:.|:|:.:......:|
  Rat    98 TQPYPLAAMSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWS 162

  Fly   375 VIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATL--RVSDFTENTRLFKIPPPLL 437
            |::||||.||||.:|:|.||| |...||:..|.|..:|:..:.|  :...|..|:....:|.
  Rat   163 VLVLDEAQERSVASDLLQGLL-RDTRLRNLPGDPRVVIVTDSALEPKFQAFWGNSPTVHVPR--- 223

  Fly   438 KVEARQFPVTIHFQKRTPDDYVAEAYRKTLKI--HNKLPEGGILIFVTGQQEVNQLVRKLRRTFP 500
              |..:.| |:.::...|.|.|..|.:..|::  ..:.| |.:|:::..::|::.....|.|
  Rat   224 --EPGENP-TLTYKDTVPADLVEAACQAVLELCQREEAP-GDVLVYLPSEEEISLCCESLSR--- 281

  Fly   501 YHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKIN 565
                      :.|.::              |..|                          ||::
  Rat   282 ----------EMGMLA--------------VPGP--------------------------LPRV- 295

  Fly   566 LDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEK 630
                 ||       :|  |......:.:.||.|..:
  Rat   296 -----LP-------LH--PGCGQAIQTVYEDTDVSV----------------------------- 317

  Fly   631 QNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASAD 695
                        |..||:..:|:.|.::|.|::|:|.|.:...:|:......:.|:...||..|:
  Rat   318 ------------RKIVVTHWLADFSFSLPFIQHVIDSGLELRSVYNPRIRAESQVLRRISKCQAE 370

  Fly   696 QRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMR---------CMGIDRVV 751
            .|..||.....|.|.||||.:..:........|.:.::.:..|:|.::         |..:||
  Rat   371 ARLLRARGFPPGTCLRLYSKSTLDLEAPPLPHPKVCEENLSSLVLLLKRKQIAEPGECHFLDR-- 433

  Fly   752 HFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQ 816
                |:|  :..:||.| .|..|.||:    ::.||    :.||.::|.||:.|...|.|..|.:
  Rat   434 ----PAP--EALMQALE-DLDYLAALD----DDGDL----SDLGIILSEFPLPPELAKALLASCE 483

  Fly   817 QNLLPYTVCLVAALSVQEVLIETGVQRDEDVAPGANRFHRKRQSWAASGNYQLL-------GDPM 874
            .|.:...:.|.|.|:               .|||..|      ....:|...|.       ||..
  Rat   484 FNCVDEMLTLAAMLT---------------AAPGFTR------PPLCAGEAALRRGLEHADGDHS 527

  Fly   875 VLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLR---VQLTNEINLNVSDVELGVDPELK 936
            .|::...|...:|:.   ..:|.|.||..:|:.:.||||   ::|...|.|.:|....|.:...:
  Rat   528 SLIQVYEAFVQSGAD---ETWCQARGLSWEALCQARKLRAELLELMQRIELPLSLPAFGSEQNRR 589

  Fly   937 PPTDA--QARFLRQILLAGMGDRV----------ARKVPLADIADKE----ERRRLKYAYNCAD- 984
            ....|  ...||:.::..|:..::          .:..|||..:..:    ....|.:...||.
  Rat   590 DLQKALLSGYFLKAMMRRGLMSKLPSDSLSTSGWPQTAPLAPYSATQAGITATPALAFFIFCASL 654

  Fly   985 MEEPAFLHVSSVLRQ-------------------------------KAPEWVIYQEAYELQNGDS 1018
            :..|.:|..:.|.|.                               :.|.||:|.. :.:...:.
  Rat   655 LSPPMYLCFNEVARDTDGTGNYLLLTHKHVAQLSPYCVYRNRRTPAQPPTWVLYHR-FSISKDNC 718

  Fly  1019 TKMFIRGITAIEPEWLLLYVP--------------LLCNIREVREDPA 1052
                :..::.|:||.|:...|              ||..:||..|..|
  Rat   719 ----LCTVSEIQPEMLVELAPPYFLSNLPPSESRDLLNQLREGTEPSA 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	204/907 (22%)
		DEXDc	279..418	CDD:238005	57/142 (40%)
		P-loop_NTPase	369..>500	CDD:304359	39/134 (29%)
		HELICc	619..704	CDD:197757	18/84 (21%)
		HA2	774..859	CDD:214852	22/84 (26%)
		OB_NTP_bind	915..1039	CDD:285018	27/171 (16%)
Dqx1	XP_038964267.1	HrpA	15..>601	CDD:224557	181/777 (23%)
Dqx1	XP_038964267.1	OB_NTP_bind	662..737	CDD:400182	11/79 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910