DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kz and Dhx40

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_080467.3	Gene:	Dhx40 / 67487	MGIID:	1914737	Length:	779	Species:	Mus musculus

Alignment Length:	937	Identity:	256/937 - (27%)
Similarity:	395/937 - (42%)	Gaps:	259/937 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 RVNAIKGSKRKLLVEEEEELQAKRKNPNVISVEEDDEDSSSSDEDDEEAPAQSAPIAIPTPVSIA 216
            |..|:.|...:...|.|..::.:.:.|:.:.:.:.:|...:|.|..            .||.
Mouse     3 RFPAVAGRAPRRQEEGERPIELQEERPSAVRIADREEKGCTSQEGG------------TTPT--- 52

  Fly   217 PPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRTTEVQNARLRLPILAEEQQVMETINENPIVIV 281
                                                       .||..:.:::::.:.:|..:||
Mouse    53 -------------------------------------------FPIQKQRKKLIQAVRDNSFLIV 74

  Fly   282 AGETGSGKTTQLPQFLYEAGYAQHKMIGVTEPRRVAAIAMSKRVAHEMNLP-ESEVSYLIRFEGN 345
            .|.||||||||||::|||||::||.|||||:||:||||::::|||.||... .|:|.|.:||:..
Mouse    75 TGNTGSGKTTQLPKYLYEAGFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDC 139

  Fly   346 VTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRH-KRGQPL 409
            .:..|.||:||||.|||.|..|..|||:|||||||||||::.||||.|||.::...:. .|.:.|
Mouse   140 SSKETAIKYMTDGCLLKHILGDPNLSKFSVIILDEAHERTLTTDILFGLLKKLFQDKSPNRKEHL 204

  Fly   410 KLIIMSATL---RVSDFTENTRLFKIPPPLLKVEARQFPVTIHF------QKRTPDDYVAEAYRK 465
            |:::||||:   ::|.|..|..:|.||       .|.:||...|      :.|....|:....:.
Mouse   205 KVVVMSATMELAKLSAFFGNCPIFDIP-------GRLYPVREKFCNLIGPRDRENTAYIQAIVKV 262

  Fly   466 TLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAAST 530
            |:.||.....|.||:|:|||.|
Mouse   263 TMDIHLNEMAGDILVFLTGQFE------------------------------------------- 284

  Fly   531 VEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEE 595
            :|...||.|.|...:                      ||.....||..|
Mouse   285 IEKSCELLFQMAESV----------------------DYDYDVQDTTLD---------------- 311

  Fly   596 DNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPH 660
                                .|.:||.|..:::::|.|||||.|.|.|.||:|||::.|||||..
Mouse   312 --------------------GLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDG 356

  Fly   661 IKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDF 725
            |:||||.|..|...::...|:....|...||:.|.||:|||||.::|.|:|:||...::.|..|.
Mouse   357 IRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTASGKCFRIYSKEFWSQCMPDH 421

  Fly   726 SQPDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPA 790
            ..|:|::..:..::|.::|:.|..|:.||:..||::        |||:....::.:.:..|....
Mouse   422 VIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNE--------RLILEALKQLYQCDAIDRSGH 478

  Fly   791 VTRLGHVISRFPVAPRFG----KMLALSHQQNLLPYTVCLVAALSVQEVLI---ETGVQRDEDVA 848
            |||||..:..||:.|...    :..:|..:..|||    :.|.|||:.|.|   :...|::.:
Mouse   479 VTRLGLSMVEFPLPPHLTCAVIRAASLDCEDLLLP----IAAMLSVENVFIRPVDPEYQKEAE-- 537

  Fly   849 PGANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLR 913
                  .|.|:..|.:|.:.......|:.      |...|.|....:|..:.:..:.:....::.
Mouse   538 ------QRHRELAAKAGGFNDFATLAVIF------EQCKSSGAPASWCQKHWIHWRCLFSAFRVE 590

  Fly   914 VQLTNEINLNVSDVELGVDPELKPPTD--------AQARFLRQILLAGMGDRVARKVPLADIADK 970
            .||...|.            :||..:|        .:...||:.|.||....|||:.........
Mouse   591 AQLRELIR------------KLKQQSDFPRETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFCTM 643

  Fly   971 EERRRLKYAYNCADMEEPAFLHVSSVLRQKAP--EWVIYQEAYELQNGDSTKMFIRGITAIEPEW 1033
            :.|            ..|..:|.||.|.::..  ||:|:.|...     :||::.|.:..|..||
Mouse   644 DGR------------GSPVHIHPSSALHEQETKLEWIIFHEVLV-----TTKVYARIVCPIRYEW 691

  Fly  1034 LLLYVPLLCNI----------REVRED 1050
            :...:|.|..:          ||:|||
Mouse   692 VRDLLPKLHELNAHDLSSVARREMRED 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	245/852 (29%)
		DEXDc	279..418	CDD:238005	80/140 (57%)
		P-loop_NTPase	369..>500	CDD:304359	51/140 (36%)
		HELICc	619..704	CDD:197757	40/84 (48%)
		HA2	774..859	CDD:214852	21/91 (23%)
		OB_NTP_bind	915..1039	CDD:285018	30/133 (23%)
Dhx40	NP_080467.3	OB_NTP_bind	591..699	CDD:285018	31/136 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		11/107 (10%)
		DEXDc	48..236	CDD:214692	93/252 (37%)
		DEXDc	78..213	CDD:238005	77/134 (57%)
		DEAH box	173..176		2/2 (100%)
		HELICc	312..399	CDD:197757	40/86 (47%)
		HA2	469..557	CDD:214852	24/99 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820