DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kz and YTHDC2

DIOPT Version :9

Sequence 1:NP_001284815.1 Gene:kz / 31205 FlyBaseID:FBgn0001330 Length:1192 Species:Drosophila melanogaster
Sequence 2:XP_011541883.1 Gene:YTHDC2 / 64848 HGNCID:24721 Length:1439 Species:Homo sapiens


Alignment Length:1274 Identity:304/1274 - (23%)
Similarity:499/1274 - (39%) Gaps:360/1274 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 GRAQLLGDL-------AAVQI--------PEEELQQYTSISQVQTVGLKRLPT------------ 126
            |||:.|.|:       .||.|        .:.|::..:|::..:...:.||..            
Human    31 GRAKGLKDIRIDEEVKIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKG 95

  Fly   127 LDEYLAKKKERQAQVLAEKSSASGLRVNAIKGSKRKLLV------EEEEELQAKRKNPNVISVEE 185
            .:.||..||:..::. |.......|..|. |.:.|.|:.      :|..||..|.:..||.:||.
Human    96 ANRYLTVKKKDGSET-AHAMMTCNLTHNT-KHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEA 158

  Fly   186 DDEDSSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRT 250
            ::.:.|.:.                ..::...|||.||                        ...
Human   159 ENREMSKTS----------------GRLNNGIPQIPVK------------------------RGE 183

  Fly   251 TEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQHKMIGV----- 310
            :|..:.|..||:..:::::::.|.||.:|::.||||||||||:||||.:..:..    |:     
Human   184 SEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKN----GIPCRIF 244

  Fly   311 -TEPRRVAAIAMSKRVAHEMNLPESE-VSYLIRFEGNVTPATRIKFMTDGVLLKEIET-DFLLSK 372
             |:|||:||||:::|||.|......: :.|.||.|..|:|.|.:.|.|:||||:.:.. |..||.
Human   245 CTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLST 309

  Fly   373 YSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPPPLL 437
            .:.:|:||.|||..::|.   ||:::..|..|. ..||||:.||.|.|:.|   .|.|. ..|::
Human   310 VTHVIVDEVHERDRFSDF---LLTKLRDLLQKH-PTLKLILSSAALDVNLF---IRYFG-SCPVI 366

  Fly   438 KVEARQFPVTIHF-----------------------QKRTPDDYVAEAY--------------RK 465
            .::.|.|.|...|                       |:......:.|.|              |.
Human   367 YIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEEKQQTTLTEWYSAQENSFKPESQRQRT 431

  Fly   466 TLKI---HNKLPEGGILIF--VTGQQEVN----QLVRKLRRTFP--------------YHHAPTK 507
            .|.:   ::.|.:||..:|  :| :::||    .|::::.....              :|...|:
Human   432 VLNVTDEYDLLDDGGDAVFSQLT-EKDVNCLEPWLIKEMDACLSDIWLHKDIDAFAQVFHLILTE 495

  Fly   508 DVAKNGKVSEEEKEETIDDA----ASTVEDPKELEFDMKRVIRN--IRKSKKKFLAQMALPKI-- 564
            :|:.:.:.||......:..|    ||.||....:..::.....|  :.....|...|..:..:  
Human   496 NVSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLE 560

  Fly   565 ---------NLDDYKL---PGDDTEADMHE-----QPDEDDEQEGLE------------------ 594
                     |||:..|   .|.|..|:..|     ....|||:..|:                  
Human   561 SYSATLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAV 625

  Fly   595 ----EDNDDELGL------EDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVST 649
                ...|:.:||      :|:....|..|..:::  |:|.:.:..|.::....|.|.|..::||
Human   626 LIFLPGYDEIVGLRDRILFDDKRFADSTHRYQVFM--LHSNMQTSDQKKVLKNPPAGVRKIILST 688

  Fly   650 NVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYS 714
            |:||||:|:..:.:|:|.|:.|.:.:|.|..|:...:.:.|||||.||.|||||...|.|:||:|
Human   689 NIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFS 753

  Fly   715 SAVYNDCFEDFSQPDIQKKPVEDLMLQ------MRCMGIDRVVHFPFPSPPDQVQLQAAERRLIV 773
            ...:.:..| |..|::.:.|:::|.|.      :.|...|.::..|.|.|           .|||
Human   754 RLRFQNMLE-FQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEPPP-----------ALIV 806

  Fly   774 LGALEVAKT-ENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLI 837
            ..|:::.|| :..|....:|.||:.::..||.|..|||:            :|.|....:..:|.
Human   807 RNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMV------------LCAVVLKCLDPILT 859

  Fly   838 E--TGVQRDEDVAP------GANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPE 894
            .  |...||..|.|      .|....|||.:..|      ..|.|.||||..|.:.|.|.|....
Human   860 IACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGA------FSDHMALLRAFQAWQKARSDGWERA 918

  Fly   895 FCAANGLRQKAMSEVRKLRVQLTNEINL----------NVSDVELGVDPELKPPTDAQA-RFLRQ 948
            ||..|.|.|..|..:..:|.||..::..          ::.||.          |:::. ..::.
Human   919 FCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVN----------TNSENWAVVKA 973

  Fly   949 ILLAGMGDRVAR--KVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQ----KAP----- 1002
            .|:|||...:..  :..|.....||::.|               .|.:|||.|    |.|     
Human   974 ALVAGMYPNLVHVDRENLVLTGPKEKKVR---------------FHPASVLSQPQYKKIPPANGQ 1023

  Fly  1003 ---------EWVIYQE---AYELQNGDSTKMFIRGITAIEPEWLLLYV-PLLCNIREVREDPAPR 1054
                     :|:||.|   |:.:.|       ||..:|:.|..:|::. |.......::|..:.|
Human  1024 AAAIKALPTDWLIYDEMTRAHRIAN-------IRCCSAVTPVTILVFCGPARLASNALQEPSSFR 1081

  Fly  1055 FDKTSGKIFCHVDATFGKSGWELPLGEVEMPLSEKACCYFGM--------FLLDGEVCSRLADFR 1111
            .|                   .:|....:..:.:|.......        |.|:.|..|.|...|
Human  1082 VD-------------------GIPNDSSDSEMEDKTTANLAALKLDEWLHFTLEPEAASLLLQLR 1127

  Fly  1112 SKLKS-------TPASVIKSWSSMNNKVLRFKRALITKQ 1143
            .|..|       .|:   |.||.::...:|...|:::.:
Human  1128 QKWHSLFLRRMRAPS---KPWSQVDEATIRAIIAVLSTE 1163

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kzNP_001284815.1 HrpA 237..1058 CDD:224557 252/991 (25%)
DEXDc 279..418 CDD:238005 61/146 (42%)
P-loop_NTPase 369..>500 CDD:304359 42/176 (24%)
HELICc 619..704 CDD:197757 32/84 (38%)
HA2 774..859 CDD:214852 24/93 (26%)
OB_NTP_bind 915..1039 CDD:285018 31/158 (20%)
YTHDC2XP_011541883.1 R3H_DEXH_helicase 46..104 CDD:100077 9/57 (16%)
HrpA 189..>1016 CDD:224557 234/896 (26%)
DEXHc_YTHDC2 193..368 CDD:350745 72/186 (39%)
ANK repeat 505..537 CDD:293786 6/31 (19%)
ANK repeat 539..564 CDD:293786 3/24 (13%)
OB_NTP_bind 971..1066 CDD:369483 26/116 (22%)
YTH 1288..1404 CDD:367840
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.