DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and DHX37

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_005253647.1	Gene:	DHX37 / 57647	HGNCID:	17210	Length:	1175	Species:	Homo sapiens

Alignment Length:	1226	Identity:	545/1226 - (44%)
Similarity:	758/1226 - (61%)	Gaps:	140/1226 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGK--KVHNAKARQ--NPQTIVDNSAVKKIQI---DVDAVAGGNQVGYDEANALVLP-SEKRATK 57
            |||  :.:|.|.||  .|...........:|:   |.|.:.     |.|.:|||||| .:|:.||
Human     1 MGKLRRRYNIKGRQQAGPGPSKGPPEPPPVQLELEDKDTLK-----GVDASNALVLPGKKKKKTK 60

  Fly    58 IKVDKVQHVKILSKKQRKHLQAIVDKKKKKEGRAQLLGDLAAVQIPEEELQQYTSISQVQTVGLK 122
            ......:..|.|:||::|.||.|:::|:||..||::|..|:.||..|.|::.:.:.|::.| |.:
Human    61 APPLSKKEKKPLTKKEKKVLQKILEQKEKKSQRAEMLQKLSEVQASEAEMRLFYTTSKLGT-GNR 124

  Fly   123 RLPTLDEYLAKKKERQAQVLAEKSSASGLRVNAIKGSKRKLLVEEEEELQAKRKNPNVISVEEDD 187
            ...|        ||:..:|:|....    :::::.|:.||           :|:.|:....||::
Human   125 MYHT--------KEKADEVVAPGQE----KISSLSGAHRK-----------RRRWPSAEEEEEEE 166

  Fly   188 EDSSSS-------DEDDEEAPAQS-------------APIAIPTPVSI-APPQIAVKPPIKKLKP 231
            |:|.|.       |||....||::             ||.:.|.|..: .||..|..||:
Human   167 EESESELEEESELDEDPAAEPAEAGVGTTVAPLPPAPAPSSQPVPAGMTVPPPPAAAPPL----- 226

  Fly   232 EPNPPACIHQTVYVPVHRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQF 296
               |.|.....|::||:|:.|:|..||:||||:|||.:||.:.|:|||||.||||||||||:|||
Human   227 ---PRALAKPAVFIPVNRSPEMQEERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQF 288

  Fly   297 LYEAGY-AQHKMIGVTEPRRVAAIAMSKRVAHEMNLPESEVSYLIRFEGNVTPATRIKFMTDGVL 360
            |||||: ::..:|||||||||||:|||:|||.||||.:..|||.||:|||||..|||||||||||
Human   289 LYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSQRVVSYQIRYEGNVTEETRIKFMTDGVL 353

  Fly   361 LKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTE 425
            ||||:.||||.:|.|:|:|||||||||||||:|||||||.||.||..||||:||||||||.|||:
Human   354 LKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRNLPLKLLIMSATLRVEDFTQ 418

  Fly   426 NTRLFKIPPPLLKVEARQFPVTIHFQKRTP-DDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVN 489
            |.|||..|||::|||:||||||:||.|||| :||..|.:||..|||..||.||||:|:|||.||:
Human   419 NPRLFAKPPPVIKVESRQFPVTVHFNKRTPLEDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVH 483

  Fly   490 QLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSK-- 552
            .|.|:||:.||              .|....:|..||...:||:           :|..:||:
Human   484 ALCRRLRKAFP--------------PSRARPQEKDDDQKDSVEE-----------MRKFKKSRAR 523

  Fly   553 -KKFLAQMALPKINLDDYK-LPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQ 615
             ||..|:: ||:||||.|. ||..  |.|...:.:.|:|:..|:.|.|.:||   :.|...|::.
Human   524 AKKARAEV-LPQINLDHYSVLPAG--EGDEDREAEVDEEEGALDSDLDLDLG---DGGQDGGEQP 582

  Fly   616 ----PLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYD 676
                ||.||||||||:.|||.::|.|.|:|.|||||:|||||||||||.||||||||:.|.|.||
Human   583 DASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYD 647

  Fly   677 KLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQ 741
            ::||||:|.||:.|:||||||||||||...|||||||||||:.| ||.|..|:|.::|||||:||
Human   648 RVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGD-FEQFPPPEITRRPVEDLILQ 711

  Fly   742 MRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALE-------VAKTENTDLPPAVTRLGHVIS 799
            |:.:.:::|::||||:||....|.|||..||.||||:       |.:.:...|...:|.||..::
Human   712 MKALNVEKVINFPFPTPPSVEALLAAEELLIALGALQPPQKAERVKQLQENRLSCPITALGRTMA 776

  Fly   800 RFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVL--IETGVQRDEDVAPGANRFHRKR---- 858
            .||||||:.||||||.|...|||.:.:||:::|:|:.  ::.....||::    .|...||
Human   777 TFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEELDRPAASDEEL----TRLKSKRARVA 837

  Fly   859 ---QSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLTNEI 920
               ::||..|....|||.||||.||||.|||..   .|:||.|||||.|||.|:|:||.|||..:
Human   838 QMKRTWAGQGASLKLGDLMVLLGAVGACEYASC---TPQFCEANGLRYKAMMEIRRLRGQLTTAV 899

  Fly   921 NLNVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADM 985
            |....:.||.|||:::|||::|..:||||:.||:||.:||:|...::.:.:.|.    ||....:
Human   900 NAVCPEAELFVDPKMQPPTESQVTYLRQIVTAGLGDHLARRVQSEEMLEDKWRN----AYKTPLL 960

  Fly   986 EEPAFLHVSSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVPLLCNIREVRED 1050
            ::|.|:|.||||.::.||:|:|||..|     :|||:::|::::|.:|:...:|..|...:..|:
Human   961 DDPVFIHPSSVLFKELPEFVVYQEIVE-----TTKMYMKGVSSVEVQWIPALLPSYCQFDKPLEE 1020

  Fly  1051 PAPRFDKTSGKIFCHVDATFGKSGWELPLGEVEMPLSEKACCYFGMFLLDGEVCSRLADFRSKLK 1115
            |||.:....|::.||..:.|.:.||.||..||:.|.......:|..|||:|:|..:||.:||.|.
Human  1021 PAPTYCPERGRVLCHRASVFYRVGWPLPAIEVDFPEGIDRYKHFARFLLEGQVFRKLASYRSCLL 1085

  Fly  1116 STPASVIKSWSSMNNKVLRFKRALITKQIHNRQALIDQWNSDPHFLLEEYQNLLYD 1171
            |:|.:::|:|:.:..:.....|||:.::....:||:..|..:|....::.|.:..|
Human  1086 SSPGTMLKTWARLQPRTESLLRALVAEKADCHEALLAAWKKNPKCEFDQGQGVGVD 1141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	436/846 (52%)
		DEXDc	279..418	CDD:238005	106/139 (76%)
		P-loop_NTPase	369..>500	CDD:304359	90/131 (69%)
		HELICc	619..704	CDD:197757	62/84 (74%)
		HA2	774..859	CDD:214852	34/100 (34%)
		OB_NTP_bind	915..1039	CDD:285018	47/123 (38%)
DHX37	XP_005253647.1	HrpA	240..1016	CDD:224557	428/823 (52%)
		DEXDc	271..411	CDD:238005	106/139 (76%)
		P-loop_NTPase	<368..>511	CDD:304359	93/156 (60%)
		HELICc	585..674	CDD:197757	63/88 (72%)
		HA2	768..859	CDD:214852	36/94 (38%)
		OB_NTP_bind	894..1011	CDD:285018	48/125 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147721
Domainoid	1	1.000	226	1.000	Domainoid score	I2528
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6641
Inparanoid	1	1.050	932	1.000	Inparanoid score	I350
Isobase	1	0.950	-	0	Normalized mean entropy	S2229
OMA	1	1.010	-	-		QHG54789
OrthoDB	1	1.010	-	-		D203698at33208
OrthoFinder	1	1.000	-	-		FOG0005033
OrthoInspector	1	1.000	-	-		oto90703
orthoMCL	1	0.900	-	-		OOG6_102322
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1918
SonicParanoid	1	1.000	-	-		X3558
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750