Protein Alignment kz and DHX37

DIOPT Version :10

• Sequence 1: NP_476591.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: XP_005253647.1
• Gene: DHX37 / 57647
• HGNCID: 17210
• Length: 1175
• Species: Homo sapiens
• Alignment Length: 1226
• Identity: 545/1226 - (44%)
• Similarity: 758/1226 - (61%)
• Gaps: 140/1226 - (11%)

  Fly     1 MGK--KVHNAKARQ--NPQTIVDNSAVKKIQI---DVDAVAGGNQVGYDEANALVLP-SEKRATK 57
            |||  :.:|.|.||  .|...........:|:   |.|.:.     |.|.:|||||| .:|:.||
Human     1 MGKLRRRYNIKGRQQAGPGPSKGPPEPPPVQLELEDKDTLK-----GVDASNALVLPGKKKKKTK 60

  Fly    58 IKVDKVQHVKILSKKQRKHLQAIVDKKKKKEGRAQLLGDLAAVQIPEEELQQYTSISQVQTVGLK 122
            ......:..|.|:||::|.||.|:::|:||..||::|..|:.||..|.|::.:.:.|::.| |.:
Human    61 APPLSKKEKKPLTKKEKKVLQKILEQKEKKSQRAEMLQKLSEVQASEAEMRLFYTTSKLGT-GNR 124

  Fly   123 RLPTLDEYLAKKKERQAQVLAEKSSASGLRVNAIKGSKRKLLVEEEEELQAKRKNPNVISVEEDD 187
            ...|        ||:..:|:|....    :::::.|:.||           :|:.|:....||::
Human   125 MYHT--------KEKADEVVAPGQE----KISSLSGAHRK-----------RRRWPSAEEEEEEE 166

  Fly   188 EDSSSS-------DEDDEEAPAQS-------------APIAIPTPVSI-APPQIAVKPPIKKLKP 231
            |:|.|.       |||....||::             ||.:.|.|..: .||..|..||:
Human   167 EESESELEEESELDEDPAAEPAEAGVGTTVAPLPPAPAPSSQPVPAGMTVPPPPAAAPPL----- 226

  Fly   232 EPNPPACIHQTVYVPVHRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQF 296
               |.|.....|::||:|:.|:|..||:||||:|||.:||.:.|:|||||.||||||||||:|||
Human   227 ---PRALAKPAVFIPVNRSPEMQEERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQF 288

  Fly   297 LYEAGY-AQHKMIGVTEPRRVAAIAMSKRVAHEMNLPESEVSYLIRFEGNVTPATRIKFMTDGVL 360
            |||||: ::..:|||||||||||:|||:|||.||||.:..|||.||:|||||..|||||||||||
Human   289 LYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSQRVVSYQIRYEGNVTEETRIKFMTDGVL 353

  Fly   361 LKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTE 425
            ||||:.||||.:|.|:|:|||||||||||||:|||||||.||.||..||||:||||||||.|||:
Human   354 LKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRNLPLKLLIMSATLRVEDFTQ 418

  Fly   426 NTRLFKIPPPLLKVEARQFPVTIHFQKRTP-DDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVN 489
            |.|||..|||::|||:||||||:||.|||| :||..|.:||..|||..||.||||:|:|||.||:
Human   419 NPRLFAKPPPVIKVESRQFPVTVHFNKRTPLEDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVH 483

  Fly   490 QLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSK-- 552
            .|.|:||:.||              .|....:|..||...:||:           :|..:||:
Human   484 ALCRRLRKAFP--------------PSRARPQEKDDDQKDSVEE-----------MRKFKKSRAR 523

  Fly   553 -KKFLAQMALPKINLDDYK-LPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQ 615
             ||..|:: ||:||||.|. ||..  |.|...:.:.|:|:..|:.|.|.:||   :.|...|::.
Human   524 AKKARAEV-LPQINLDHYSVLPAG--EGDEDREAEVDEEEGALDSDLDLDLG---DGGQDGGEQP 582

  Fly   616 ----PLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYD 676
                ||.||||||||:.|||.::|.|.|:|.|||||:|||||||||||.||||||||:.|.|.||
Human   583 DASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYD 647

  Fly   677 KLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQ 741
            ::||||:|.||:.|:||||||||||||...|||||||||||:.| ||.|..|:|.::|||||:||
Human   648 RVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGD-FEQFPPPEITRRPVEDLILQ 711

  Fly   742 MRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALE-------VAKTENTDLPPAVTRLGHVIS 799
            |:.:.:::|::||||:||....|.|||..||.||||:       |.:.:...|...:|.||..::
Human   712 MKALNVEKVINFPFPTPPSVEALLAAEELLIALGALQPPQKAERVKQLQENRLSCPITALGRTMA 776

  Fly   800 RFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVL--IETGVQRDEDVAPGANRFHRKR---- 858
            .||||||:.||||||.|...|||.:.:||:::|:|:.  ::.....||::    .|...||
Human   777 TFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEELDRPAASDEEL----TRLKSKRARVA 837

  Fly   859 ---QSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLTNEI 920
               ::||..|....|||.||||.||||.|||..   .|:||.|||||.|||.|:|:||.|||..:
Human   838 QMKRTWAGQGASLKLGDLMVLLGAVGACEYASC---TPQFCEANGLRYKAMMEIRRLRGQLTTAV 899

  Fly   921 NLNVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADM 985
            |....:.||.|||:::|||::|..:||||:.||:||.:||:|...::.:.:.|.    ||....:
Human   900 NAVCPEAELFVDPKMQPPTESQVTYLRQIVTAGLGDHLARRVQSEEMLEDKWRN----AYKTPLL 960

  Fly   986 EEPAFLHVSSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVPLLCNIREVRED 1050
            ::|.|:|.||||.::.||:|:|||..|     :|||:::|::::|.:|:...:|..|...:..|:
Human   961 DDPVFIHPSSVLFKELPEFVVYQEIVE-----TTKMYMKGVSSVEVQWIPALLPSYCQFDKPLEE 1020

  Fly  1051 PAPRFDKTSGKIFCHVDATFGKSGWELPLGEVEMPLSEKACCYFGMFLLDGEVCSRLADFRSKLK 1115
            |||.:....|::.||..:.|.:.||.||..||:.|.......:|..|||:|:|..:||.:||.|.
Human  1021 PAPTYCPERGRVLCHRASVFYRVGWPLPAIEVDFPEGIDRYKHFARFLLEGQVFRKLASYRSCLL 1085

  Fly  1116 STPASVIKSWSSMNNKVLRFKRALITKQIHNRQALIDQWNSDPHFLLEEYQNLLYD 1171
            |:|.:::|:|:.:..:.....|||:.::....:||:..|..:|....::.|.:..|
Human  1086 SSPGTMLKTWARLQPRTESLLRALVAEKADCHEALLAAWKKNPKCEFDQGQGVGVD 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_476591.1	HrpA	260..>1071	CDD:441249	430/836 (51%)
		DEXHc_DHX37	260..439	CDD:350740	132/179 (74%)
DHX37	XP_005253647.1	HrpA	252..>1043	CDD:441249	431/838 (51%)