Protein Alignment kz and ythdc2

DIOPT Version :10

• Sequence 1: NP_476591.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: XP_021332046.1
• Gene: ythdc2 / 567114
• ZFINID: ZDB-GENE-220119-1
• Length: 1381
• Species: Danio rerio
• Alignment Length: 1128
• Identity: 271/1128 - (24%)
• Similarity: 447/1128 - (39%)
• Gaps: 324/1128 - (28%)

  Fly   104 EEELQQYTSISQVQTVGLKRLPTLDEYLAKKKERQAQVLAEKSSASGLRVNAIKGSKRKLLVEEE 168
            |:||...:|::..:...:.||              ||.|...|.:.|      ||..|.|.|.::
Zfish    51 EKELDFPSSLTNSERAFIHRL--------------AQSLGYISKSRG------KGCSRFLTVRKK 95

  Fly   169 EELQAKRKNPN----------VISVEEDDEDSS---SSDEDDEEAPAQSAPIAIPTP------VS 214
            :.::|:|.:.:          |.|:.:....||   |..:...|...||.|....:.      :|
Zfish    96 DGMEAQRSSMSCSLSPSCRALVQSLMQRFPISSRERSQLQPHAERGLQSPPDTTDSKSRTSGRLS 160

  Fly   215 IAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRTTEVQNARLRLPILAEEQQVMETINENPIV 279
            ...||:   ||.:...|                    |:...|..||:...::|::::|.::.:|
Zfish   161 HGIPQV---PPRRSSAP--------------------ELDAFRKALPVYELQEQIIQSIRDHQVV 202

  Fly   280 IVAGETGSGKTTQLPQFLYE--AGYAQHKMIGVTEPRRVAAIAMSKRVAHEM--NLPESEVSYLI 340
            :|.||||||||||:||||.:  :..|....|..|:|||:|.||:::|||.|.  |:.:: |.|.|
Zfish   203 LVLGETGSGKTTQIPQFLLDDCSATASPCRIFCTQPRRLATIAVAERVAAERGENIGQT-VGYQI 266

  Fly   341 RFEGNVTPATRIKFMTDGVLLKEIET-DFLLSKYSVIILDEAHERSVYTDILVGLLSRIV----- 399
            |.|..|:|.|.:.|.|.||||:.:.. |..||..:.:|:||.|||...||.|:..:..::
Zfish   267 RLESRVSPKTLLTFCTSGVLLRTLMAGDEALSTVTHVIVDEVHERDGLTDFLLTKMKEVLQKMPN 331

  Fly   400 ----------------------PLRHKRGQP--LKLIIMSATLRVSDFTENTRLFKIPPPLLKVE 440
                                  |:.|.:|.|  :|.:.:...||.:.:| |..:.|......|.|
Zfish   332 LRLVLSSAALDVSLFMRYFGSCPVIHIKGCPYEVKQLFLEDILRSTAYT-NKDMIKYKKEAQKEE 395

  Fly   441 ARQFPVTIHFQKRTPDDYVAEAYRKT---LKIHNKLPEGGILIF-VTGQQEVNQLVRKLRR---- 497
            ::|..::...::..|.....|  |.|   |:.:..|.:||..:| ...:::|:.|...|.|
Zfish   396 SQQCSLSEWCERDVPQADPPE--RPTVCVLQDNQLLDDGGDSVFSQMSEKDVSSLEPWLLREMDS 458

  Fly   498 --------------------------TFPYHHAPTKDV-----AKNGKVSEEE------------ 519
                                      :..|.|:.|...     |..|.||..|
Zfish   459 CISSIFLNQDADAFTQLFNLILNENISVDYRHSETSATALMVSAGRGFVSHTEQLLNMGANINIK 523

  Fly   520 ---------------KEETID--------------DAASTVEDPK-ELEFDMKRVIRNIRKSKKK 554
                           :.|.:|              |.||.:::.. ||..:.:.:::....|
Zfish   524 ASNGWTALDWAKHFKQTEAVDLLESHIWCAEASPQDEASLLQNSSCELSCEDQELLKAYHHS--- 585

  Fly   555 FLAQMALPKINLDDYKLPGDDTEADMH------EQPDED---------DEQEGLEEDNDDELGLE 604
                       .||.|:   |.:..:|      :..|:.         ||...|.    |::..:
Zfish   586 -----------FDDEKV---DLQLILHLLHSICQSSDQGAVLIFLPGYDEIVSLR----DQILFD 632

  Fly   605 DESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGR 669
            |:......||..::|  |:|.:.:..|.::....|.|.|..::|||:||||:|:..:.:|:|.|:
Zfish   633 DKRFTEHQQRFQVFV--LHSSMQTSDQKKVLKSTPKGVRKIILSTNIAETSITVSDVVFVIDSGK 695

  Fly   670 QKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKP 734
            .|.:.||.|..|:...:.:.|||||.||.|||||...|.|:.|:|...:::..| ...|.:.:.|
Zfish   696 VKEKAYDALNNVTMLKMVWISKASALQRKGRAGRCRPGVCFHLFSRLRFSNMLE-HQIPQLLRMP 759

  Fly   735 VEDLMLQMRCMGIDRVVHFPF-------PSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVT 792
            :::|.|..:.:.   .::.|.       |.||....::.|.:.|..:.|::  ..||      :|
Zfish   760 LQELCLHTKLLA---PINCPVAEFLSRAPEPPHINTVKHAVQMLKTIDAMD--PWEN------LT 813

  Fly   793 RLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIE--TGVQRDEDVAPGANRFH 855
            .||..::..||.|..|||:            :|.|....:..||..  |...|:..|.| |....
Zfish   814 ELGLHLADLPVEPHLGKMV------------LCAVVLKCLDPVLTIACTLAHREPFVLP-AQAAQ 865

  Fly   856 RK-----RQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQ 915
            |:     |:.:.|:    ...|.|.||||..|.:.|.|.|....||..|.|.|..|..:..:|.|
Zfish   866 RRVAMLCRRRFTAN----TFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIVSMRTQ 926

  Fly   916 LTNEINL----------NVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADK 970
            |..::..          ::.||.         ........::..|:|||...:..:..|:...:|
Zfish   927 LLGQLRATGFVRARGGGDIRDVN---------QNSENWAVVKAALVAGMYPNLIHRDGLSLSGEK 982

  Fly   971 EERRRLKYAYNCADMEEPAFLHVSSVLRQ----KAP--------------EWVIYQE---AYELQ 1014
            |::.|               ||.:|||.|    |.|              :|:||.|   |:.:.
Zfish   983 EKKVR---------------LHPTSVLSQPQYKKIPPANGQAAAVDSLPTDWLIYDEMTRAHRIA 1032

  Fly  1015 NGDSTKMFIRGITAIEPEWLLLY 1037
            :       :|..||:.|..:.|:
Zfish  1033 S-------VRCCTAVTPLTIALF 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_476591.1	HrpA	260..>1071	CDD:441249	236/953 (25%)
		DEXHc_DHX37	260..439	CDD:350740	70/212 (33%)
ythdc2	XP_021332046.1	R3H_DEXH_helicase	36..94	CDD:100077	16/62 (26%)
		PRK11131	169..>1003	CDD:182986	228/933 (24%)
		DEXHc_YTHDC2	183..358	CDD:350745	61/175 (35%)
		ANKYR	<473..>549	CDD:440430	10/75 (13%)
		ANK repeat	496..524	CDD:293786	5/27 (19%)
		SF2_C_RHA	584..739	CDD:350178	51/177 (29%)
		OB_NTP_bind	958..1050	CDD:400182	26/113 (23%)
		YTH	1249..1378	CDD:410979