Protein Alignment kz and spn-E

DIOPT Version :10

• Sequence 1: NP_476591.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Alignment Length: 1058
• Identity: 252/1058 - (23%)
• Similarity: 433/1058 - (40%)
• Gaps: 281/1058 - (26%)

  Fly   255 NARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQHKM--IGVTEPRRVA 317
            |....|.|.|:.::::..||.:|:||:.||||.|||||:||::.:..|...|.  |.||:|||:|
  Fly   110 NRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQPRRIA 174

  Fly   318 AIAMSKRVAHEMNLPESEV-SYLIRF-EGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDE 380
            ||:::.||..|....::.| |:.:.. ..|....||:.:.|.||||..:..:..|:.|:.|:|||
  Fly   175 AISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDE 239

  Fly   381 AHERSVYTDILVGLLSRIVPL--RHKRGQPLKLIIMSATL---RVSDFTENTRLFKIPPPLLKVE 440
            .|||....|.|:.::.|::..  ||     :|:|:||||:   .:||:...|.  .|||.:
  Fly   240 VHERDQNMDFLLIVVRRLLATNSRH-----VKIILMSATIDAKELSDYFTTTN--SIPPVI---- 293

  Fly   441 ARQFPVTIHFQKRTPDDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAP 505
                 .|.|.:|.:    :.:.||..|        |.|   :..:::|.             |..
  Fly   294 -----TTNHRRKHS----IEKFYRDQL--------GSI---IWNEEDVG-------------HQQ 325

  Fly   506 TKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMA----LPKINL 566
            ..::.|:|..:..:....||:            .:.|..|:: |:|..:.|...|    ||.|
  Fly   326 VPEINKHGYRAAVKIIVIIDN------------MERKAAIQS-RQSYDEALRYGAVLIFLPGI-- 375

  Fly   567 DDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQ 631
              |::   ||.|          |......:||..:.:.              ::..:||::.|.|
  Fly   376 --YEI---DTMA----------ENLTCMLENDPNIKVS--------------IVRCFSLMTPENQ 411

  Fly   632 NRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQ 696
            ..:|.|.|.|.|..:::||:||:|:|:|.:.||:|....|.::.|..:..|:..:|:.|||:..|
  Fly   412 RDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQ 476

  Fly   697 RAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVHF--PFPSPP 759
            ||||.||:.:|..||:.:...|.....:|..|::.:.|:::.:|:.:.:.:...|..  ...|||
  Fly   477 RAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPP 541

  Fly   760 DQVQLQAAERRLIVLGALEVAKTENTD-LPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYT 823
            :...:......|..:|||.:......| |...:|..|.::||.|:..|..:::.|.:..|:|...
  Fly   542 NLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEA 606

  Fly   824 VCLVAALSVQEVLIETGVQRDEDVAPGANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGS 888
            :.:.|.||                .||.         :|..|....|||...:       .|..|
  Fly   607 IIIAAGLS----------------TPGL---------FAHEGGRSQLGDSFWM-------HYIFS 639

  Fly   889 QGRLPEFCA------------ANGLRQK-AMSEVRKLRVQLTN--EINLNVSDV-----ELGVDP 933
            .|...:..|            .||..|: |:...::..|.|.:  ||:|.|.::     .||:.|
  Fly   640 DGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIP 704

  Fly   934 ELKPPT----DAQARFLRQILLAG----------------------------------------- 953
            ....|.    |.:...:.::::||
  Fly   705 FPVNPNQMMDDREKAIMLKVIIAGAFYPNYFTRSKESCADTDRNIYQTISGHDPCRTVYFTNFKP 769

  Fly   954 --MGDRVARKV-----------PLADIADKEERRRLKYAYNCADMEEPAFLHV------------ 993
              ||:...|::           ...|:..:|..:::...:...|..|.:..:|
  Fly   770 AYMGELYTRRIKELFQEVRIPPENMDVTFQEGSQKVFVTFKQDDWIEGSSKYVPVSGRVQSEVYK 834

  Fly   994 SSVLRQKAPEWVIYQEAYELQNGDSTKMFI--RGI-TAIEPEWLLLYVPLLCNIREVREDPAPRF 1055
            :.::||...|..|:     :.|..:...::  ||| ..||..|:....||  |: |:...|:. |
  Fly   835 AVMMRQNRVERPIH-----IMNPSAFMSYVQQRGIGDVIEGRWIPPTKPL--NV-ELLALPSV-F 890

  Fly  1056 DKT-SGKIFCHVDATFGKSGWELPLGEVEMPLSEKACCYFGMFLLDGEVCSRLADFRSKLKS--T 1117
            ||| ||.|.|.|:.  ||..::        |.|.:.|.         ...|.:.:...:|::  |
  Fly   891 DKTISGSITCIVNC--GKFFFQ--------PQSFEECI---------RNMSEIFNAPQQLRNYVT 936

  Fly  1118 PASVI-KSWSSMNNKVLRFKRALITKQIH--NRQAL-----IDQWNSD----------PHFLLEE 1164
            .||.| |....:..:...|:||.:.:..:  |||.:     ||..|..          |..|.|:
  Fly   937 NASAIAKGMMVLAKRDSYFQRATVIRPENQSNRQPMFYVRFIDYGNCTLLPMQLMRLMPRELTEQ 1001

  Fly  1165 YQNL---LYDVALSELTP 1179
            |.:|   :::..|:.:.|
  Fly  1002 YGDLPPRVFECRLAMVQP 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_476591.1	HrpA	260..>1071	CDD:441249	223/920 (24%)
		DEXHc_DHX37	260..439	CDD:350740	69/187 (37%)
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	183/702 (26%)
		DEXHc_TDRD9	115..295	CDD:350746	69/195 (35%)
		TUDOR	892..1016	CDD:425754	34/142 (24%)