Protein Alignment kz and mle

DIOPT Version :9

• Sequence 1: NP_001284815.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Alignment Length: 1048
• Identity: 245/1048 - (23%)
• Similarity: 424/1048 - (40%)
• Gaps: 262/1048 - (25%)

  Fly    60 VDKVQHVKILSKKQRKHLQAIVDKKKKKEGRAQLLG----------DLAAVQIPEEELQQYTSIS 114
            :|::|..:.:::.:...:.|.:......|...:.|.          |.....:..|..:.:.:..
  Fly   140 IDRIQEQRDMNEAEAFDVNAAIHGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAEL 204

  Fly   115 QVQTVGLKRLPTLDEYLAKKKERQAQVLAEKSSASGL-----RVNAIKGSKRKLLVEEEEELQ-- 172
            .:....|.|..|..|..:.||.      |.||.|..|     .:|.|:.....|..:::|:|:
  Fly   205 SIYVPALNRTVTARESGSNKKS------ASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPY 263

  Fly   173 AKRKNPNVISVEEDDEDSSSSDEDDEEAPAQSAPIAIPTPVSI---APP--------------QI 220
            ..:.:||:|            ::.||.......|:..|..:.|   .||              |.
  Fly   264 PVKLSPNLI------------NKIDEVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQD 316

  Fly   221 AVKPPIKKLKPEPNPP-------ACIHQTVYVPVHRTTEVQNA---------------------- 256
            ..|.....:.|...|.       ||   .:......||.:.:.
  Fly   317 GEKRQESSVIPWAPPQANWNTWHAC---NIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFL 378

  Fly   257 --RLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLY-------EAGYAQHKMIGVTE 312
              |.:|||.|...:::..||:||:||:.|.||.|||||:.|::.       :.|||.   |.||:
  Fly   379 EFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYAN---IYVTQ 440

  Fly   313 PRRVAAIAMSKRVAHEM--NLPESEVSYLIRFEGNV-TPATRIKFMTDGVLLKEIETDFLLSKYS 374
            |||::||::::|||.|.  .|.:: |.|.:|||... .|...|.|.|.||||:::|..  |...|
  Fly   441 PRRISAISVAERVARERCEQLGDT-VGYSVRFESVFPRPYGAILFCTVGVLLRKLEAG--LRGVS 502

  Fly   375 VIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPPPLLKV 439
            .||:||.|||.|.:|.|:.:|..:|...    ..|.:|:||||:   |.|:.::.|.| .|:|:|
  Fly   503 HIIVDEIHERDVNSDFLLVILRDMVDTY----PDLHVILMSATI---DTTKFSKYFGI-CPVLEV 559

  Fly   440 EARQFPVTIHFQKR--TPDDYV--AEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFP 500
            ..|.|||...|.:.  ...|:|  ||:.||..::.:   |..:|.....:.|:|.
  Fly   560 PGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVED---EEQLLSEDKDEAEINY---------- 611

  Fly   501 YHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVI------RNIRKSKKKFLAQ- 558
                        .||.|::..:...:|.:.:.: .::.|::...:      :||..:...||..
  Fly   612 ------------NKVCEDKYSQKTRNAMAMLSE-SDVSFELLEALLMHIKSKNIPGAILVFLPGW 663

  Fly   559 ---MALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVL 620
               .||.|. |.:..:.||.::..                                       :|
  Fly   664 NLIFALMKF-LQNTNIFGDTSQYQ---------------------------------------IL 688

  Fly   621 PLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFV 685
            |.:|.:..::|.::|.|||:|....::|||:||||:||..|.:|:|..:.:.:|:.....::::.
  Fly   689 PCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYA 753

  Fly   686 VTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRV 750
            ..:.||.:.:||.|||||:..|.|:.|.|.|.: ...||...|::.:.|:.::.|.::.:.:..:
  Fly   754 TVWASKTNLEQRKGRAGRVRPGFCFTLCSRARF-QALEDNLTPEMFRTPLHEMALTIKLLRLGSI 817

  Fly   751 VHFPF----PSPPDQV-QLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKM 810
            .||..    |.|.|.| :.:...|.:..|.|       |.:|.|    ||.:::|.|:.||.|||
  Fly   818 HHFLSKALEPPPVDAVIEAEVLLREMRCLDA-------NDELTP----LGRLLARLPIEPRLGKM 871

  Fly   811 LALSHQQNLLPYTVCLVAALSV-QEVL-IETGVQRDEDVAPGANRFHRKRQSWAASGNYQLLGDP 873
            :.|............:.:..|. .||. ::.|.:|      .||  |:|..|.....::.    .
  Fly   872 MVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRR------LAN--HQKALSGTKCSDHV----A 924

  Fly   874 MVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLTNEINLNVSDVELGVDPELKPP 938
            |::...:...|....:.....||...||:...|:.:...:.||.:.:.
  Fly   925 MIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQ----------------- 972

  Fly   939 TDAQARFLRQILLA-GMGDRVARKVPLADIA--------------DKEERRRLKYAYNCADMEEP 988
               ||.|..:.::: .:.:|:....|:.|::              .||:|:.|      ....:.
  Fly   973 ---QAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVL------TTESKA 1028

  Fly   989 AFLHVSSV 996
            |.||.:||
  Fly  1029 ALLHKTSV 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	208/830 (25%)
		DEXDc	279..418	CDD:238005	60/148 (41%)
		P-loop_NTPase	369..>500	CDD:304359	42/134 (31%)
		HELICc	619..704	CDD:197757	30/84 (36%)
		HA2	774..859	CDD:214852	24/86 (28%)
		OB_NTP_bind	915..1039	CDD:285018	17/97 (18%)
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	14/75 (19%)
		DEXDc	393..569	CDD:214692	76/189 (40%)
		DEXDc	402..542	CDD:238005	60/149 (40%)
		ATP-synt_B	<584..644	CDD:304375	13/85 (15%)
		Helicase_C	643..772	CDD:278689	40/168 (24%)
		HA2	842..926	CDD:214852	25/106 (24%)
		OB_NTP_bind	974..1078	CDD:285018	14/69 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468058
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840