DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and Rhau

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001260639.1	Gene:	Rhau / 35339	FlyBaseID:	FBgn0032883	Length:	942	Species:	Drosophila melanogaster

Alignment Length:	853	Identity:	222/853 - (26%)
Similarity:	363/853 - (42%)	Gaps:	199/853 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 ARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYE----AGYAQHKMIGVTEPRRV 316
            ||.:||.:.....:::.:.||.::::.|.||.|||||:||.|.:    .|.|....|..|:|||:
  Fly   149 ARKKLPTMKYADDIIQAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCASSCRIICTQPRRI 213

  Fly   317 AAIAMSKRVAHEM--NLPESEVSYLIRFEG-NVTPATRIKFMTDGVLLKEIETDFLLSKYSVIIL 378
            :|||:::.|::|.  :|..| |.|.||.|. .......|.:.|.||||:::::|.|:...||:||
  Fly   214 SAIAIAEWVSYERCESLGNS-VGYQIRLESRKARERASITYCTTGVLLQQLQSDPLMHNLSVLIL 277

  Fly   379 DEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTE---NTRLFKIPPPLLKVE 440
            ||.|||||.||:|:|||..|:|.|    ..||:|:||||:|..||.:   |.       |:.::|
  Fly   278 DEIHERSVETDLLMGLLKVILPHR----PDLKVILMSATVREQDFCDYFNNC-------PMFRIE 331

  Fly   441 ARQFPVTIHFQKRTPDDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAP 505
            ...|||.:.        |:.:...||                      |...:|.|...|....|
  Fly   332 GVMFPVKML--------YLEDVLSKT----------------------NYEFQKFRDRRPKRDPP 366

  Fly   506 TKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYK 570
            .:.:          |.|.:                ::..:|.||.|....:         ||..:
  Fly   367 ERRM----------KHEAM----------------IEPYLRRIRNSYDSRV---------LDKLR 396

  Fly   571 LPGDDTEADMHEQPDEDDEQEGLEE------------DNDDE----------------LGLEDES 607
            ||                |.||.|:            :|:.|                ..:.|:.
  Fly   397 LP----------------ESEGCEDIDFIADLVYYICENEPEGAILVFLPGYDKISQLYNILDKP 445

  Fly   608 GMGSGQRQPLW-----VLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDC 667
            ....|||   |     |.||:||:.|.:|..:|...|.|.|..::||.:||||:||..:.||::.
  Fly   446 KTSKGQR---WRDHMAVFPLHSLMQSGEQQAVFRRPPAGQRKVIISTIIAETSVTIDDVVYVINS 507

  Fly   668 GRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQK 732
            ||.|...||..|.:.:....:.:||:..||.|||||:..|.||.|:|.| ..|..:|...|:|.:
  Fly   508 GRTKATNYDIETNIQSLDEVWVTKANTQQRRGRAGRVRPGICYNLFSRA-REDRMDDIPTPEILR 571

  Fly   733 KPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHV 797
            ..:|.::|.::.:.||....|.      |..:.|.....|.:|...:.:.|..|....:|.||..
  Fly   572 SKLESIILSLKLLHIDDPYRFL------QTLINAPNPEAIKMGVELLKRIEALDQTGTLTPLGMH 630

  Fly   798 ISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRDEDVAPGANRFHRKRQSWA 862
            :::.|:.|:.|||:.:|.....|.......||||.:.... :.:.::..|.....|..|..:|
  Fly   631 LAKLPIDPQMGKMILMSALFCCLDPITSAAAALSFKSPFY-SPLGKESRVDEIKRRMARNMRS-- 692

  Fly   863 ASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLTNEI------- 920
               ::.::.:.::..|   .:.|:.::   .:||..|.|....:.::.:::.|.:..:
  Fly   693 ---DHLMVHNTIIAYR---DSRYSHAE---RDFCYKNFLSSMTLQQLERMKNQFSELLYNYKFLA 748

  Fly   921 NLNVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRVA--RKVPLADIADKEERRRLKYAYNCA 983
            :.|..|.....:.|..|       .||.|:.||:...:|  ||       .::.:.|::..:..|
  Fly   749 SSNCKDAASNKNSEKIP-------LLRAIIGAGLYPNMAHLRK-------SRQIKNRVRAIHTMA 799

  Fly   984 -DMEEPAFLHVSSVLRQKAPEWVIYQEAY--ELQNGDSTKMFIRGITAIEPEWLLLY-------- 1037
             |.......|.|||...::.    :..||  ..|...||.:|:...|.:.|..|:::
  Fly   800 TDDGRRVNFHPSSVNSGESG----FDSAYFVYFQRQKSTDLFLLDSTMVFPMALIIFGDGVEAGV 860

  Fly  1038 ---VPLLC 1042
               .|.||
  Fly   861 TQNTPYLC 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	222/853 (26%)
		DEXDc	279..418	CDD:238005	64/145 (44%)
		P-loop_NTPase	369..>500	CDD:304359	43/133 (32%)
		HELICc	619..704	CDD:197757	35/84 (42%)
		HA2	774..859	CDD:214852	20/84 (24%)
		OB_NTP_bind	915..1039	CDD:285018	29/146 (20%)
Rhau	NP_001260639.1	DEXDc	147..328	CDD:214692	76/190 (40%)
		DEXDc	170..312	CDD:238005	63/146 (43%)
		Helicase_C	411..544	CDD:278689	42/135 (31%)
		HA2	614..696	CDD:214852	20/87 (23%)
		OB_NTP_bind	735..853	CDD:285018	29/135 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468054
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840