DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and Ythdc2

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_038953178.1	Gene:	Ythdc2 / 307446	RGDID:	1563192	Length:	1434	Species:	Rattus norvegicus

Alignment Length:	1277	Identity:	299/1277 - (23%)
Similarity:	483/1277 - (37%)	Gaps:	366/1277 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 GRAQLLGDL-------AAVQI--------PEEELQQYTSISQVQTVGLKRLPT------------ 126
            |||:.|.|:       .||.|        .:.|::..:|::..:...:.||..
  Rat    35 GRAKGLKDIRIDEEVKIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKG 99

  Fly   127 LDEYLAKKKERQAQVLAEKSSASGLRVNAIKGSKRKLLV------EEEEELQAKRKNPNVISVE- 184
            .:.||..||:..::. |.......|..|. |.:.|.|:.      :|..||..|.:..||.:||
  Rat   100 ANRYLTVKKKDGSET-AHAMMTCNLTHNT-KHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEA 162

  Fly   185 EDDEDSSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHR 249
            |:.|.|.:|...:...|                                          .|||.|
  Rat   163 ENREMSKTSGRLNNGIP------------------------------------------QVPVKR 185

  Fly   250 -TTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQHKMIGV--- 310
             .:|..:.|..||:..:::::::.|.||.:|::.||||||||||:||||.:..:..    |:
  Rat   186 GESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKN----GIPCR 246

  Fly   311 ---TEPRRVAAIAMSKRVAHEMNLPESE-VSYLIRFEGNVTPATRIKFMTDGVLLKEIET-DFLL 370
               |:|||:||||:::|||.|......: :.|.||.|..|:|.|.:.|.|:||||:.:.. |..|
  Rat   247 IFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTL 311

  Fly   371 SKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPPP 435
            |..:.:|:||.|||..::|.   ||:::..|..|. ..||||:.||.|.|:.|   .|.|. ..|
  Rat   312 STVTHVIVDEVHERDRFSDF---LLTKLRDLLQKH-PTLKLILSSAALDVNLF---IRYFG-SCP 368

  Fly   436 LLKVEARQFPVTIHF--------------------------------------QKRT--PDDYVA 460
            ::.::.|.|.|...|                                      |:.|  |:....
  Rat   369 VIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQ 433

  Fly   461 EAYRKTLKIHNKLPEGGILIF-------------------------------VTGQQEVNQLVRK 494
            .|.....:.::.|.:||..:|                               |....:|..|:..
  Rat   434 RAVASVSEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILT 498

  Fly   495 LRRTFPYHHAPTKDVA---KNGKVSEEEKEETIDDAASTVEDPKE--------LEFDMKRVIRNI 548
            ...:..|.|:.|...|   ..|:....:.|:.|...|:.......        ..|....::..:
  Rat   499 ENVSVDYRHSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLL 563

  Fly   549 RKSKKKFLAQMALPKINLDDYKL---PGDDTEADMHE-----QPDEDDEQEGLE----------- 594
                :.:.|.:...  |||:..|   .|:|..|:..|     ....|||:..|:
  Rat   564 ----ESYSASLEFG--NLDESSLVQTNGNDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICH 622

  Fly   595 -----------EDNDDELGLED----ESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRL 644
                       ...|:.:||.|    :....:.......|..|:|.:.:..|.::....|.|.|.
  Rat   623 SCDAGAILIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRK 687

  Fly   645 CVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHC 709
            .::|||:||||:|:..:.:|:|.|:.|.:.:|.|..|:...:.:.|||||.||.|||||...|.|
  Rat   688 IILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGIC 752

  Fly   710 YRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQ------MRCMGIDRVVHFPFPSPPDQVQLQAAE 768
            :||:|...:.:..| |..|::.:.|:::|.|.      :.|...|.::..|.|.|
  Rat   753 FRLFSRLRFQNMLE-FQTPELLRMPLQELCLHTKLLAPVNCTIADFLMKAPEPPP---------- 806

  Fly   769 RRLIVLGALEVAKT-ENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSV 832
             .|||..|:::.|| :..|....:|.||:.::..||.|..|||:            :|.|....:
  Rat   807 -ALIVRNAVQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMV------------LCAVVLKCL 858

  Fly   833 QEVLIE--TGVQRDEDVAP------GANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQ 889
            ..:|..  |...||..|.|      .|....|||   ..:|.:   .|.|.||||..|.:.|.|.
  Rat   859 DPILTIACTLAYRDPFVLPTQASQKRAAMLCRKR---FTAGTF---SDHMALLRAFQAWQKARSD 917

  Fly   890 GRLPEFCAANGLRQKAMSEVRKLRVQLTNEINL----------NVSDVELGVDPELKPPTDAQA- 943
            |....||..|.|.|..|..:..:|.||..::..          ::.||.          |:::.
  Rat   918 GWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVN----------TNSENW 972

  Fly   944 RFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQ----KAP-- 1002
            ..::..|:|||...:..       .|:|.      .......|:....|.:|||.|    |.|
  Rat   973 AVVKAALVAGMYPNLVH-------VDREN------VVLTGPKEKKVRFHPTSVLSQPQYKKIPPA 1024

  Fly  1003 ------------EWVIYQE---AYELQNGDSTKMFIRGITAIEPEWLLLYV-PLLCNIREVREDP 1051
                        :|:||.|   |:.:.|       ||..:|:.|..:|::. |.......::|..
  Rat  1025 NGQAAAIQALPTDWLIYDEMTRAHRIAN-------IRCCSAVTPVTVLVFCGPARLTSNALQEPS 1082

  Fly  1052 APRFDKTSGKIFCHVDATFGKSGWELPLGEVEMPLSEKACCYFGM--------FLLDGEVCSRLA 1108
            :.|.|                   .:|....:..:.::.......        |.|:.|..|.|.
  Rat  1083 SFRAD-------------------GIPNDSSDSEMEDRTTANLAALKLDEWLNFKLEPEAASLLL 1128

  Fly  1109 DFRSKLKS-------TPASVIKSWSSMNNKVLRFKRALITKQ 1143
            ..|.|..|       .|:   |.||.::...:|...|:::.:
  Rat  1129 QLRQKWHSLFLRRMRAPS---KPWSQVDEATIRAIIAVLSTE 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	249/993 (25%)
		DEXDc	279..418	CDD:238005	61/146 (42%)
		P-loop_NTPase	369..>500	CDD:304359	40/201 (20%)
		HELICc	619..704	CDD:197757	33/84 (39%)
		HA2	774..859	CDD:214852	24/93 (26%)
		OB_NTP_bind	915..1039	CDD:285018	30/156 (19%)
Ythdc2	XP_038953178.1	R3H_DEXH_helicase	50..108	CDD:100077	9/57 (16%)
		HrpA	193..>1020	CDD:224557	227/897 (25%)
		DEXHc_YTHDC2	197..372	CDD:350745	72/186 (39%)
		ANK repeat	509..541	CDD:293786	6/31 (19%)
		ANK repeat	543..571	CDD:293786	2/31 (6%)
		OB_NTP_bind	975..1070	CDD:400182	25/114 (22%)
		YTH	1293..1422	CDD:410979
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910