Protein Alignment kz and Ythdc2

DIOPT Version :10

• Sequence 1: NP_476591.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_001414131.1
• Gene: Ythdc2 / 307446
• RGDID: 1563192
• Length: 1434
• Species: Rattus norvegicus
• Alignment Length: 1277
• Identity: 299/1277 - (23%)
• Similarity: 483/1277 - (37%)
• Gaps: 366/1277 - (28%)

  Fly    89 GRAQLLGDL-------AAVQI--------PEEELQQYTSISQVQTVGLKRLPT------------ 126
            |||:.|.|:       .||.|        .:.|::..:|::..:...:.||..
  Rat    35 GRAKGLKDIRIDEEVKIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKG 99

  Fly   127 LDEYLAKKKERQAQVLAEKSSASGLRVNAIKGSKRKLLV------EEEEELQAKRKNPNVISVE- 184
            .:.||..||:..::. |.......|..|. |.:.|.|:.      :|..||..|.:..||.:||
  Rat   100 ANRYLTVKKKDGSET-AHAMMTCNLTHNT-KHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEA 162

  Fly   185 EDDEDSSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHR 249
            |:.|.|.:|...:...|                                          .|||.|
  Rat   163 ENREMSKTSGRLNNGIP------------------------------------------QVPVKR 185

  Fly   250 -TTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQHKMIGV--- 310
             .:|..:.|..||:..:::::::.|.||.:|::.||||||||||:||||.:..:..    |:
  Rat   186 GESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKN----GIPCR 246

  Fly   311 ---TEPRRVAAIAMSKRVAHEMNLPESE-VSYLIRFEGNVTPATRIKFMTDGVLLKEIET-DFLL 370
               |:|||:||||:::|||.|......: :.|.||.|..|:|.|.:.|.|:||||:.:.. |..|
  Rat   247 IFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTL 311

  Fly   371 SKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPPP 435
            |..:.:|:||.|||..::|.   ||:::..|..|. ..||||:.||.|.|:.|   .|.|. ..|
  Rat   312 STVTHVIVDEVHERDRFSDF---LLTKLRDLLQKH-PTLKLILSSAALDVNLF---IRYFG-SCP 368

  Fly   436 LLKVEARQFPVTIHF--------------------------------------QKRT--PDDYVA 460
            ::.::.|.|.|...|                                      |:.|  |:....
  Rat   369 VIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQ 433

  Fly   461 EAYRKTLKIHNKLPEGGILIF-------------------------------VTGQQEVNQLVRK 494
            .|.....:.::.|.:||..:|                               |....:|..|:..
  Rat   434 RAVASVSEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILT 498

  Fly   495 LRRTFPYHHAPTKDVA---KNGKVSEEEKEETIDDAASTVEDPKE--------LEFDMKRVIRNI 548
            ...:..|.|:.|...|   ..|:....:.|:.|...|:.......        ..|....::..:
  Rat   499 ENVSVDYRHSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLL 563

  Fly   549 RKSKKKFLAQMALPKINLDDYKL---PGDDTEADMHE-----QPDEDDEQEGLE----------- 594
                :.:.|.:...  |||:..|   .|:|..|:..|     ....|||:..|:
  Rat   564 ----ESYSASLEFG--NLDESSLVQTNGNDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICH 622

  Fly   595 -----------EDNDDELGLED----ESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRL 644
                       ...|:.:||.|    :....:.......|..|:|.:.:..|.::....|.|.|.
  Rat   623 SCDAGAILIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRK 687

  Fly   645 CVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHC 709
            .::|||:||||:|:..:.:|:|.|:.|.:.:|.|..|:...:.:.|||||.||.|||||...|.|
  Rat   688 IILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGIC 752

  Fly   710 YRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQ------MRCMGIDRVVHFPFPSPPDQVQLQAAE 768
            :||:|...:.:..| |..|::.:.|:::|.|.      :.|...|.::..|.|.|
  Rat   753 FRLFSRLRFQNMLE-FQTPELLRMPLQELCLHTKLLAPVNCTIADFLMKAPEPPP---------- 806

  Fly   769 RRLIVLGALEVAKT-ENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSV 832
             .|||..|:::.|| :..|....:|.||:.::..||.|..|||:            :|.|....:
  Rat   807 -ALIVRNAVQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMV------------LCAVVLKCL 858

  Fly   833 QEVLIE--TGVQRDEDVAP------GANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQ 889
            ..:|..  |...||..|.|      .|....|||   ..:|.:   .|.|.||||..|.:.|.|.
  Rat   859 DPILTIACTLAYRDPFVLPTQASQKRAAMLCRKR---FTAGTF---SDHMALLRAFQAWQKARSD 917

  Fly   890 GRLPEFCAANGLRQKAMSEVRKLRVQLTNEINL----------NVSDVELGVDPELKPPTDAQA- 943
            |....||..|.|.|..|..:..:|.||..::..          ::.||.          |:::.
  Rat   918 GWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVN----------TNSENW 972

  Fly   944 RFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQ----KAP-- 1002
            ..::..|:|||...:..       .|:|.      .......|:....|.:|||.|    |.|
  Rat   973 AVVKAALVAGMYPNLVH-------VDREN------VVLTGPKEKKVRFHPTSVLSQPQYKKIPPA 1024

  Fly  1003 ------------EWVIYQE---AYELQNGDSTKMFIRGITAIEPEWLLLYV-PLLCNIREVREDP 1051
                        :|:||.|   |:.:.|       ||..:|:.|..:|::. |.......::|..
  Rat  1025 NGQAAAIQALPTDWLIYDEMTRAHRIAN-------IRCCSAVTPVTVLVFCGPARLTSNALQEPS 1082

  Fly  1052 APRFDKTSGKIFCHVDATFGKSGWELPLGEVEMPLSEKACCYFGM--------FLLDGEVCSRLA 1108
            :.|.|                   .:|....:..:.::.......        |.|:.|..|.|.
  Rat  1083 SFRAD-------------------GIPNDSSDSEMEDRTTANLAALKLDEWLNFKLEPEAASLLL 1128

  Fly  1109 DFRSKLKS-------TPASVIKSWSSMNNKVLRFKRALITKQ 1143
            ..|.|..|       .|:   |.||.::...:|...|:::.:
  Rat  1129 QLRQKWHSLFLRRMRAPS---KPWSQVDEATIRAIIAVLSTE 1167

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_476591.1	HrpA	260..>1071	CDD:441249	243/982 (25%)
		DEXHc_DHX37	260..439	CDD:350740	72/186 (39%)
Ythdc2	NP_001414131.1	None