Protein Alignment kz and Tdrd9

DIOPT Version :10

• Sequence 1: NP_476591.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: XP_017450003.1
• Gene: Tdrd9 / 299343
• RGDID: 1306942
• Length: 1396
• Species: Rattus norvegicus
• Alignment Length: 876
• Identity: 226/876 - (25%)
• Similarity: 374/876 - (42%)
• Gaps: 213/876 - (24%)

  Fly   161 RKLLVEEEEELQAKRKN---------PNVISVEEDDEDSSSSDEDDEEAPAQSA--PI---AIPT 211
            |||.|::..:.....|.         |.....|...|:...|:|...|||...|  |:   |:..
  Rat     3 RKLTVDQINDWFTIGKTVTNVELLGLPPAFPAEAPREEVQRSEEVPSEAPTAQAQDPVKATALAR 67

  Fly   212 PVSI--------------------------------APPQ-IAVKPPIKKLKPEPNPPACIHQTV 243
            |.|.                                .||. ..::.|:.|:    :..|||.:|.
  Rat    68 PASAFGRSLSQRSSEVEYINKYRQLEAQELDIYGQDQPPSGPGLRSPLAKI----SNVACIPETT 128

  Fly   244 Y----VPVHRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQ 304
            |    :|::|..|               :|:..|..|.:||:.|.|||||:|||||::.: .|.|
  Rat   129 YKYPDLPINRCKE---------------EVISLIESNSVVIIHGATGSGKSTQLPQYVLD-HYTQ 177

  Fly   305 HKM---IGVTEPRRVAAIAMSKRVAHEMNLP-ESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIE 365
            ...   |.||:||::.|.::::.::.|.:.. ...|.|.:..|...|..||:.:||.||||::|.
  Rat   178 RSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLVGYQVGLEKTATEDTRLIYMTTGVLLQKIV 242

  Fly   366 TDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLF 430
            :...|.:::.:.:||.|||:...|.|:.::.:::   ....:.:|:|:||||:....|.:   .|
  Rat   243 SAKSLMEFTHVFIDEVHERTEEMDFLLLVVRKLL---RTNSRFVKVILMSATINCKQFAD---YF 301

  Fly   431 KIPPPLLKVEARQFPVTIHFQKRTPDDYVAEAYRKTLK--IHNKLPEGGILIFVTGQQEVNQLVR 493
            .:|     |:.:..|..: |:.......:.:.|...|.  .|:.||
  Rat   302 AVP-----VQNKMNPAYV-FEVEGKPHTIEQYYLNDLGHIYHSGLP------------------- 341

  Fly   494 KLRRTFPYH-HAP--TKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKF 555
                  ||. ..|  ||||              .:.|.|.::...:|  |||. ..|...|..:|
  Rat   342 ------PYRLEEPVITKDV--------------YEVAVSLIQMFDDL--DMKE-SGNKTWSGAQF 383

  Fly   556 LAQMA-----LPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQ 615
            :::.:     ||.:...:|          |||.                         :.:...:
  Rat   384 VSERSSVLVFLPGLGEINY----------MHEL-------------------------LTNMIHK 413

  Fly   616 PLWVLPLYSLLSSEKQNRIFL-PVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLT 679
            .|.|.||:|.::.|:||.:|| ||| |.|..::|||:||:|:|:|.:|||:|....:|.:.|:.|
  Rat   414 RLQVYPLHSSVTLEEQNNVFLSPVP-GYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDT 477

  Fly   680 GVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRC 744
            ...:..:::.||.|.|||.|||||:|.|:||||.....::....|...|::.:.|:...:|:::.
  Rat   478 NYQSLRLSWASKTSCDQRKGRAGRVSKGYCYRLIHRDFWDSAIPDHVVPEMLRCPLGSTVLKVKL 542

  Fly   745 --MGIDRVVHFPFPSPPDQVQLQAAERRLIVL---GALEVAKTENTDLP--PAVTRLGHVISRFP 802
              ||..|.:.....|||   .|...||.:::|   |||.|:.....:.|  ..:|.||.|:::.|
  Rat   543 LDMGEPRALLATALSPP---SLSDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLP 604

  Fly   803 VAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRDEDVAPGANRFHRKRQSWAASGNY 867
            |:.:.||::.|.|....|...:.:.||||::...          ..|........|.....||:.
  Rat   605 VSQQLGKLIVLGHVFGCLDECLIIAAALSLKNFF----------TMPFRQHLDGYRNKVHFSGSS 659

  Fly   868 QLLGDPMVLLRAVGAAEYAGSQGRLP------EFCAANGLRQKAMSEVRKLRVQLTNEINLNVSD 926
            :  .|.:.|:.|..|.:....:|.|.      ::...|.::.|.:.||.:|..:|.|.|    |.
  Rat   660 R--SDCLALVEAFRAWQACRQRGELRHPKDELDWGRLNYIQIKRIREVAELYEELKNRI----SQ 718

  Fly   927 VELGVDPELKPPTDAQ----ARFLRQILLAG 953
            ..:.|||. .|..|.:    .||:.|::|||
  Rat   719 FNMFVDPR-HPVLDQEYPYKQRFILQVVLAG 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_476591.1	HrpA	260..>1071	CDD:441249	196/726 (27%)
		DEXHc_DHX37	260..439	CDD:350740	55/182 (30%)
Tdrd9	XP_017450003.1	HrpA	132..>707	CDD:441249	183/695 (26%)
		DEAD-like_helicase_N	134..317	CDD:475120	61/210 (29%)
		Tudor_TDRD9	919..1018	CDD:410502