DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and Dhx16

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_997661.1	Gene:	Dhx16 / 294232	RGDID:	1302963	Length:	1044	Species:	Rattus norvegicus

Alignment Length:	1073	Identity:	288/1073 - (26%)
Similarity:	462/1073 - (43%)	Gaps:	293/1073 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 YDEANALVLPSEKRATKIKVDKVQHVKILSKKQRKHLQAIVDKKKKKEGRAQ------LLGDLAA 99
            |:||       :||....:.|:...|..|.||.|:...|..:::|.::..|:      |.||:..
  Rat   207 YEEA-------QKRLKMAEEDRKAMVPELRKKSRREYLAKREREKLEDLEAELADEEVLFGDVEL 264

  Fly   100 VQIPEEEL----------QQYTSISQVQTVGLKRLPTLDEYLAKKK-----ERQAQVLAEKSSAS 149
            .:....||          ::|.:..:.:     :|...:.|...|:     .|...::.|:|.|.
  Rat   265 SRHERRELKYKRRVRDLAREYRAAGEQE-----KLEATNRYHMPKETRGQPARATDIVEEESGAP 324

  Fly   150 G----------LRVNAIKGSKR---------KLLVEEEEELQAKRKNPNVISVEEDDEDSSSSDE 195
            |          |...::|...|         :|::||:|.::..|    ...::.|:|.||.
  Rat   325 GEEQRRWEEARLDAASLKFGARDAAAQEPQYQLVLEEDETIEFVR----AAQLQGDEEPSSG--- 382

  Fly   196 DDEEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRTTEVQNARLRL 260
                                        ||:.                 ....:...:|..|..|
  Rat   383 ----------------------------PPLS-----------------AQAQQKESIQAVRRSL 402

  Fly   261 PILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQHKM-IGVTEPRRVAAIAMSKR 324
            |:....::::..|..:.::|:.||||||||||:||:|:|.||.:..| |..|:||||||::::.|
  Rat   403 PVFPFREELLTAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTKKGMKIACTQPRRVAAMSVAAR 467

  Fly   325 VAHEMNLP-ESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYT 388
            ||.||.:. .:||.|.||||...:..|.:::||||:||:|..::..|:.|||:::||||||:::|
  Rat   468 VAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHT 532

  Fly   389 DILVGLLSRIVPLRHKRGQPLKLIIMSATL---RVSDFTENTRLFKIPPPLLKVEARQFPVTIHF 450
            |||.||:..:...|.:    ||:::.||||   |.|.|.::..:|:||       .|:|||.|.:
  Rat   533 DILFGLIKDVARFRPE----LKVLVASATLDTARFSAFFDDAPVFRIP-------GRRFPVDIFY 586

  Fly   451 QKRTPDDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKV 515
            .|....||:.......|:||...|.|.||:|:|||:|
  Rat   587 TKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEE---------------------------- 623

  Fly   516 SEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADM 580
                    |:.|...::|             ..|:
  Rat   624 --------IEAACEMLQD-------------RCRR------------------------------ 637

  Fly   581 HEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLC 645
                                        :||..|: |.|||:|:.|.|:.|.|||.|.|.|.|..
  Rat   638 ----------------------------LGSKIRE-LLVLPIYANLPSDMQARIFQPTPPGARKV 673

  Fly   646 VVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCY 710
            ||:||:|||||||..|.||:|.|..|.:.|:..||:.:..||..|||||:||||||||::||.|:
  Rat   674 VVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCF 738

  Fly   711 RLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLG 775
            |||::..|....|:.:.|:||:..:.:::|.::.:||..::||.|..||....|..|..:|..||
  Rat   739 RLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALG 803

  Fly   776 ALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETG 840
            ||...        ..:|..|..::..||.|...||:..|.:.:.....:.:.|.|||...:
  Rat   804 ALNHL--------GELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSI---- 856

  Fly   841 VQRDEDVAPGANRFHRKRQSWAASGNYQLL-----GDPMVLLRAVGAAEYAGSQGRLPEFCAANG 900
                         |:|.:.....:.|.::.     ||.:|||...  .::|.| |...::|..|.
  Rat   857 -------------FYRPKDKVVHADNARVNFFLPGGDHLVLLNVY--TQWAES-GYSSQWCYENF 905

  Fly   901 LRQKAMSEVRKLRVQLTNEINLNVSDVELGVDPELKPPTDAQARF--LRQILLAGMGDRVARKVP 963
            ::.::|...|.:|.||...:    ..||:|:       |..|..:  :|:.:.:|.....||..
  Rat   906 VQFRSMRRARDVREQLEGLL----ERVEVGL-------TSCQGDYVRVRKAITSGYFYHTARLT- 958

  Fly   964 LADIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITA 1028
                         :..|.....::..|:|.:|.|.::.|.|::|.|...     :||.|:|.:..
  Rat   959 -------------RSGYRTVKQQQTVFIHPNSSLFEQQPRWLLYHELVL-----TTKEFMRQVLE 1005

  Fly  1029 IEPEWLLLYVPLLCNIREVREDPAPRFDKTSGK 1061
            ||..|||...|.....:|:.:..|.:..|..||
  Rat  1006 IESSWLLEVAPHYYKAKELEDPHAKKMPKKVGK 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	243/832 (29%)
		DEXDc	279..418	CDD:238005	67/140 (48%)
		P-loop_NTPase	369..>500	CDD:304359	49/133 (37%)
		HELICc	619..704	CDD:197757	48/84 (57%)
		HA2	774..859	CDD:214852	18/84 (21%)
		OB_NTP_bind	915..1039	CDD:285018	29/125 (23%)
Dhx16	NP_997661.1	DEXDc	402..584	CDD:214692	82/192 (43%)
		DEXDc	419..558	CDD:238005	67/142 (47%)
		HELICc	583..740	CDD:238034	76/264 (29%)
		HA2	801..885	CDD:214852	22/108 (20%)
		OB_NTP_bind	920..1018	CDD:285018	30/127 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820